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Association between DRD2/ANKK1 TaqIA Allele Status and Striatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder

Standard

Association between DRD2/ANKK1 TaqIA Allele Status and Striatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder. / Spitta, Gianna; Fliedner, Lena E; Gleich, Tobias; Zindler, Tristan; Sebold, Miriam; Buchert, Ralph; Heinz, Andreas; Gallinat, Jürgen; Friedel, Eva.

In: J INTEGR NEUROSCI, Vol. 21, No. 6, 171, 28.10.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Spitta, G, Fliedner, LE, Gleich, T, Zindler, T, Sebold, M, Buchert, R, Heinz, A, Gallinat, J & Friedel, E 2022, 'Association between DRD2/ANKK1 TaqIA Allele Status and Striatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder', J INTEGR NEUROSCI, vol. 21, no. 6, 171. https://doi.org/10.31083/j.jin2106171

APA

Spitta, G., Fliedner, L. E., Gleich, T., Zindler, T., Sebold, M., Buchert, R., Heinz, A., Gallinat, J., & Friedel, E. (2022). Association between DRD2/ANKK1 TaqIA Allele Status and Striatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder. J INTEGR NEUROSCI, 21(6), [171]. https://doi.org/10.31083/j.jin2106171

Vancouver

Spitta G, Fliedner LE, Gleich T, Zindler T, Sebold M, Buchert R et al. Association between DRD2/ANKK1 TaqIA Allele Status and Striatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder. J INTEGR NEUROSCI. 2022 Oct 28;21(6). 171. https://doi.org/10.31083/j.jin2106171

Bibtex

@article{94a0e886ec654bf1a71a4d3f157c3dae,
title = "Association between DRD2/ANKK1 TaqIA Allele Status and Striatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder",
abstract = "BACKGROUND: The association between blunted dopaminergic neurotransmission and alcohol use disorder (AUD) is well-known. In particular, the impairment of postsynaptic dopamine 2 and 3 receptors (DRD2/3) in the ventral and dorsal striatum during the development and maintenance of alcohol addiction has been investigated in several positron emission tomography (PET) studies. However, it is unclear whether these changes are the result of adaptation or genetic predisposition.METHODS: Here we investigated the association between DRD2/ankyrin repeat and kinase domain-containing 1 (ANKK1) TaqIA allele (rs1800497) status and striatal DRD2/3 availability measured by 18F-fallypride PET in 12 AUD patients and 17 sex-matched healthy controls. Age and smoking status were included as covariates.RESULTS: Contrary to our expectations, TaqIA allele status was not associated with striatal DRD2/3 availability in either group and there was no significant difference between groups, possibly due to the relatively small sample size (N = 29).CONCLUSIONS: Nonetheless, this is the first in vivo study investigating the relationship between dopamine receptor availability and genetic factors in AUD. The pitfalls of assessing such relationships in a relatively small sample are discussed.CLINICAL TRIAL REGISTRATION: The published analysis is an additional, post hoc analysis to the preregistered trial with clinical trial number NCT01679145 available on https://clinical-trials.gov/ct2/show/NCT01679145.",
keywords = "Humans, Alcoholism/diagnostic imaging, Alleles, Corpus Striatum/diagnostic imaging, Dopamine, Positron-Emission Tomography, Protein Serine-Threonine Kinases/genetics, Receptors, Dopamine D2/genetics, Male, Female",
author = "Gianna Spitta and Fliedner, {Lena E} and Tobias Gleich and Tristan Zindler and Miriam Sebold and Ralph Buchert and Andreas Heinz and J{\"u}rgen Gallinat and Eva Friedel",
note = "{\textcopyright} 2022 The Author(s). Published by IMR Press.",
year = "2022",
month = oct,
day = "28",
doi = "10.31083/j.jin2106171",
language = "English",
volume = "21",
journal = "J INTEGR NEUROSCI",
issn = "0219-6352",
publisher = "World Scientific Publishing Co. Pte Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Association between DRD2/ANKK1 TaqIA Allele Status and Striatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder

AU - Spitta, Gianna

AU - Fliedner, Lena E

AU - Gleich, Tobias

AU - Zindler, Tristan

AU - Sebold, Miriam

AU - Buchert, Ralph

AU - Heinz, Andreas

AU - Gallinat, Jürgen

AU - Friedel, Eva

N1 - © 2022 The Author(s). Published by IMR Press.

PY - 2022/10/28

Y1 - 2022/10/28

N2 - BACKGROUND: The association between blunted dopaminergic neurotransmission and alcohol use disorder (AUD) is well-known. In particular, the impairment of postsynaptic dopamine 2 and 3 receptors (DRD2/3) in the ventral and dorsal striatum during the development and maintenance of alcohol addiction has been investigated in several positron emission tomography (PET) studies. However, it is unclear whether these changes are the result of adaptation or genetic predisposition.METHODS: Here we investigated the association between DRD2/ankyrin repeat and kinase domain-containing 1 (ANKK1) TaqIA allele (rs1800497) status and striatal DRD2/3 availability measured by 18F-fallypride PET in 12 AUD patients and 17 sex-matched healthy controls. Age and smoking status were included as covariates.RESULTS: Contrary to our expectations, TaqIA allele status was not associated with striatal DRD2/3 availability in either group and there was no significant difference between groups, possibly due to the relatively small sample size (N = 29).CONCLUSIONS: Nonetheless, this is the first in vivo study investigating the relationship between dopamine receptor availability and genetic factors in AUD. The pitfalls of assessing such relationships in a relatively small sample are discussed.CLINICAL TRIAL REGISTRATION: The published analysis is an additional, post hoc analysis to the preregistered trial with clinical trial number NCT01679145 available on https://clinical-trials.gov/ct2/show/NCT01679145.

AB - BACKGROUND: The association between blunted dopaminergic neurotransmission and alcohol use disorder (AUD) is well-known. In particular, the impairment of postsynaptic dopamine 2 and 3 receptors (DRD2/3) in the ventral and dorsal striatum during the development and maintenance of alcohol addiction has been investigated in several positron emission tomography (PET) studies. However, it is unclear whether these changes are the result of adaptation or genetic predisposition.METHODS: Here we investigated the association between DRD2/ankyrin repeat and kinase domain-containing 1 (ANKK1) TaqIA allele (rs1800497) status and striatal DRD2/3 availability measured by 18F-fallypride PET in 12 AUD patients and 17 sex-matched healthy controls. Age and smoking status were included as covariates.RESULTS: Contrary to our expectations, TaqIA allele status was not associated with striatal DRD2/3 availability in either group and there was no significant difference between groups, possibly due to the relatively small sample size (N = 29).CONCLUSIONS: Nonetheless, this is the first in vivo study investigating the relationship between dopamine receptor availability and genetic factors in AUD. The pitfalls of assessing such relationships in a relatively small sample are discussed.CLINICAL TRIAL REGISTRATION: The published analysis is an additional, post hoc analysis to the preregistered trial with clinical trial number NCT01679145 available on https://clinical-trials.gov/ct2/show/NCT01679145.

KW - Humans

KW - Alcoholism/diagnostic imaging

KW - Alleles

KW - Corpus Striatum/diagnostic imaging

KW - Dopamine

KW - Positron-Emission Tomography

KW - Protein Serine-Threonine Kinases/genetics

KW - Receptors, Dopamine D2/genetics

KW - Male

KW - Female

U2 - 10.31083/j.jin2106171

DO - 10.31083/j.jin2106171

M3 - SCORING: Journal article

C2 - 36424756

VL - 21

JO - J INTEGR NEUROSCI

JF - J INTEGR NEUROSCI

SN - 0219-6352

IS - 6

M1 - 171

ER -