Association Between Net Water Uptake and Functional Outcome in Patients With Low ASPECTS Brain Lesions
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Association Between Net Water Uptake and Functional Outcome in Patients With Low ASPECTS Brain Lesions : Results From the I-LAST Study. / Broocks, Gabriel; Meyer, Lukas; Elsayed, Sarah; McDonough, Rosalie; Bechstein, Matthias; Faizy, Tobias Djamsched; Sporns, Peter; Schön, Gerhard; Minnerup, Jens; Kniep, Helge C; Hanning, Uta; Barow, Ewgenia; Schramm, Peter; Langner, Soenke; Nawabi, Jawed; Papanagiotou, Panagiotis; Wintermark, Max; Lansberg, Maarten G; Albers, Gregory W; Heit, Jeremy J; Fiehler, Jens; Kemmling, Andre.
In: NEUROLOGY, Vol. 100, No. 9, 28.02.2023, p. e954-e963.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Association Between Net Water Uptake and Functional Outcome in Patients With Low ASPECTS Brain Lesions
T2 - Results From the I-LAST Study
AU - Broocks, Gabriel
AU - Meyer, Lukas
AU - Elsayed, Sarah
AU - McDonough, Rosalie
AU - Bechstein, Matthias
AU - Faizy, Tobias Djamsched
AU - Sporns, Peter
AU - Schön, Gerhard
AU - Minnerup, Jens
AU - Kniep, Helge C
AU - Hanning, Uta
AU - Barow, Ewgenia
AU - Schramm, Peter
AU - Langner, Soenke
AU - Nawabi, Jawed
AU - Papanagiotou, Panagiotis
AU - Wintermark, Max
AU - Lansberg, Maarten G
AU - Albers, Gregory W
AU - Heit, Jeremy J
AU - Fiehler, Jens
AU - Kemmling, Andre
N1 - © 2022 American Academy of Neurology.
PY - 2023/2/28
Y1 - 2023/2/28
N2 - BACKGROUND AND OBJECTIVES: The effect of mechanical thrombectomy (MT) on functional outcome in patients with ischemic stroke with low ASPECTS is still uncertain. ASPECTS rating is based on the presence of ischemic hypoattenuation relative to normal; however, the degree of hypoattenuation, which directly reflects net uptake of water, is currently not considered an imaging biomarker in stroke triage. We hypothesized that the effect of thrombectomy on functional outcome in low ASPECTS patients depends on early lesion water uptake.METHODS: For this multicenter observational study, patients with anterior circulation stroke with ASPECTS ≤5 were consecutively analyzed. Net water uptake (NWU) was assessed as a quantitative imaging biomarker in admission CT. The primary end point was the rate of favorable functional outcome defined as modified Rankin Scale score 0-3 at day 90. The effect of recanalization on functional outcome was analyzed according to the degree of NWU within the early infarct lesion.RESULTS: A total of 254 patients were included, of which 148 (58%) underwent MT. The median ASPECTS was 4 (interquartile range [IQR] 3-5), and the median NWU was 11.4% (IQR 8.9%-15.1%). The rate of favorable outcome was 27.6% in patients with low NWU (<11.4%) vs 6.3% in patients with high NWU (≥11.4%; p < 0.0001). In multivariable logistic regression analysis, NWU was an independent predictor of outcome, whereas vessel recanalization (modified thrombolysis in cerebral infarction ≥2b) was only significantly associated with better outcomes if NWU was lower than 12.6%. In inverse-probability weighting analysis, recanalization was associated with 20.7% (p = 0.01) increase in favorable outcome in patients with low NWU compared with 9.1% (p = 0.06) in patients with high NWU.DISCUSSION: Early NWU was independently associated with clinical outcome and might serve as an indicator of futile MT in low ASPECTS patients. NWU could be tested as a tool to select low ASPECTS patients for MT.TRIAL REGISTRATION INFORMATION: The study is registered within the ClinicalTrials.gov Protocol Registration and Results System (NCT04862507).
AB - BACKGROUND AND OBJECTIVES: The effect of mechanical thrombectomy (MT) on functional outcome in patients with ischemic stroke with low ASPECTS is still uncertain. ASPECTS rating is based on the presence of ischemic hypoattenuation relative to normal; however, the degree of hypoattenuation, which directly reflects net uptake of water, is currently not considered an imaging biomarker in stroke triage. We hypothesized that the effect of thrombectomy on functional outcome in low ASPECTS patients depends on early lesion water uptake.METHODS: For this multicenter observational study, patients with anterior circulation stroke with ASPECTS ≤5 were consecutively analyzed. Net water uptake (NWU) was assessed as a quantitative imaging biomarker in admission CT. The primary end point was the rate of favorable functional outcome defined as modified Rankin Scale score 0-3 at day 90. The effect of recanalization on functional outcome was analyzed according to the degree of NWU within the early infarct lesion.RESULTS: A total of 254 patients were included, of which 148 (58%) underwent MT. The median ASPECTS was 4 (interquartile range [IQR] 3-5), and the median NWU was 11.4% (IQR 8.9%-15.1%). The rate of favorable outcome was 27.6% in patients with low NWU (<11.4%) vs 6.3% in patients with high NWU (≥11.4%; p < 0.0001). In multivariable logistic regression analysis, NWU was an independent predictor of outcome, whereas vessel recanalization (modified thrombolysis in cerebral infarction ≥2b) was only significantly associated with better outcomes if NWU was lower than 12.6%. In inverse-probability weighting analysis, recanalization was associated with 20.7% (p = 0.01) increase in favorable outcome in patients with low NWU compared with 9.1% (p = 0.06) in patients with high NWU.DISCUSSION: Early NWU was independently associated with clinical outcome and might serve as an indicator of futile MT in low ASPECTS patients. NWU could be tested as a tool to select low ASPECTS patients for MT.TRIAL REGISTRATION INFORMATION: The study is registered within the ClinicalTrials.gov Protocol Registration and Results System (NCT04862507).
U2 - 10.1212/WNL.0000000000201601
DO - 10.1212/WNL.0000000000201601
M3 - SCORING: Journal article
C2 - 36414425
VL - 100
SP - e954-e963
JO - NEUROLOGY
JF - NEUROLOGY
SN - 0028-3878
IS - 9
ER -
