Association between depression and subclinical carotid atherosclerosis in patients with Type 1 diabetes.
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Association between depression and subclinical carotid atherosclerosis in patients with Type 1 diabetes. / Spitzer, Carsten; Völzke, H; Barnow, S; Krohn, U; Wallaschofski, H; Lüdemann, J; John, U; Freyberger, H J; Kerner, W; Grabe, H J.
In: DIABETIC MED, Vol. 25, No. 3, 3, 2008, p. 349-354.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Association between depression and subclinical carotid atherosclerosis in patients with Type 1 diabetes.
AU - Spitzer, Carsten
AU - Völzke, H
AU - Barnow, S
AU - Krohn, U
AU - Wallaschofski, H
AU - Lüdemann, J
AU - John, U
AU - Freyberger, H J
AU - Kerner, W
AU - Grabe, H J
PY - 2008
Y1 - 2008
N2 - AIMS: Recent studies have suggested an association between depression and subclinical atherosclerosis as measured by presence of carotid atherosclerotic plaque and increased intima-media thickening in non-clinical populations. Given the high prevalence of depression in patients with Type 1 diabetes and the diabetes-related risk factors for atherosclerosis, we hypothesized that this relation might also be of special relevance in Type 1 diabetic patients. METHODS: Intima-media thickness (IMT) and the presence of plaques in the carotid arteries were quantitatively assessed by high-resolution ultrasound in 175 adults (89 men, 86 women) with an established diagnosis of Type 1 diabetes. Having been treated for depression or current Beck Depression Inventory scores > 10 were considered to indicate depression. RESULTS: In men, the risk of plaque was higher in depressed subjects relative to non-depressed participants after adjustment for age, smoking status, systolic blood pressure, dyslipidaemia and body mass index [odds ratio (OR) 5.19; 95% confidence interval (CI) 1.29, 20.81]. Depressed women did not have an increased risk of plaque compared with non-depressed women (OR 0.97; 95% 95% CI 0.22, 4.34). We did not observe an association between depression and IMT, in men or in women. CONCLUSIONS: In line with previous research, our findings suggest a link between depression and subclinical atherosclerosis in Type 1 diabetic men, but not in women.
AB - AIMS: Recent studies have suggested an association between depression and subclinical atherosclerosis as measured by presence of carotid atherosclerotic plaque and increased intima-media thickening in non-clinical populations. Given the high prevalence of depression in patients with Type 1 diabetes and the diabetes-related risk factors for atherosclerosis, we hypothesized that this relation might also be of special relevance in Type 1 diabetic patients. METHODS: Intima-media thickness (IMT) and the presence of plaques in the carotid arteries were quantitatively assessed by high-resolution ultrasound in 175 adults (89 men, 86 women) with an established diagnosis of Type 1 diabetes. Having been treated for depression or current Beck Depression Inventory scores > 10 were considered to indicate depression. RESULTS: In men, the risk of plaque was higher in depressed subjects relative to non-depressed participants after adjustment for age, smoking status, systolic blood pressure, dyslipidaemia and body mass index [odds ratio (OR) 5.19; 95% confidence interval (CI) 1.29, 20.81]. Depressed women did not have an increased risk of plaque compared with non-depressed women (OR 0.97; 95% 95% CI 0.22, 4.34). We did not observe an association between depression and IMT, in men or in women. CONCLUSIONS: In line with previous research, our findings suggest a link between depression and subclinical atherosclerosis in Type 1 diabetic men, but not in women.
M3 - SCORING: Zeitschriftenaufsatz
VL - 25
SP - 349
EP - 354
IS - 3
M1 - 3
ER -
