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Association between vmPFC gray matter volume and smoking initiation in adolescents

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Association between vmPFC gray matter volume and smoking initiation in adolescents. / Xiang, Shitong; Jia, Tianye; Xie, Chao; Cheng, Wei; Chaarani, Bader; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Büchel, Christian; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Gowland, Penny A; Brühl, Rüdiger; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Poustka, Luise; Hohmann, Sarah; Fröhner, Juliane H; Smolka, Michael N; Vaidya, Nilakshi; Walter, Henrik; Whelan, Robert; Garavan, Hugh; Schumann, Gunter; Sahakian, Barbara J; Robbins, Trevor W; Feng, Jianfeng; IMAGEN Consortium.

In: NAT COMMUN, Vol. 14, No. 1, 15.08.2023, p. 4684.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Xiang, S, Jia, T, Xie, C, Cheng, W, Chaarani, B, Banaschewski, T, Barker, GJ, Bokde, ALW, Büchel, C, Desrivières, S, Flor, H, Grigis, A, Gowland, PA, Brühl, R, Martinot, J-L, Martinot, M-LP, Nees, F, Orfanos, DP, Poustka, L, Hohmann, S, Fröhner, JH, Smolka, MN, Vaidya, N, Walter, H, Whelan, R, Garavan, H, Schumann, G, Sahakian, BJ, Robbins, TW, Feng, J & IMAGEN Consortium 2023, 'Association between vmPFC gray matter volume and smoking initiation in adolescents', NAT COMMUN, vol. 14, no. 1, pp. 4684. https://doi.org/10.1038/s41467-023-40079-2

APA

Xiang, S., Jia, T., Xie, C., Cheng, W., Chaarani, B., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., Desrivières, S., Flor, H., Grigis, A., Gowland, P. A., Brühl, R., Martinot, J-L., Martinot, M-L. P., Nees, F., Orfanos, D. P., Poustka, L., ... IMAGEN Consortium (2023). Association between vmPFC gray matter volume and smoking initiation in adolescents. NAT COMMUN, 14(1), 4684. https://doi.org/10.1038/s41467-023-40079-2

Vancouver

Xiang S, Jia T, Xie C, Cheng W, Chaarani B, Banaschewski T et al. Association between vmPFC gray matter volume and smoking initiation in adolescents. NAT COMMUN. 2023 Aug 15;14(1):4684. https://doi.org/10.1038/s41467-023-40079-2

Bibtex

@article{17dd5d5761aa42ae9eebaca1d85be4ff,
title = "Association between vmPFC gray matter volume and smoking initiation in adolescents",
abstract = "Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.",
keywords = "Humans, Adolescent, Gray Matter/diagnostic imaging, Magnetic Resonance Imaging/methods, Prefrontal Cortex/diagnostic imaging, Smoking/adverse effects, Tobacco Use Disorder, Brain",
author = "Shitong Xiang and Tianye Jia and Chao Xie and Wei Cheng and Bader Chaarani and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Christian B{\"u}chel and Sylvane Desrivi{\`e}res and Herta Flor and Antoine Grigis and Gowland, {Penny A} and R{\"u}diger Br{\"u}hl and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Luise Poustka and Sarah Hohmann and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Nilakshi Vaidya and Henrik Walter and Robert Whelan and Hugh Garavan and Gunter Schumann and Sahakian, {Barbara J} and Robbins, {Trevor W} and Jianfeng Feng and {IMAGEN Consortium}",
note = "{\textcopyright} 2023. Springer Nature Limited.",
year = "2023",
month = aug,
day = "15",
doi = "10.1038/s41467-023-40079-2",
language = "English",
volume = "14",
pages = "4684",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Association between vmPFC gray matter volume and smoking initiation in adolescents

AU - Xiang, Shitong

AU - Jia, Tianye

AU - Xie, Chao

AU - Cheng, Wei

AU - Chaarani, Bader

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Büchel, Christian

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Grigis, Antoine

AU - Gowland, Penny A

AU - Brühl, Rüdiger

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Poustka, Luise

AU - Hohmann, Sarah

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Vaidya, Nilakshi

AU - Walter, Henrik

AU - Whelan, Robert

AU - Garavan, Hugh

AU - Schumann, Gunter

AU - Sahakian, Barbara J

AU - Robbins, Trevor W

AU - Feng, Jianfeng

AU - IMAGEN Consortium

N1 - © 2023. Springer Nature Limited.

PY - 2023/8/15

Y1 - 2023/8/15

N2 - Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.

AB - Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.

KW - Humans

KW - Adolescent

KW - Gray Matter/diagnostic imaging

KW - Magnetic Resonance Imaging/methods

KW - Prefrontal Cortex/diagnostic imaging

KW - Smoking/adverse effects

KW - Tobacco Use Disorder

KW - Brain

U2 - 10.1038/s41467-023-40079-2

DO - 10.1038/s41467-023-40079-2

M3 - SCORING: Journal article

C2 - 37582920

VL - 14

SP - 4684

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -