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Association of ESR1 gene tagging SNPs with breast cancer risk.

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Association of ESR1 gene tagging SNPs with breast cancer risk. / Dunning, Alison M; Healey, Catherine S; Baynes, Caroline; Maia, Ana-Teresa; Scollen, Serena; Vega, Ana; Rodríguez, Raquel; Barbosa-Morais, Nuno L; Ponder, Bruce A J; Low, Yen-Ling; Bingham, Sheila; Haiman, Christopher A; Loic, Le Marchand; Broeks, Annegien; Schmidt, Marjanka K; Hopper, John; Southey, Melissa; Beckmann, Matthias W; Fasching, Peter A; Peto, Julian; Johnson, Nichola; Bojesen, Stig E; Nordestgaard, Børge; Milne, Roger L; Benitez, Javier; Hamann, Ute; Ko, Yon; Schmutzler, Rita K; Burwinkel, Barbara; Schürmann, Peter; Dörk, Thilo; Heikkinen, Tuomas; Nevanlinna, Heli; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kosma, Veli-Matti; Chen, Xiaoqing; Spurdle, Amanda; Jenny, Change-Claude; Flesch-Janys, Dieter; Couch, Fergus J; Olson, Janet E; Severi, Gianluca; Baglietto, Laura; Børresen-Dale, Anne-Lise; Kristensen, Vessela; Hunter, David J; Hankinson, Susan E; Devilee, Peter; Vreeswijk, Maaike; Lissowska, Jolanta; Brinton, Louise; Liu, Jianjun; Hall, Per; Kang, Daehee; Yoo, Keun-Young; Shen, Chen-Yang; Yu, Jyh-Cherng; Anton-Culver, Hoda; Ziogoas, Argyrios; Sigurdson, Alice; Struewing, Jeff; Easton, Douglas F; Garcia-Closas, Montserrat; Humphreys, Manjeet K; Morrison, Jonathan; Pharoah, Paul D P; Pooley, Karen A; Chenevix-Trench, Georgia.

In: HUM MOL GENET, Vol. 18, No. 6, 6, 2009, p. 1131-1139.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dunning, AM, Healey, CS, Baynes, C, Maia, A-T, Scollen, S, Vega, A, Rodríguez, R, Barbosa-Morais, NL, Ponder, BAJ, Low, Y-L, Bingham, S, Haiman, CA, Loic, LM, Broeks, A, Schmidt, MK, Hopper, J, Southey, M, Beckmann, MW, Fasching, PA, Peto, J, Johnson, N, Bojesen, SE, Nordestgaard, B, Milne, RL, Benitez, J, Hamann, U, Ko, Y, Schmutzler, RK, Burwinkel, B, Schürmann, P, Dörk, T, Heikkinen, T, Nevanlinna, H, Lindblom, A, Margolin, S, Mannermaa, A, Kosma, V-M, Chen, X, Spurdle, A, Jenny, C-C, Flesch-Janys, D, Couch, FJ, Olson, JE, Severi, G, Baglietto, L, Børresen-Dale, A-L, Kristensen, V, Hunter, DJ, Hankinson, SE, Devilee, P, Vreeswijk, M, Lissowska, J, Brinton, L, Liu, J, Hall, P, Kang, D, Yoo, K-Y, Shen, C-Y, Yu, J-C, Anton-Culver, H, Ziogoas, A, Sigurdson, A, Struewing, J, Easton, DF, Garcia-Closas, M, Humphreys, MK, Morrison, J, Pharoah, PDP, Pooley, KA & Chenevix-Trench, G 2009, 'Association of ESR1 gene tagging SNPs with breast cancer risk.', HUM MOL GENET, vol. 18, no. 6, 6, pp. 1131-1139. <http://www.ncbi.nlm.nih.gov/pubmed/19126777?dopt=Citation>

APA

Dunning, A. M., Healey, C. S., Baynes, C., Maia, A-T., Scollen, S., Vega, A., Rodríguez, R., Barbosa-Morais, N. L., Ponder, B. A. J., Low, Y-L., Bingham, S., Haiman, C. A., Loic, L. M., Broeks, A., Schmidt, M. K., Hopper, J., Southey, M., Beckmann, M. W., Fasching, P. A., ... Chenevix-Trench, G. (2009). Association of ESR1 gene tagging SNPs with breast cancer risk. HUM MOL GENET, 18(6), 1131-1139. [6]. http://www.ncbi.nlm.nih.gov/pubmed/19126777?dopt=Citation

Vancouver

Dunning AM, Healey CS, Baynes C, Maia A-T, Scollen S, Vega A et al. Association of ESR1 gene tagging SNPs with breast cancer risk. HUM MOL GENET. 2009;18(6):1131-1139. 6.

Bibtex

@article{512acf808cb24bfbb3a89238fd98d1bd,
title = "Association of ESR1 gene tagging SNPs with breast cancer risk.",
abstract = "We have conducted a three-stage, comprehensive single nucleotide polymorphism (SNP)-tagging association study of ESR1 gene variants (SNPs) in more than 55,000 breast cancer cases and controls from studies within the Breast Cancer Association Consortium (BCAC). No large risks or highly significant associations were revealed. SNP rs3020314, tagging a region of ESR1 intron 4, is associated with an increase in breast cancer susceptibility with a dominant mode of action in European populations. Carriers of the c-allele have an odds ratio (OR) of 1.05 [95% Confidence Intervals (CI) 1.02-1.09] relative to t-allele homozygotes, P = 0.004. There is significant heterogeneity between studies, P = 0.002. The increased risk appears largely confined to oestrogen receptor-positive tumour risk. The region tagged by SNP rs3020314 contains sequence that is more highly conserved across mammalian species than the rest of intron 4, and it may subtly alter the ratio of two mRNA splice forms.",
author = "Dunning, {Alison M} and Healey, {Catherine S} and Caroline Baynes and Ana-Teresa Maia and Serena Scollen and Ana Vega and Raquel Rodr{\'i}guez and Barbosa-Morais, {Nuno L} and Ponder, {Bruce A J} and Yen-Ling Low and Sheila Bingham and Haiman, {Christopher A} and Loic, {Le Marchand} and Annegien Broeks and Schmidt, {Marjanka K} and John Hopper and Melissa Southey and Beckmann, {Matthias W} and Fasching, {Peter A} and Julian Peto and Nichola Johnson and Bojesen, {Stig E} and B{\o}rge Nordestgaard and Milne, {Roger L} and Javier Benitez and Ute Hamann and Yon Ko and Schmutzler, {Rita K} and Barbara Burwinkel and Peter Sch{\"u}rmann and Thilo D{\"o}rk and Tuomas Heikkinen and Heli Nevanlinna and Annika Lindblom and Sara Margolin and Arto Mannermaa and Veli-Matti Kosma and Xiaoqing Chen and Amanda Spurdle and Change-Claude Jenny and Dieter Flesch-Janys and Couch, {Fergus J} and Olson, {Janet E} and Gianluca Severi and Laura Baglietto and Anne-Lise B{\o}rresen-Dale and Vessela Kristensen and Hunter, {David J} and Hankinson, {Susan E} and Peter Devilee and Maaike Vreeswijk and Jolanta Lissowska and Louise Brinton and Jianjun Liu and Per Hall and Daehee Kang and Keun-Young Yoo and Chen-Yang Shen and Jyh-Cherng Yu and Hoda Anton-Culver and Argyrios Ziogoas and Alice Sigurdson and Jeff Struewing and Easton, {Douglas F} and Montserrat Garcia-Closas and Humphreys, {Manjeet K} and Jonathan Morrison and Pharoah, {Paul D P} and Pooley, {Karen A} and Georgia Chenevix-Trench",
year = "2009",
language = "Deutsch",
volume = "18",
pages = "1131--1139",
journal = "HUM MOL GENET",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Association of ESR1 gene tagging SNPs with breast cancer risk.

AU - Dunning, Alison M

AU - Healey, Catherine S

AU - Baynes, Caroline

AU - Maia, Ana-Teresa

AU - Scollen, Serena

AU - Vega, Ana

AU - Rodríguez, Raquel

AU - Barbosa-Morais, Nuno L

AU - Ponder, Bruce A J

AU - Low, Yen-Ling

AU - Bingham, Sheila

AU - Haiman, Christopher A

AU - Loic, Le Marchand

AU - Broeks, Annegien

AU - Schmidt, Marjanka K

AU - Hopper, John

AU - Southey, Melissa

AU - Beckmann, Matthias W

AU - Fasching, Peter A

AU - Peto, Julian

AU - Johnson, Nichola

AU - Bojesen, Stig E

AU - Nordestgaard, Børge

AU - Milne, Roger L

AU - Benitez, Javier

AU - Hamann, Ute

AU - Ko, Yon

AU - Schmutzler, Rita K

AU - Burwinkel, Barbara

AU - Schürmann, Peter

AU - Dörk, Thilo

AU - Heikkinen, Tuomas

AU - Nevanlinna, Heli

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Mannermaa, Arto

AU - Kosma, Veli-Matti

AU - Chen, Xiaoqing

AU - Spurdle, Amanda

AU - Jenny, Change-Claude

AU - Flesch-Janys, Dieter

AU - Couch, Fergus J

AU - Olson, Janet E

AU - Severi, Gianluca

AU - Baglietto, Laura

AU - Børresen-Dale, Anne-Lise

AU - Kristensen, Vessela

AU - Hunter, David J

AU - Hankinson, Susan E

AU - Devilee, Peter

AU - Vreeswijk, Maaike

AU - Lissowska, Jolanta

AU - Brinton, Louise

AU - Liu, Jianjun

AU - Hall, Per

AU - Kang, Daehee

AU - Yoo, Keun-Young

AU - Shen, Chen-Yang

AU - Yu, Jyh-Cherng

AU - Anton-Culver, Hoda

AU - Ziogoas, Argyrios

AU - Sigurdson, Alice

AU - Struewing, Jeff

AU - Easton, Douglas F

AU - Garcia-Closas, Montserrat

AU - Humphreys, Manjeet K

AU - Morrison, Jonathan

AU - Pharoah, Paul D P

AU - Pooley, Karen A

AU - Chenevix-Trench, Georgia

PY - 2009

Y1 - 2009

N2 - We have conducted a three-stage, comprehensive single nucleotide polymorphism (SNP)-tagging association study of ESR1 gene variants (SNPs) in more than 55,000 breast cancer cases and controls from studies within the Breast Cancer Association Consortium (BCAC). No large risks or highly significant associations were revealed. SNP rs3020314, tagging a region of ESR1 intron 4, is associated with an increase in breast cancer susceptibility with a dominant mode of action in European populations. Carriers of the c-allele have an odds ratio (OR) of 1.05 [95% Confidence Intervals (CI) 1.02-1.09] relative to t-allele homozygotes, P = 0.004. There is significant heterogeneity between studies, P = 0.002. The increased risk appears largely confined to oestrogen receptor-positive tumour risk. The region tagged by SNP rs3020314 contains sequence that is more highly conserved across mammalian species than the rest of intron 4, and it may subtly alter the ratio of two mRNA splice forms.

AB - We have conducted a three-stage, comprehensive single nucleotide polymorphism (SNP)-tagging association study of ESR1 gene variants (SNPs) in more than 55,000 breast cancer cases and controls from studies within the Breast Cancer Association Consortium (BCAC). No large risks or highly significant associations were revealed. SNP rs3020314, tagging a region of ESR1 intron 4, is associated with an increase in breast cancer susceptibility with a dominant mode of action in European populations. Carriers of the c-allele have an odds ratio (OR) of 1.05 [95% Confidence Intervals (CI) 1.02-1.09] relative to t-allele homozygotes, P = 0.004. There is significant heterogeneity between studies, P = 0.002. The increased risk appears largely confined to oestrogen receptor-positive tumour risk. The region tagged by SNP rs3020314 contains sequence that is more highly conserved across mammalian species than the rest of intron 4, and it may subtly alter the ratio of two mRNA splice forms.

M3 - SCORING: Zeitschriftenaufsatz

VL - 18

SP - 1131

EP - 1139

JO - HUM MOL GENET

JF - HUM MOL GENET

SN - 0964-6906

IS - 6

M1 - 6

ER -