Association between periodontal disease and microstructural brain alterations in the Hamburg City Health Study
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Association between periodontal disease and microstructural brain alterations in the Hamburg City Health Study. / Mayer, Carola; Walther, Carolin; Borof, Katrin; Nägele, Felix L; Petersen, Marvin; Schell, Maximilian; Gerloff, Christian; Kühn, Simone; Heydecke, Guido; Beikler, Thomas; Cheng, Bastian; Thomalla, Götz; Aarabi, Ghazal.
In: J CLIN PERIODONTOL, 2024.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Association between periodontal disease and microstructural brain alterations in the Hamburg City Health Study
AU - Mayer, Carola
AU - Walther, Carolin
AU - Borof, Katrin
AU - Nägele, Felix L
AU - Petersen, Marvin
AU - Schell, Maximilian
AU - Gerloff, Christian
AU - Kühn, Simone
AU - Heydecke, Guido
AU - Beikler, Thomas
AU - Cheng, Bastian
AU - Thomalla, Götz
AU - Aarabi, Ghazal
N1 - © 2023 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
PY - 2024
Y1 - 2024
N2 - AIM: The aim of the PAROBRAIN study was to examine the association of periodontal health with microstructural white matter integrity and cerebral small vessel disease (CSVD) in the Hamburg City Health Study, a large population-based cohort with dental examination and brain magnetic resonance imaging (MRI).MATERIALS AND METHODS: Periodontal health was determined by measuring clinical attachment loss (CAL) and plaque index. Additionally, the decayed/missing/filled teeth (DMFT) index was quantified. 3D-FLAIR and 3D-T1-weighted images were used for white matter hyperintensity (WMH) segmentation. Diffusion-weighted MRI was used to quantify peak width of skeletonized mean diffusivity (PSMD).RESULTS: Data from 2030 participants were included in the analysis. Median age was 65 years, with 43% female participants. After adjusting for age and sex, an increase in WMH load was significantly associated with more CAL, higher plaque index and higher DMFT index. PSMD was significantly associated with the plaque index and DMFT. Additional adjustment for education and cardiovascular risk factors revealed a significant association of PSMD with plaque index (p < .001) and DMFT (p < .01), whereas effects of WMH load were attenuated (p > .05).CONCLUSIONS: These findings suggest an adverse effect of periodontal health on CSVD and white matter integrity. Further research is necessary to examine whether early treatment of periodontal disease can prevent microstructural brain damage.
AB - AIM: The aim of the PAROBRAIN study was to examine the association of periodontal health with microstructural white matter integrity and cerebral small vessel disease (CSVD) in the Hamburg City Health Study, a large population-based cohort with dental examination and brain magnetic resonance imaging (MRI).MATERIALS AND METHODS: Periodontal health was determined by measuring clinical attachment loss (CAL) and plaque index. Additionally, the decayed/missing/filled teeth (DMFT) index was quantified. 3D-FLAIR and 3D-T1-weighted images were used for white matter hyperintensity (WMH) segmentation. Diffusion-weighted MRI was used to quantify peak width of skeletonized mean diffusivity (PSMD).RESULTS: Data from 2030 participants were included in the analysis. Median age was 65 years, with 43% female participants. After adjusting for age and sex, an increase in WMH load was significantly associated with more CAL, higher plaque index and higher DMFT index. PSMD was significantly associated with the plaque index and DMFT. Additional adjustment for education and cardiovascular risk factors revealed a significant association of PSMD with plaque index (p < .001) and DMFT (p < .01), whereas effects of WMH load were attenuated (p > .05).CONCLUSIONS: These findings suggest an adverse effect of periodontal health on CSVD and white matter integrity. Further research is necessary to examine whether early treatment of periodontal disease can prevent microstructural brain damage.
U2 - 10.1111/jcpe.13828
DO - 10.1111/jcpe.13828
M3 - SCORING: Journal article
C2 - 37263624
JO - J CLIN PERIODONTOL
JF - J CLIN PERIODONTOL
SN - 0303-6979
ER -