Association between beta-blocker use and mortality/morbidity in older patients with heart failure with reduced ejection fraction. A propensity score-matched analysis from the Swedish Heart Failure Registry
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Association between beta-blocker use and mortality/morbidity in older patients with heart failure with reduced ejection fraction. A propensity score-matched analysis from the Swedish Heart Failure Registry. / Stolfo, Davide; Uijl, Alicia; Benson, Lina; Schrage, Benedikt; Fudim, Marat; Asselbergs, Folkert W; Koudstaal, Stefan; Sinagra, Gianfranco; Dahlström, Ulf; Rosano, Giuseppe; Savarese, Gianluigi.
In: EUR J HEART FAIL, Vol. 22, No. 1, 01.2020, p. 103-112.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Association between beta-blocker use and mortality/morbidity in older patients with heart failure with reduced ejection fraction. A propensity score-matched analysis from the Swedish Heart Failure Registry
AU - Stolfo, Davide
AU - Uijl, Alicia
AU - Benson, Lina
AU - Schrage, Benedikt
AU - Fudim, Marat
AU - Asselbergs, Folkert W
AU - Koudstaal, Stefan
AU - Sinagra, Gianfranco
AU - Dahlström, Ulf
AU - Rosano, Giuseppe
AU - Savarese, Gianluigi
N1 - © 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiology.
PY - 2020/1
Y1 - 2020/1
N2 - BACKGROUND: Beta-blockers reduce mortality and morbidity in heart failure (HF) with reduced ejection fraction (HFrEF). However, patients older than 80 years are poorly represented in randomized controlled trials. We assessed the association between beta-blocker use and outcomes in HFrEF patients aged ≥80 years.METHODS AND RESULTS: We included patients with an ejection fraction <40% and aged ≥80 years from the Swedish HF Registry. The association between beta-blocker use, all-cause mortality and cardiovascular (CV) mortality/HF hospitalization was assessed by Cox proportional hazard models in a 1:1 propensity score-matched cohort. To assess consistency, the same analyses were performed in a positive control cohort with age <80 years. A negative control outcome analysis was run using hospitalization for cancer as endpoint. Of 6562 patients aged ≥80 years, 5640 (86%) received beta-blockers. In the matched cohort including 1732 patients, beta-blocker use was associated with a significant reduction in the risk of all-cause mortality [hazard ratio (HR) 0.89, 95% confidence interval (CI) 0.79-0.99]. Reduction in CV mortality/HF hospitalization was not significant (HR 0.94, 95% CI 0.85-1.05) due to the lack of association with HF hospitalization, whereas CV death was significantly reduced. After adjustment rather than matching for the propensity score in the overall cohort, beta-blocker use was associated with reduced risk of all outcomes. In patients aged <80 years, use of beta-blockers was associated with reduced risk of all-cause death (HR 0.79, 95% CI 0.68-0.92) and of the composite outcome (HR 0.88, 95% CI 0.77-0.99).CONCLUSIONS: In HFrEF patients ≥80 years of age, use of beta-blockers was high and was associated with improved all-cause and CV survival.
AB - BACKGROUND: Beta-blockers reduce mortality and morbidity in heart failure (HF) with reduced ejection fraction (HFrEF). However, patients older than 80 years are poorly represented in randomized controlled trials. We assessed the association between beta-blocker use and outcomes in HFrEF patients aged ≥80 years.METHODS AND RESULTS: We included patients with an ejection fraction <40% and aged ≥80 years from the Swedish HF Registry. The association between beta-blocker use, all-cause mortality and cardiovascular (CV) mortality/HF hospitalization was assessed by Cox proportional hazard models in a 1:1 propensity score-matched cohort. To assess consistency, the same analyses were performed in a positive control cohort with age <80 years. A negative control outcome analysis was run using hospitalization for cancer as endpoint. Of 6562 patients aged ≥80 years, 5640 (86%) received beta-blockers. In the matched cohort including 1732 patients, beta-blocker use was associated with a significant reduction in the risk of all-cause mortality [hazard ratio (HR) 0.89, 95% confidence interval (CI) 0.79-0.99]. Reduction in CV mortality/HF hospitalization was not significant (HR 0.94, 95% CI 0.85-1.05) due to the lack of association with HF hospitalization, whereas CV death was significantly reduced. After adjustment rather than matching for the propensity score in the overall cohort, beta-blocker use was associated with reduced risk of all outcomes. In patients aged <80 years, use of beta-blockers was associated with reduced risk of all-cause death (HR 0.79, 95% CI 0.68-0.92) and of the composite outcome (HR 0.88, 95% CI 0.77-0.99).CONCLUSIONS: In HFrEF patients ≥80 years of age, use of beta-blockers was high and was associated with improved all-cause and CV survival.
KW - Aged
KW - Aged, 80 and over
KW - Heart Failure/drug therapy
KW - Hospitalization
KW - Humans
KW - Morbidity
KW - Propensity Score
KW - Registries
KW - Stroke Volume
KW - Sweden/epidemiology
U2 - 10.1002/ejhf.1615
DO - 10.1002/ejhf.1615
M3 - SCORING: Journal article
C2 - 31478583
VL - 22
SP - 103
EP - 112
JO - EUR J HEART FAIL
JF - EUR J HEART FAIL
SN - 1388-9842
IS - 1
ER -
