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Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls

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Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls. / Senner, Fanny; Schneider-Axmann, Thomas; Kaurani, Lalit; Zimmermann, Jörg; Wiltfang, Jens; von Hagen, Martin; Vogl, Thomas; Spitzer, Carsten; Senner, Simon; Schulte, Eva C; Schmauß, Max; Schaupp, Sabrina K; Reimer, Jens; Reich-Erkelenz, Daniela; Papiol, Sergi; Kohshour, Mojtaba Oraki; Lang, Fabian U; Konrad, Carsten; Kirchner, Sophie-Kathrin; Kalman, Janos L; Juckel, Georg; Heilbronner, Maria; Heilbronner, Urs; Figge, Christian; Eyl, Ruth E; Dietrich, Detlef; Budde, Monika; Angelescu, Ion-George; Adorjan, Kristina; Schmitt, Andrea; Fischer, Andre; Falkai, Peter; Schulze, Thomas G.

In: SCHIZOPHR RES-COGN, Vol. 32, 06.2023, p. 100280.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Senner, F, Schneider-Axmann, T, Kaurani, L, Zimmermann, J, Wiltfang, J, von Hagen, M, Vogl, T, Spitzer, C, Senner, S, Schulte, EC, Schmauß, M, Schaupp, SK, Reimer, J, Reich-Erkelenz, D, Papiol, S, Kohshour, MO, Lang, FU, Konrad, C, Kirchner, S-K, Kalman, JL, Juckel, G, Heilbronner, M, Heilbronner, U, Figge, C, Eyl, RE, Dietrich, D, Budde, M, Angelescu, I-G, Adorjan, K, Schmitt, A, Fischer, A, Falkai, P & Schulze, TG 2023, 'Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls', SCHIZOPHR RES-COGN, vol. 32, pp. 100280. https://doi.org/10.1016/j.scog.2023.100280

APA

Senner, F., Schneider-Axmann, T., Kaurani, L., Zimmermann, J., Wiltfang, J., von Hagen, M., Vogl, T., Spitzer, C., Senner, S., Schulte, E. C., Schmauß, M., Schaupp, S. K., Reimer, J., Reich-Erkelenz, D., Papiol, S., Kohshour, M. O., Lang, F. U., Konrad, C., Kirchner, S-K., ... Schulze, T. G. (2023). Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls. SCHIZOPHR RES-COGN, 32, 100280. https://doi.org/10.1016/j.scog.2023.100280

Vancouver

Senner F, Schneider-Axmann T, Kaurani L, Zimmermann J, Wiltfang J, von Hagen M et al. Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls. SCHIZOPHR RES-COGN. 2023 Jun;32:100280. https://doi.org/10.1016/j.scog.2023.100280

Bibtex

@article{cbf3b50432314e1893970eb085287ce9,
title = "Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls",
abstract = "As core symptoms of schizophrenia, cognitive deficits contribute substantially to poor outcomes. Early life stress (ELS) can negatively affect cognition in patients with schizophrenia and healthy controls, but the exact nature of the mediating factors is unclear. Therefore, we investigated how ELS, education, and symptom burden are related to cognitive performance. The sample comprised 215 patients with schizophrenia (age, 42.9 ± 12.0 years; 66.0 % male) and 197 healthy controls (age, 38.5 ± 16.4 years; 39.3 % male) from the PsyCourse Study. ELS was assessed with the Childhood Trauma Screener (CTS). We used analyses of covariance and correlation analyses to investigate the association of total ELS load and ELS subtypes with cognitive performance. ELS was reported by 52.1 % of patients and 24.9 % of controls. Independent of ELS, cognitive performance on neuropsychological tests was lower in patients than controls (p < 0.001). ELS load was more closely associated with neurocognitive deficits (cognitive composite score) in controls (r = -0.305, p < 0.001) than in patients (r = -0.163, p = 0.033). Moreover, the higher the ELS load, the more cognitive deficits were found in controls (r = -0.200, p = 0.006), while in patients, this correlation was not significant after adjusting for PANSS. ELS load was more strongly associated with cognitive deficits in healthy controls than in patients. In patients, disease-related positive and negative symptoms may mask the effects of ELS-related cognitive deficits. ELS subtypes were associated with impairments in various cognitive domains. Cognitive deficits appear to be mediated through higher symptom burden and lower educational level.",
author = "Fanny Senner and Thomas Schneider-Axmann and Lalit Kaurani and J{\"o}rg Zimmermann and Jens Wiltfang and {von Hagen}, Martin and Thomas Vogl and Carsten Spitzer and Simon Senner and Schulte, {Eva C} and Max Schmau{\ss} and Schaupp, {Sabrina K} and Jens Reimer and Daniela Reich-Erkelenz and Sergi Papiol and Kohshour, {Mojtaba Oraki} and Lang, {Fabian U} and Carsten Konrad and Sophie-Kathrin Kirchner and Kalman, {Janos L} and Georg Juckel and Maria Heilbronner and Urs Heilbronner and Christian Figge and Eyl, {Ruth E} and Detlef Dietrich and Monika Budde and Ion-George Angelescu and Kristina Adorjan and Andrea Schmitt and Andre Fischer and Peter Falkai and Schulze, {Thomas G}",
note = "{\textcopyright} 2023 The Authors. Published by Elsevier Inc.",
year = "2023",
month = jun,
doi = "10.1016/j.scog.2023.100280",
language = "English",
volume = "32",
pages = "100280",
journal = "SCHIZOPHR RES-COGN",
issn = "2215-0013",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls

AU - Senner, Fanny

AU - Schneider-Axmann, Thomas

AU - Kaurani, Lalit

AU - Zimmermann, Jörg

AU - Wiltfang, Jens

AU - von Hagen, Martin

AU - Vogl, Thomas

AU - Spitzer, Carsten

AU - Senner, Simon

AU - Schulte, Eva C

AU - Schmauß, Max

AU - Schaupp, Sabrina K

AU - Reimer, Jens

AU - Reich-Erkelenz, Daniela

AU - Papiol, Sergi

AU - Kohshour, Mojtaba Oraki

AU - Lang, Fabian U

AU - Konrad, Carsten

AU - Kirchner, Sophie-Kathrin

AU - Kalman, Janos L

AU - Juckel, Georg

AU - Heilbronner, Maria

AU - Heilbronner, Urs

AU - Figge, Christian

AU - Eyl, Ruth E

AU - Dietrich, Detlef

AU - Budde, Monika

AU - Angelescu, Ion-George

AU - Adorjan, Kristina

AU - Schmitt, Andrea

AU - Fischer, Andre

AU - Falkai, Peter

AU - Schulze, Thomas G

N1 - © 2023 The Authors. Published by Elsevier Inc.

PY - 2023/6

Y1 - 2023/6

N2 - As core symptoms of schizophrenia, cognitive deficits contribute substantially to poor outcomes. Early life stress (ELS) can negatively affect cognition in patients with schizophrenia and healthy controls, but the exact nature of the mediating factors is unclear. Therefore, we investigated how ELS, education, and symptom burden are related to cognitive performance. The sample comprised 215 patients with schizophrenia (age, 42.9 ± 12.0 years; 66.0 % male) and 197 healthy controls (age, 38.5 ± 16.4 years; 39.3 % male) from the PsyCourse Study. ELS was assessed with the Childhood Trauma Screener (CTS). We used analyses of covariance and correlation analyses to investigate the association of total ELS load and ELS subtypes with cognitive performance. ELS was reported by 52.1 % of patients and 24.9 % of controls. Independent of ELS, cognitive performance on neuropsychological tests was lower in patients than controls (p < 0.001). ELS load was more closely associated with neurocognitive deficits (cognitive composite score) in controls (r = -0.305, p < 0.001) than in patients (r = -0.163, p = 0.033). Moreover, the higher the ELS load, the more cognitive deficits were found in controls (r = -0.200, p = 0.006), while in patients, this correlation was not significant after adjusting for PANSS. ELS load was more strongly associated with cognitive deficits in healthy controls than in patients. In patients, disease-related positive and negative symptoms may mask the effects of ELS-related cognitive deficits. ELS subtypes were associated with impairments in various cognitive domains. Cognitive deficits appear to be mediated through higher symptom burden and lower educational level.

AB - As core symptoms of schizophrenia, cognitive deficits contribute substantially to poor outcomes. Early life stress (ELS) can negatively affect cognition in patients with schizophrenia and healthy controls, but the exact nature of the mediating factors is unclear. Therefore, we investigated how ELS, education, and symptom burden are related to cognitive performance. The sample comprised 215 patients with schizophrenia (age, 42.9 ± 12.0 years; 66.0 % male) and 197 healthy controls (age, 38.5 ± 16.4 years; 39.3 % male) from the PsyCourse Study. ELS was assessed with the Childhood Trauma Screener (CTS). We used analyses of covariance and correlation analyses to investigate the association of total ELS load and ELS subtypes with cognitive performance. ELS was reported by 52.1 % of patients and 24.9 % of controls. Independent of ELS, cognitive performance on neuropsychological tests was lower in patients than controls (p < 0.001). ELS load was more closely associated with neurocognitive deficits (cognitive composite score) in controls (r = -0.305, p < 0.001) than in patients (r = -0.163, p = 0.033). Moreover, the higher the ELS load, the more cognitive deficits were found in controls (r = -0.200, p = 0.006), while in patients, this correlation was not significant after adjusting for PANSS. ELS load was more strongly associated with cognitive deficits in healthy controls than in patients. In patients, disease-related positive and negative symptoms may mask the effects of ELS-related cognitive deficits. ELS subtypes were associated with impairments in various cognitive domains. Cognitive deficits appear to be mediated through higher symptom burden and lower educational level.

U2 - 10.1016/j.scog.2023.100280

DO - 10.1016/j.scog.2023.100280

M3 - SCORING: Journal article

C2 - 36846489

VL - 32

SP - 100280

JO - SCHIZOPHR RES-COGN

JF - SCHIZOPHR RES-COGN

SN - 2215-0013

ER -