Association of Gray Matter and Personality Development With Increased Drunkenness Frequency During Adolescence
Standard
Association of Gray Matter and Personality Development With Increased Drunkenness Frequency During Adolescence. / Robert, Gabriel H; Luo, Qiang; Yu, Tao; Chu, Congying; Ing, Alex; Jia, Tianye; Papadopoulos Orfanos, Dimitri; Burke-Quinlan, Erin; Desrivières, Sylvane; Ruggeri, Barbara; Spechler, Philip; Chaarani, Bader; Tay, Nicole; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Flor, Herta; Frouin, Vincent; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Nees, Frauke; Poustka, Luise; Smolka, Michael N; Vetter, Nora C; Walter, Henrik; Whelan, Robert; Conrod, Patricia; Barker, Ted; Garavan, Hugh; Schumann, Gunter; IMAGEN Consortium.
In: JAMA PSYCHIAT, Vol. 77, No. 4, 01.04.2020, p. 409-419.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Association of Gray Matter and Personality Development With Increased Drunkenness Frequency During Adolescence
AU - Robert, Gabriel H
AU - Luo, Qiang
AU - Yu, Tao
AU - Chu, Congying
AU - Ing, Alex
AU - Jia, Tianye
AU - Papadopoulos Orfanos, Dimitri
AU - Burke-Quinlan, Erin
AU - Desrivières, Sylvane
AU - Ruggeri, Barbara
AU - Spechler, Philip
AU - Chaarani, Bader
AU - Tay, Nicole
AU - Banaschewski, Tobias
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Flor, Herta
AU - Frouin, Vincent
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Martinot, Jean-Luc
AU - Paillère Martinot, Marie-Laure
AU - Nees, Frauke
AU - Poustka, Luise
AU - Smolka, Michael N
AU - Vetter, Nora C
AU - Walter, Henrik
AU - Whelan, Robert
AU - Conrod, Patricia
AU - Barker, Ted
AU - Garavan, Hugh
AU - Schumann, Gunter
AU - IMAGEN Consortium
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Importance: Alcohol abuse correlates with gray matter development in adolescents, but the directionality of this association remains unknown.Objective: To investigate the directionality of the association between gray matter development and increase in frequency of drunkenness among adolescents.Design, Setting, and Participants: This cohort study analyzed participants of IMAGEN, a multicenter brain imaging study of healthy adolescents in 8 European sites in Germany (Mannheim, Dresden, Berlin, and Hamburg), the United Kingdom (London and Nottingham), Ireland (Dublin), and France (Paris). Data from the second follow-up used in the present study were acquired from January 1, 2013, to December 31, 2016, and these data were analyzed from January 1, 2016, to March 31, 2018. Analyses were controlled for sex, site, socioeconomic status, family history of alcohol dependency, puberty score, negative life events, personality, cognition, and polygenic risk scores. Personality and frequency of drunkenness were assessed at age 14 years (baseline), 16 years (first follow-up), and 19 years (second follow-up). Structural brain imaging scans were acquired at baseline and second follow-up time points.Main Outcomes and Measures: Increases in drunkenness frequency were measured by latent growth modeling, a voxelwise hierarchical linear model was used to observe gray matter volume, and tensor-based morphometry was used for gray matter development. The hypotheses were formulated before the data analyses.Results: A total of 726 adolescents (mean [SD] age at baseline, 14.4 [0.38] years; 418 [58%] female) were included. The increase in drunkenness frequency was associated with accelerated gray matter atrophy in the left posterior temporal cortex (peak: t1,710 = -5.8; familywise error (FWE)-corrected P = 7.2 × 10-5; cluster: 6297 voxels; P = 2.7 × 10-5), right posterior temporal cortex (cluster: 2070 voxels; FWE-corrected P = .01), and left prefrontal cortex (peak: t1,710 = -5.2; FWE-corrected P = 2 × 10-3; cluster: 10 624 voxels; P = 1.9 × 10-7). According to causal bayesian network analyses, 73% of the networks showed directionality from gray matter development to drunkenness increase as confirmed by accelerated gray matter atrophy in late bingers compared with sober controls (n = 20 vs 60; β = 1.25; 95% CI, -2.15 to -0.46; t1,70 = 0.3; P = .004), the association of drunkenness increase with gray matter volume at age 14 years (β = 0.23; 95% CI, 0.01-0.46; t1,584 = 2; P = .04), the association between gray matter atrophy and alcohol drinking units (β = -0.0033; 95% CI, -6 × 10-3 to -5 × 10-4; t1,509 = -2.4; P = .02) and drunkenness frequency at age 23 years (β = -0.16; 95% CI, -0.28 to -0.03; t1,533 = -2.5; P = .01), and the linear exposure-response curve stratified by gray matter atrophy and not by increase in frequency of drunkenness.Conclusions and Relevance: This study found that gray matter development and impulsivity were associated with increased frequency of drunkenness by sex. These results suggest that neurotoxicity-related gray matter atrophy should be interpreted with caution.
AB - Importance: Alcohol abuse correlates with gray matter development in adolescents, but the directionality of this association remains unknown.Objective: To investigate the directionality of the association between gray matter development and increase in frequency of drunkenness among adolescents.Design, Setting, and Participants: This cohort study analyzed participants of IMAGEN, a multicenter brain imaging study of healthy adolescents in 8 European sites in Germany (Mannheim, Dresden, Berlin, and Hamburg), the United Kingdom (London and Nottingham), Ireland (Dublin), and France (Paris). Data from the second follow-up used in the present study were acquired from January 1, 2013, to December 31, 2016, and these data were analyzed from January 1, 2016, to March 31, 2018. Analyses were controlled for sex, site, socioeconomic status, family history of alcohol dependency, puberty score, negative life events, personality, cognition, and polygenic risk scores. Personality and frequency of drunkenness were assessed at age 14 years (baseline), 16 years (first follow-up), and 19 years (second follow-up). Structural brain imaging scans were acquired at baseline and second follow-up time points.Main Outcomes and Measures: Increases in drunkenness frequency were measured by latent growth modeling, a voxelwise hierarchical linear model was used to observe gray matter volume, and tensor-based morphometry was used for gray matter development. The hypotheses were formulated before the data analyses.Results: A total of 726 adolescents (mean [SD] age at baseline, 14.4 [0.38] years; 418 [58%] female) were included. The increase in drunkenness frequency was associated with accelerated gray matter atrophy in the left posterior temporal cortex (peak: t1,710 = -5.8; familywise error (FWE)-corrected P = 7.2 × 10-5; cluster: 6297 voxels; P = 2.7 × 10-5), right posterior temporal cortex (cluster: 2070 voxels; FWE-corrected P = .01), and left prefrontal cortex (peak: t1,710 = -5.2; FWE-corrected P = 2 × 10-3; cluster: 10 624 voxels; P = 1.9 × 10-7). According to causal bayesian network analyses, 73% of the networks showed directionality from gray matter development to drunkenness increase as confirmed by accelerated gray matter atrophy in late bingers compared with sober controls (n = 20 vs 60; β = 1.25; 95% CI, -2.15 to -0.46; t1,70 = 0.3; P = .004), the association of drunkenness increase with gray matter volume at age 14 years (β = 0.23; 95% CI, 0.01-0.46; t1,584 = 2; P = .04), the association between gray matter atrophy and alcohol drinking units (β = -0.0033; 95% CI, -6 × 10-3 to -5 × 10-4; t1,509 = -2.4; P = .02) and drunkenness frequency at age 23 years (β = -0.16; 95% CI, -0.28 to -0.03; t1,533 = -2.5; P = .01), and the linear exposure-response curve stratified by gray matter atrophy and not by increase in frequency of drunkenness.Conclusions and Relevance: This study found that gray matter development and impulsivity were associated with increased frequency of drunkenness by sex. These results suggest that neurotoxicity-related gray matter atrophy should be interpreted with caution.
KW - Adolescent
KW - Adolescent Development
KW - Alcoholic Intoxication/epidemiology
KW - Female
KW - Frontal Lobe/growth & development
KW - Gray Matter/growth & development
KW - Humans
KW - Impulsive Behavior
KW - Male
KW - Personality Development
KW - Risk Factors
KW - Sex Factors
KW - Temporal Lobe/growth & development
KW - Young Adult
U2 - 10.1001/jamapsychiatry.2019.4063
DO - 10.1001/jamapsychiatry.2019.4063
M3 - SCORING: Journal article
C2 - 31851304
VL - 77
SP - 409
EP - 419
JO - JAMA PSYCHIAT
JF - JAMA PSYCHIAT
SN - 2168-622X
IS - 4
ER -