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Association of body mass index with colorectal cancer risk by genome-wide variants

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Association of body mass index with colorectal cancer risk by genome-wide variants. / Campbell, Peter T; Lin, Yi; Bien, Stephanie A; Figueiredo, Jane C; Harrison, Tabitha A; Guinter, Mark J; Berndt, Sonja I; Brenner, Hermann; Chan, Andrew T; Chang-Claude, Jenny; Gallinger, Steven J; Gapstur, Susan M; Giles, Graham G; Giovannucci, Edward; Gruber, Stephen B; Gunter, Marc; Hoffmeister, Michael; Jacobs, Eric J; Jenkins, Mark A; Marchand, Loic Le; Li, Li; McLaughlin, John R; Murphy, Neil; Milne, Roger L; Newcomb, Polly A; Newton, Christina; Ogino, Shuji; Potter, John D; Rennert, Gad; Rennert, Hedy S; Robinson, Jennifer; Sakoda, Lori C; Slattery, Martha L; Song, Yiqing; White, Emily; Woods, Michael O; Casey, Graham; Hsu, Li.

In: JNCI-J NATL CANCER I, Vol. 113, No. 1, 04.01.2021, p. 38-47.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Campbell, PT, Lin, Y, Bien, SA, Figueiredo, JC, Harrison, TA, Guinter, MJ, Berndt, SI, Brenner, H, Chan, AT, Chang-Claude, J, Gallinger, SJ, Gapstur, SM, Giles, GG, Giovannucci, E, Gruber, SB, Gunter, M, Hoffmeister, M, Jacobs, EJ, Jenkins, MA, Marchand, LL, Li, L, McLaughlin, JR, Murphy, N, Milne, RL, Newcomb, PA, Newton, C, Ogino, S, Potter, JD, Rennert, G, Rennert, HS, Robinson, J, Sakoda, LC, Slattery, ML, Song, Y, White, E, Woods, MO, Casey, G & Hsu, L 2021, 'Association of body mass index with colorectal cancer risk by genome-wide variants', JNCI-J NATL CANCER I, vol. 113, no. 1, pp. 38-47. https://doi.org/10.1093/jnci/djaa058

APA

Campbell, P. T., Lin, Y., Bien, S. A., Figueiredo, J. C., Harrison, T. A., Guinter, M. J., Berndt, S. I., Brenner, H., Chan, A. T., Chang-Claude, J., Gallinger, S. J., Gapstur, S. M., Giles, G. G., Giovannucci, E., Gruber, S. B., Gunter, M., Hoffmeister, M., Jacobs, E. J., Jenkins, M. A., ... Hsu, L. (2021). Association of body mass index with colorectal cancer risk by genome-wide variants. JNCI-J NATL CANCER I, 113(1), 38-47. https://doi.org/10.1093/jnci/djaa058

Vancouver

Campbell PT, Lin Y, Bien SA, Figueiredo JC, Harrison TA, Guinter MJ et al. Association of body mass index with colorectal cancer risk by genome-wide variants. JNCI-J NATL CANCER I. 2021 Jan 4;113(1):38-47. https://doi.org/10.1093/jnci/djaa058

Bibtex

@article{7112caddbe2943ccbff42068d070a29e,
title = "Association of body mass index with colorectal cancer risk by genome-wide variants",
abstract = "BACKGROUND: Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer risk.METHODS: We tested multiplicative statistical interactions between BMI (per 5 kg/m2) and approximately 2.7 million single nucleotide polymorphisms with colorectal cancer risk among 14 059 colorectal cancer case (53.2% women) and 14 416 control (53.8% women) participants. All analyses were stratified by sex a priori. Statistical methods included 2-step (ie, Cocktail method) and single-step (ie, case-control logistic regression and a joint 2-degree of freedom test) procedures. All statistical tests were two-sided.RESULTS: Each 5 kg/m2 increase in BMI was associated with higher risks of colorectal cancer, less so for women (odds ratio [OR] = 1.14, 95% confidence intervals [CI] = 1.11 to 1.18; P = 9.75 × 10-17) than for men (OR = 1.26, 95% CI = 1.20 to 1.32; P = 2.13 × 10-24). The 2-step Cocktail method identified an interaction for women, but not men, between BMI and a SMAD7 intronic variant at 18q21.1 (rs4939827; Pobserved = .0009; Pthreshold = .005). A joint 2-degree of freedom test was consistent with this finding for women (joint P = 2.43 × 10-10). Each 5 kg/m2 increase in BMI was more strongly associated with colorectal cancer risk for women with the rs4939827-CC genotype (OR = 1.24, 95% CI = 1.16 to 1.32; P = 2.60 × 10-10) than for women with the CT (OR = 1.14, 95% CI = 1.09 to 1.19; P = 1.04 × 10-8) or TT (OR = 1.07, 95% CI = 1.01 to 1.14; P = .02) genotypes.CONCLUSION: These results provide novel insights on a potential mechanism through which a SMAD7 variant, previously identified as a susceptibility locus for colorectal cancer, and BMI may influence colorectal cancer risk for women.",
author = "Campbell, {Peter T} and Yi Lin and Bien, {Stephanie A} and Figueiredo, {Jane C} and Harrison, {Tabitha A} and Guinter, {Mark J} and Berndt, {Sonja I} and Hermann Brenner and Chan, {Andrew T} and Jenny Chang-Claude and Gallinger, {Steven J} and Gapstur, {Susan M} and Giles, {Graham G} and Edward Giovannucci and Gruber, {Stephen B} and Marc Gunter and Michael Hoffmeister and Jacobs, {Eric J} and Jenkins, {Mark A} and Marchand, {Loic Le} and Li Li and McLaughlin, {John R} and Neil Murphy and Milne, {Roger L} and Newcomb, {Polly A} and Christina Newton and Shuji Ogino and Potter, {John D} and Gad Rennert and Rennert, {Hedy S} and Jennifer Robinson and Sakoda, {Lori C} and Slattery, {Martha L} and Yiqing Song and Emily White and Woods, {Michael O} and Graham Casey and Li Hsu",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.",
year = "2021",
month = jan,
day = "4",
doi = "10.1093/jnci/djaa058",
language = "English",
volume = "113",
pages = "38--47",
journal = "JNCI-J NATL CANCER I",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Association of body mass index with colorectal cancer risk by genome-wide variants

AU - Campbell, Peter T

AU - Lin, Yi

AU - Bien, Stephanie A

AU - Figueiredo, Jane C

AU - Harrison, Tabitha A

AU - Guinter, Mark J

AU - Berndt, Sonja I

AU - Brenner, Hermann

AU - Chan, Andrew T

AU - Chang-Claude, Jenny

AU - Gallinger, Steven J

AU - Gapstur, Susan M

AU - Giles, Graham G

AU - Giovannucci, Edward

AU - Gruber, Stephen B

AU - Gunter, Marc

AU - Hoffmeister, Michael

AU - Jacobs, Eric J

AU - Jenkins, Mark A

AU - Marchand, Loic Le

AU - Li, Li

AU - McLaughlin, John R

AU - Murphy, Neil

AU - Milne, Roger L

AU - Newcomb, Polly A

AU - Newton, Christina

AU - Ogino, Shuji

AU - Potter, John D

AU - Rennert, Gad

AU - Rennert, Hedy S

AU - Robinson, Jennifer

AU - Sakoda, Lori C

AU - Slattery, Martha L

AU - Song, Yiqing

AU - White, Emily

AU - Woods, Michael O

AU - Casey, Graham

AU - Hsu, Li

N1 - © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2021/1/4

Y1 - 2021/1/4

N2 - BACKGROUND: Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer risk.METHODS: We tested multiplicative statistical interactions between BMI (per 5 kg/m2) and approximately 2.7 million single nucleotide polymorphisms with colorectal cancer risk among 14 059 colorectal cancer case (53.2% women) and 14 416 control (53.8% women) participants. All analyses were stratified by sex a priori. Statistical methods included 2-step (ie, Cocktail method) and single-step (ie, case-control logistic regression and a joint 2-degree of freedom test) procedures. All statistical tests were two-sided.RESULTS: Each 5 kg/m2 increase in BMI was associated with higher risks of colorectal cancer, less so for women (odds ratio [OR] = 1.14, 95% confidence intervals [CI] = 1.11 to 1.18; P = 9.75 × 10-17) than for men (OR = 1.26, 95% CI = 1.20 to 1.32; P = 2.13 × 10-24). The 2-step Cocktail method identified an interaction for women, but not men, between BMI and a SMAD7 intronic variant at 18q21.1 (rs4939827; Pobserved = .0009; Pthreshold = .005). A joint 2-degree of freedom test was consistent with this finding for women (joint P = 2.43 × 10-10). Each 5 kg/m2 increase in BMI was more strongly associated with colorectal cancer risk for women with the rs4939827-CC genotype (OR = 1.24, 95% CI = 1.16 to 1.32; P = 2.60 × 10-10) than for women with the CT (OR = 1.14, 95% CI = 1.09 to 1.19; P = 1.04 × 10-8) or TT (OR = 1.07, 95% CI = 1.01 to 1.14; P = .02) genotypes.CONCLUSION: These results provide novel insights on a potential mechanism through which a SMAD7 variant, previously identified as a susceptibility locus for colorectal cancer, and BMI may influence colorectal cancer risk for women.

AB - BACKGROUND: Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer risk.METHODS: We tested multiplicative statistical interactions between BMI (per 5 kg/m2) and approximately 2.7 million single nucleotide polymorphisms with colorectal cancer risk among 14 059 colorectal cancer case (53.2% women) and 14 416 control (53.8% women) participants. All analyses were stratified by sex a priori. Statistical methods included 2-step (ie, Cocktail method) and single-step (ie, case-control logistic regression and a joint 2-degree of freedom test) procedures. All statistical tests were two-sided.RESULTS: Each 5 kg/m2 increase in BMI was associated with higher risks of colorectal cancer, less so for women (odds ratio [OR] = 1.14, 95% confidence intervals [CI] = 1.11 to 1.18; P = 9.75 × 10-17) than for men (OR = 1.26, 95% CI = 1.20 to 1.32; P = 2.13 × 10-24). The 2-step Cocktail method identified an interaction for women, but not men, between BMI and a SMAD7 intronic variant at 18q21.1 (rs4939827; Pobserved = .0009; Pthreshold = .005). A joint 2-degree of freedom test was consistent with this finding for women (joint P = 2.43 × 10-10). Each 5 kg/m2 increase in BMI was more strongly associated with colorectal cancer risk for women with the rs4939827-CC genotype (OR = 1.24, 95% CI = 1.16 to 1.32; P = 2.60 × 10-10) than for women with the CT (OR = 1.14, 95% CI = 1.09 to 1.19; P = 1.04 × 10-8) or TT (OR = 1.07, 95% CI = 1.01 to 1.14; P = .02) genotypes.CONCLUSION: These results provide novel insights on a potential mechanism through which a SMAD7 variant, previously identified as a susceptibility locus for colorectal cancer, and BMI may influence colorectal cancer risk for women.

U2 - 10.1093/jnci/djaa058

DO - 10.1093/jnci/djaa058

M3 - SCORING: Journal article

C2 - 32324875

VL - 113

SP - 38

EP - 47

JO - JNCI-J NATL CANCER I

JF - JNCI-J NATL CANCER I

SN - 0027-8874

IS - 1

ER -