Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico-spinal fMRI study
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Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico-spinal fMRI study. / Braaß, Hanna; Feldheim, Jan-Frederik; Chu, Ying; Tinnermann, Alexandra; Finsterbusch, Jürgen; Büchel, Christian; Schulz, Robert; Gerloff, Christian.
In: HUM BRAIN MAPP, Vol. 44, No. 18, 15.12.2023, p. 6471-6483.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico-spinal fMRI study
AU - Braaß, Hanna
AU - Feldheim, Jan-Frederik
AU - Chu, Ying
AU - Tinnermann, Alexandra
AU - Finsterbusch, Jürgen
AU - Büchel, Christian
AU - Schulz, Robert
AU - Gerloff, Christian
PY - 2023/12/15
Y1 - 2023/12/15
N2 - Force generation is a crucial element of dexterity and a highly relevant skill of the human motor system. How cerebral and spinal components interact and how spinal activation is associated with the activity in the cerebral primary motor and premotor areas is poorly understood. Here, we conducted combined cortico-spinal functional magnetic resonance imaging during a simple visually guided isometric force generation task in 20 healthy young subjects. Activation was localized in the right cervical spinal cord and left primary motor and premotor areas. The main finding is that spinal activation was negatively correlated with ventral premotor cortex activation. Spinal activation was furthermore significantly correlated with primary motor cortex activation, while increasing target forces led to an increase in the amount of activation. These data indicate that human premotor areas such as the ventral premotor cortex might be functionally connected to the lower cervical spinal cord contributing to distal upper limb functions, a finding that extends our understanding of human motor function beyond the animal literature.
AB - Force generation is a crucial element of dexterity and a highly relevant skill of the human motor system. How cerebral and spinal components interact and how spinal activation is associated with the activity in the cerebral primary motor and premotor areas is poorly understood. Here, we conducted combined cortico-spinal functional magnetic resonance imaging during a simple visually guided isometric force generation task in 20 healthy young subjects. Activation was localized in the right cervical spinal cord and left primary motor and premotor areas. The main finding is that spinal activation was negatively correlated with ventral premotor cortex activation. Spinal activation was furthermore significantly correlated with primary motor cortex activation, while increasing target forces led to an increase in the amount of activation. These data indicate that human premotor areas such as the ventral premotor cortex might be functionally connected to the lower cervical spinal cord contributing to distal upper limb functions, a finding that extends our understanding of human motor function beyond the animal literature.
U2 - 10.1002/hbm.26523
DO - 10.1002/hbm.26523
M3 - SCORING: Journal article
C2 - 37873743
VL - 44
SP - 6471
EP - 6483
JO - HUM BRAIN MAPP
JF - HUM BRAIN MAPP
SN - 1065-9471
IS - 18
ER -
