Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway
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Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway. / Luo, Qiang; Zhang, Lingli; Huang, Chu-Chung; Zheng, Yan; Kanen, Jonathan W; Zhao, Qi; Yao, Ye; Quinlan, Erin B; Jia, Tianye; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Poustka, Luise; Hohmann, Sarah; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Sahakian, Barbara J; Schumann, Gunter; Li, Fei; Feng, Jianfeng; Desrivières, Sylvane; Robbins, Trevor W; IMAGEN Consortium.
In: BMC MED, Vol. 18, No. 1, 15.10.2020, p. 278.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway
AU - Luo, Qiang
AU - Zhang, Lingli
AU - Huang, Chu-Chung
AU - Zheng, Yan
AU - Kanen, Jonathan W
AU - Zhao, Qi
AU - Yao, Ye
AU - Quinlan, Erin B
AU - Jia, Tianye
AU - Banaschewski, Tobias
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Flor, Herta
AU - Frouin, Vincent
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Martinot, Jean-Luc
AU - Martinot, Marie-Laure Paillère
AU - Nees, Frauke
AU - Orfanos, Dimitri Papadopoulos
AU - Poustka, Luise
AU - Hohmann, Sarah
AU - Fröhner, Juliane H
AU - Smolka, Michael N
AU - Walter, Henrik
AU - Whelan, Robert
AU - Sahakian, Barbara J
AU - Schumann, Gunter
AU - Li, Fei
AU - Feng, Jianfeng
AU - Desrivières, Sylvane
AU - Robbins, Trevor W
AU - IMAGEN Consortium
PY - 2020/10/15
Y1 - 2020/10/15
N2 - BACKGROUND: Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined.METHODS: Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry analysis of both childhood trauma and body mass index (BMI) was performed in the longitudinal IMAGEN cohort; validation of the findings was performed in the UKB. White-matter connectivity analysis was conducted to study the structural connectivity between the identified brain region and subdivisions of the hypothalamus in the HCP.RESULTS: In IMAGEN, a smaller frontopolar cortex (FPC) was associated with both childhood abuse (CA) (β = - .568, 95%CI - .942 to - .194; p = .003) and higher BMI (β = - .086, 95%CI - .128 to - .043; p < .001) in male participants, and these findings were validated in UKB. Across seven data collection sites, a stronger negative CA-FPC association was correlated with a higher positive CA-BMI association (β = - 1.033, 95%CI - 1.762 to - .305; p = .015). Using 7-T diffusion tensor imaging data (n = 156), we found that FPC was the third most connected cortical area with the hypothalamus, especially the lateral hypothalamus. A smaller FPC at age 14 contributed to higher BMI at age 19 in those male participants with a history of CA, and the CA-FPC interaction enabled a model at age 14 to account for some future weight gain during a 5-year follow-up (variance explained 5.8%).CONCLUSIONS: The findings highlight that a malfunctioning, top-down cognitive or behavioral control system, independent of genetic predisposition, putatively contributes to excessive weight gain in a particularly vulnerable population, and may inform treatment approaches.
AB - BACKGROUND: Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined.METHODS: Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry analysis of both childhood trauma and body mass index (BMI) was performed in the longitudinal IMAGEN cohort; validation of the findings was performed in the UKB. White-matter connectivity analysis was conducted to study the structural connectivity between the identified brain region and subdivisions of the hypothalamus in the HCP.RESULTS: In IMAGEN, a smaller frontopolar cortex (FPC) was associated with both childhood abuse (CA) (β = - .568, 95%CI - .942 to - .194; p = .003) and higher BMI (β = - .086, 95%CI - .128 to - .043; p < .001) in male participants, and these findings were validated in UKB. Across seven data collection sites, a stronger negative CA-FPC association was correlated with a higher positive CA-BMI association (β = - 1.033, 95%CI - 1.762 to - .305; p = .015). Using 7-T diffusion tensor imaging data (n = 156), we found that FPC was the third most connected cortical area with the hypothalamus, especially the lateral hypothalamus. A smaller FPC at age 14 contributed to higher BMI at age 19 in those male participants with a history of CA, and the CA-FPC interaction enabled a model at age 14 to account for some future weight gain during a 5-year follow-up (variance explained 5.8%).CONCLUSIONS: The findings highlight that a malfunctioning, top-down cognitive or behavioral control system, independent of genetic predisposition, putatively contributes to excessive weight gain in a particularly vulnerable population, and may inform treatment approaches.
KW - Adolescent
KW - Adult
KW - Body Mass Index
KW - Brain/pathology
KW - Child Abuse/psychology
KW - Female
KW - Genetic Predisposition to Disease
KW - Humans
KW - Longitudinal Studies
KW - Male
KW - Obesity/etiology
KW - Surveys and Questionnaires
KW - Weight Gain/physiology
KW - Young Adult
U2 - 10.1186/s12916-020-01743-2
DO - 10.1186/s12916-020-01743-2
M3 - SCORING: Journal article
C2 - 33054810
VL - 18
SP - 278
JO - BMC MED
JF - BMC MED
SN - 1741-7015
IS - 1
ER -
