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Association between mitochondria-related genes and cognitive performance in the PsyCourse Study

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Association between mitochondria-related genes and cognitive performance in the PsyCourse Study. / Oraki Kohshour, Mojtaba; Schulte, Eva C; Heilbronner, Urs; Budde, Monika; Kalman, Janos L; Senner, Fanny; Heilbronner, Maria; Reich-Erkelenz, Daniela; Schaupp, Sabrina K; Vogl, Thomas; Adorjan, Kristina; Anghelescu, Ion-George; Arolt, Volker; Baune, Bernhardt T; Dannlowski, Udo; Dietrich, Detlef; Fallgatter, Andreas; Figge, Christian; Jäger, Markus; Lang, Fabian U; Juckel, Georg; Konrad, Carsten; Reimer, Jens; Reininghaus, Eva Z; Schmauß, Max; Spitzer, Carsten; von Hagen, Martin; Wiltfang, Jens; Zimmermann, Jörg; Andlauer, Till F M; Nöthen, Markus M; Degenhardt, Franziska; Forstner, Andreas J; Rietschel, Marcella; Witt, Stephanie H; Fischer, Andre; Falkai, Peter; Papiol, Sergi; Schulze, Thomas G.

In: J AFFECT DISORDERS, Vol. 325, 15.03.2023, p. 1-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Oraki Kohshour, M, Schulte, EC, Heilbronner, U, Budde, M, Kalman, JL, Senner, F, Heilbronner, M, Reich-Erkelenz, D, Schaupp, SK, Vogl, T, Adorjan, K, Anghelescu, I-G, Arolt, V, Baune, BT, Dannlowski, U, Dietrich, D, Fallgatter, A, Figge, C, Jäger, M, Lang, FU, Juckel, G, Konrad, C, Reimer, J, Reininghaus, EZ, Schmauß, M, Spitzer, C, von Hagen, M, Wiltfang, J, Zimmermann, J, Andlauer, TFM, Nöthen, MM, Degenhardt, F, Forstner, AJ, Rietschel, M, Witt, SH, Fischer, A, Falkai, P, Papiol, S & Schulze, TG 2023, 'Association between mitochondria-related genes and cognitive performance in the PsyCourse Study', J AFFECT DISORDERS, vol. 325, pp. 1-6. https://doi.org/10.1016/j.jad.2023.01.013

APA

Oraki Kohshour, M., Schulte, E. C., Heilbronner, U., Budde, M., Kalman, J. L., Senner, F., Heilbronner, M., Reich-Erkelenz, D., Schaupp, S. K., Vogl, T., Adorjan, K., Anghelescu, I-G., Arolt, V., Baune, B. T., Dannlowski, U., Dietrich, D., Fallgatter, A., Figge, C., Jäger, M., ... Schulze, T. G. (2023). Association between mitochondria-related genes and cognitive performance in the PsyCourse Study. J AFFECT DISORDERS, 325, 1-6. https://doi.org/10.1016/j.jad.2023.01.013

Vancouver

Oraki Kohshour M, Schulte EC, Heilbronner U, Budde M, Kalman JL, Senner F et al. Association between mitochondria-related genes and cognitive performance in the PsyCourse Study. J AFFECT DISORDERS. 2023 Mar 15;325:1-6. https://doi.org/10.1016/j.jad.2023.01.013

Bibtex

@article{6a130758d5544b37be92ae93c473f2a9,
title = "Association between mitochondria-related genes and cognitive performance in the PsyCourse Study",
abstract = "BACKGROUND: Mitochondria generate energy through oxidative phosphorylation (OXPHOS). The function of key OXPHOS proteins can be altered by variation in mitochondria-related genes, which may increase the risk of mental illness. We investigated the association of mitochondria-related genes and their genetic risk burden with cognitive performance.METHODS: We leveraged cross-sectional data from 1320 individuals with a severe psychiatric disorder and 466 neurotypical individuals from the PsyCourse Study. The cognitive tests analyzed were the Trail-Making Test, Verbal Digit Span Test, Digit-Symbol Test, and Multiple Choice Vocabulary Intelligence Test. Association analyses between the cognitive tests, and single-nucleotide polymorphisms (SNPs) mapped to mitochondria-related genes, and their polygenic risk score (PRS) for schizophrenia (SCZ) were performed with PLINK 1.9 and R program.RESULTS: We found a significant association (FDR-adjusted p < 0.05) in the Cytochrome C Oxidase Assembly Factor 8 (COA8) gene locus of the OXPHOS pathway with the Verbal Digit Span (forward) test. Mitochondrial PRS was not significantly associated with any of the cognitive tests.LIMITATIONS: Moderate statistical power due to relatively small sample size.CONCLUSIONS: COA8 encodes a poorly characterized mitochondrial protein involved in apoptosis. Here, this gene was associated with the Verbal Digit Span (forward) test, which evaluates short-term memory. Our results warrant replication and may lead to better understanding of cognitive impairment in mental disorders.",
keywords = "Humans, Cross-Sectional Studies, Schizophrenia/complications, Cognitive Dysfunction/genetics, Neuropsychological Tests, Cognition, Mitochondria/genetics",
author = "{Oraki Kohshour}, Mojtaba and Schulte, {Eva C} and Urs Heilbronner and Monika Budde and Kalman, {Janos L} and Fanny Senner and Maria Heilbronner and Daniela Reich-Erkelenz and Schaupp, {Sabrina K} and Thomas Vogl and Kristina Adorjan and Ion-George Anghelescu and Volker Arolt and Baune, {Bernhardt T} and Udo Dannlowski and Detlef Dietrich and Andreas Fallgatter and Christian Figge and Markus J{\"a}ger and Lang, {Fabian U} and Georg Juckel and Carsten Konrad and Jens Reimer and Reininghaus, {Eva Z} and Max Schmau{\ss} and Carsten Spitzer and {von Hagen}, Martin and Jens Wiltfang and J{\"o}rg Zimmermann and Andlauer, {Till F M} and N{\"o}then, {Markus M} and Franziska Degenhardt and Forstner, {Andreas J} and Marcella Rietschel and Witt, {Stephanie H} and Andre Fischer and Peter Falkai and Sergi Papiol and Schulze, {Thomas G}",
note = "Copyright {\textcopyright} 2023 Elsevier B.V. All rights reserved.",
year = "2023",
month = mar,
day = "15",
doi = "10.1016/j.jad.2023.01.013",
language = "English",
volume = "325",
pages = "1--6",
journal = "J AFFECT DISORDERS",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Association between mitochondria-related genes and cognitive performance in the PsyCourse Study

AU - Oraki Kohshour, Mojtaba

AU - Schulte, Eva C

AU - Heilbronner, Urs

AU - Budde, Monika

AU - Kalman, Janos L

AU - Senner, Fanny

AU - Heilbronner, Maria

AU - Reich-Erkelenz, Daniela

AU - Schaupp, Sabrina K

AU - Vogl, Thomas

AU - Adorjan, Kristina

AU - Anghelescu, Ion-George

AU - Arolt, Volker

AU - Baune, Bernhardt T

AU - Dannlowski, Udo

AU - Dietrich, Detlef

AU - Fallgatter, Andreas

AU - Figge, Christian

AU - Jäger, Markus

AU - Lang, Fabian U

AU - Juckel, Georg

AU - Konrad, Carsten

AU - Reimer, Jens

AU - Reininghaus, Eva Z

AU - Schmauß, Max

AU - Spitzer, Carsten

AU - von Hagen, Martin

AU - Wiltfang, Jens

AU - Zimmermann, Jörg

AU - Andlauer, Till F M

AU - Nöthen, Markus M

AU - Degenhardt, Franziska

AU - Forstner, Andreas J

AU - Rietschel, Marcella

AU - Witt, Stephanie H

AU - Fischer, Andre

AU - Falkai, Peter

AU - Papiol, Sergi

AU - Schulze, Thomas G

N1 - Copyright © 2023 Elsevier B.V. All rights reserved.

PY - 2023/3/15

Y1 - 2023/3/15

N2 - BACKGROUND: Mitochondria generate energy through oxidative phosphorylation (OXPHOS). The function of key OXPHOS proteins can be altered by variation in mitochondria-related genes, which may increase the risk of mental illness. We investigated the association of mitochondria-related genes and their genetic risk burden with cognitive performance.METHODS: We leveraged cross-sectional data from 1320 individuals with a severe psychiatric disorder and 466 neurotypical individuals from the PsyCourse Study. The cognitive tests analyzed were the Trail-Making Test, Verbal Digit Span Test, Digit-Symbol Test, and Multiple Choice Vocabulary Intelligence Test. Association analyses between the cognitive tests, and single-nucleotide polymorphisms (SNPs) mapped to mitochondria-related genes, and their polygenic risk score (PRS) for schizophrenia (SCZ) were performed with PLINK 1.9 and R program.RESULTS: We found a significant association (FDR-adjusted p < 0.05) in the Cytochrome C Oxidase Assembly Factor 8 (COA8) gene locus of the OXPHOS pathway with the Verbal Digit Span (forward) test. Mitochondrial PRS was not significantly associated with any of the cognitive tests.LIMITATIONS: Moderate statistical power due to relatively small sample size.CONCLUSIONS: COA8 encodes a poorly characterized mitochondrial protein involved in apoptosis. Here, this gene was associated with the Verbal Digit Span (forward) test, which evaluates short-term memory. Our results warrant replication and may lead to better understanding of cognitive impairment in mental disorders.

AB - BACKGROUND: Mitochondria generate energy through oxidative phosphorylation (OXPHOS). The function of key OXPHOS proteins can be altered by variation in mitochondria-related genes, which may increase the risk of mental illness. We investigated the association of mitochondria-related genes and their genetic risk burden with cognitive performance.METHODS: We leveraged cross-sectional data from 1320 individuals with a severe psychiatric disorder and 466 neurotypical individuals from the PsyCourse Study. The cognitive tests analyzed were the Trail-Making Test, Verbal Digit Span Test, Digit-Symbol Test, and Multiple Choice Vocabulary Intelligence Test. Association analyses between the cognitive tests, and single-nucleotide polymorphisms (SNPs) mapped to mitochondria-related genes, and their polygenic risk score (PRS) for schizophrenia (SCZ) were performed with PLINK 1.9 and R program.RESULTS: We found a significant association (FDR-adjusted p < 0.05) in the Cytochrome C Oxidase Assembly Factor 8 (COA8) gene locus of the OXPHOS pathway with the Verbal Digit Span (forward) test. Mitochondrial PRS was not significantly associated with any of the cognitive tests.LIMITATIONS: Moderate statistical power due to relatively small sample size.CONCLUSIONS: COA8 encodes a poorly characterized mitochondrial protein involved in apoptosis. Here, this gene was associated with the Verbal Digit Span (forward) test, which evaluates short-term memory. Our results warrant replication and may lead to better understanding of cognitive impairment in mental disorders.

KW - Humans

KW - Cross-Sectional Studies

KW - Schizophrenia/complications

KW - Cognitive Dysfunction/genetics

KW - Neuropsychological Tests

KW - Cognition

KW - Mitochondria/genetics

U2 - 10.1016/j.jad.2023.01.013

DO - 10.1016/j.jad.2023.01.013

M3 - SCORING: Journal article

C2 - 36621676

VL - 325

SP - 1

EP - 6

JO - J AFFECT DISORDERS

JF - J AFFECT DISORDERS

SN - 0165-0327

ER -