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Association of Cortical Glutamate and Working Memory Activation in Patients With Schizophrenia. A Multimodal Proton Magnetic Resonance Spectroscopy and Functional Magnetic Resonance Imaging Study

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Association of Cortical Glutamate and Working Memory Activation in Patients With Schizophrenia. A Multimodal Proton Magnetic Resonance Spectroscopy and Functional Magnetic Resonance Imaging Study. / Kaminski, Jakob; Gleich, Tobias; Fukuda, Yu; Katthagen, Teresa; Gallinat, Jürgen; Heinz, Andreas; Schlagenhauf, Florian.

In: BIOL PSYCHIAT, Vol. 87, No. 3, 01.02.2020, p. 225-233.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kaminski, J, Gleich, T, Fukuda, Y, Katthagen, T, Gallinat, J, Heinz, A & Schlagenhauf, F 2020, 'Association of Cortical Glutamate and Working Memory Activation in Patients With Schizophrenia. A Multimodal Proton Magnetic Resonance Spectroscopy and Functional Magnetic Resonance Imaging Study', BIOL PSYCHIAT, vol. 87, no. 3, pp. 225-233. https://doi.org/10.1016/j.biopsych.2019.07.011

APA

Kaminski, J., Gleich, T., Fukuda, Y., Katthagen, T., Gallinat, J., Heinz, A., & Schlagenhauf, F. (2020). Association of Cortical Glutamate and Working Memory Activation in Patients With Schizophrenia. A Multimodal Proton Magnetic Resonance Spectroscopy and Functional Magnetic Resonance Imaging Study. BIOL PSYCHIAT, 87(3), 225-233. https://doi.org/10.1016/j.biopsych.2019.07.011

Vancouver

Kaminski J, Gleich T, Fukuda Y, Katthagen T, Gallinat J, Heinz A et al. Association of Cortical Glutamate and Working Memory Activation in Patients With Schizophrenia. A Multimodal Proton Magnetic Resonance Spectroscopy and Functional Magnetic Resonance Imaging Study. BIOL PSYCHIAT. 2020 Feb 1;87(3):225-233. https://doi.org/10.1016/j.biopsych.2019.07.011

Bibtex

@article{b4ab54d3b64148b69f44ed8aed8c66d1,
title = "Association of Cortical Glutamate and Working Memory Activation in Patients With Schizophrenia. A Multimodal Proton Magnetic Resonance Spectroscopy and Functional Magnetic Resonance Imaging Study",
abstract = "BACKGROUND: Cognitive deficits such as working memory (WM) impairment are core features of schizophrenia. One candidate marker for the integrity of synaptic neurotransmission necessary for cognitive processes is glutamate. It is frequently postulated that antipsychotic medication possibly alters functional mechanisms in the living brain. We tested in vivo for group differences in activation of the dorsolateral prefrontal cortex (DLPFC) during WM performance and the association with glutamate concentration in DLPFC depending on medication status.METHODS: A total of 90 subjects (35 control subjects, 36 medicated patients, and 19 unmedicated patients) contributed magnetic resonance spectroscopy data. We estimated glutamate in left DLPFC. Subjects performed an n-back WM task (2-back vs. 0-back) during functional magnetic resonance imaging, and local activation in left DLPFC was measured. For analysis of association with medication status, we calculated linear regression models including an interaction effect with group.RESULTS: Medicated and unmedicated patients with schizophrenia showed impaired performance. We found significantly reduced WM activation in left DLPFC in medicated patients and a trendwise reduction in unmedicated patients as compared with control subjects. We found no group difference in local glutamate concentration. However, we found differential effects of medication status on the association between local glutamate concentration and WM activation in left DLPFC, with a positive association in unmedicated patients but not in medicated patients.CONCLUSIONS: We provide evidence that WM-dependent activation is associated with glutamate concentration in unmedicated patients with schizophrenia. Our finding points to putative allostatic changes that affect the functioning of the brain and might be altered through medication.",
author = "Jakob Kaminski and Tobias Gleich and Yu Fukuda and Teresa Katthagen and J{\"u}rgen Gallinat and Andreas Heinz and Florian Schlagenhauf",
note = "Copyright {\textcopyright} 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = feb,
day = "1",
doi = "10.1016/j.biopsych.2019.07.011",
language = "English",
volume = "87",
pages = "225--233",
journal = "BIOL PSYCHIAT",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "3",

}

RIS

TY - JOUR

T1 - Association of Cortical Glutamate and Working Memory Activation in Patients With Schizophrenia. A Multimodal Proton Magnetic Resonance Spectroscopy and Functional Magnetic Resonance Imaging Study

AU - Kaminski, Jakob

AU - Gleich, Tobias

AU - Fukuda, Yu

AU - Katthagen, Teresa

AU - Gallinat, Jürgen

AU - Heinz, Andreas

AU - Schlagenhauf, Florian

N1 - Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - BACKGROUND: Cognitive deficits such as working memory (WM) impairment are core features of schizophrenia. One candidate marker for the integrity of synaptic neurotransmission necessary for cognitive processes is glutamate. It is frequently postulated that antipsychotic medication possibly alters functional mechanisms in the living brain. We tested in vivo for group differences in activation of the dorsolateral prefrontal cortex (DLPFC) during WM performance and the association with glutamate concentration in DLPFC depending on medication status.METHODS: A total of 90 subjects (35 control subjects, 36 medicated patients, and 19 unmedicated patients) contributed magnetic resonance spectroscopy data. We estimated glutamate in left DLPFC. Subjects performed an n-back WM task (2-back vs. 0-back) during functional magnetic resonance imaging, and local activation in left DLPFC was measured. For analysis of association with medication status, we calculated linear regression models including an interaction effect with group.RESULTS: Medicated and unmedicated patients with schizophrenia showed impaired performance. We found significantly reduced WM activation in left DLPFC in medicated patients and a trendwise reduction in unmedicated patients as compared with control subjects. We found no group difference in local glutamate concentration. However, we found differential effects of medication status on the association between local glutamate concentration and WM activation in left DLPFC, with a positive association in unmedicated patients but not in medicated patients.CONCLUSIONS: We provide evidence that WM-dependent activation is associated with glutamate concentration in unmedicated patients with schizophrenia. Our finding points to putative allostatic changes that affect the functioning of the brain and might be altered through medication.

AB - BACKGROUND: Cognitive deficits such as working memory (WM) impairment are core features of schizophrenia. One candidate marker for the integrity of synaptic neurotransmission necessary for cognitive processes is glutamate. It is frequently postulated that antipsychotic medication possibly alters functional mechanisms in the living brain. We tested in vivo for group differences in activation of the dorsolateral prefrontal cortex (DLPFC) during WM performance and the association with glutamate concentration in DLPFC depending on medication status.METHODS: A total of 90 subjects (35 control subjects, 36 medicated patients, and 19 unmedicated patients) contributed magnetic resonance spectroscopy data. We estimated glutamate in left DLPFC. Subjects performed an n-back WM task (2-back vs. 0-back) during functional magnetic resonance imaging, and local activation in left DLPFC was measured. For analysis of association with medication status, we calculated linear regression models including an interaction effect with group.RESULTS: Medicated and unmedicated patients with schizophrenia showed impaired performance. We found significantly reduced WM activation in left DLPFC in medicated patients and a trendwise reduction in unmedicated patients as compared with control subjects. We found no group difference in local glutamate concentration. However, we found differential effects of medication status on the association between local glutamate concentration and WM activation in left DLPFC, with a positive association in unmedicated patients but not in medicated patients.CONCLUSIONS: We provide evidence that WM-dependent activation is associated with glutamate concentration in unmedicated patients with schizophrenia. Our finding points to putative allostatic changes that affect the functioning of the brain and might be altered through medication.

U2 - 10.1016/j.biopsych.2019.07.011

DO - 10.1016/j.biopsych.2019.07.011

M3 - SCORING: Journal article

C2 - 31521336

VL - 87

SP - 225

EP - 233

JO - BIOL PSYCHIAT

JF - BIOL PSYCHIAT

SN - 0006-3223

IS - 3

ER -