Artificial intelligence and pathology: From principles to practice and future applications in histomorphology and molecular profiling
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Artificial intelligence and pathology: From principles to practice and future applications in histomorphology and molecular profiling. / Stenzinger, Albrecht; Alber, Maximilian; Allgäuer, Michael; Jurmeister, Philipp; Bockmayr, Michael; Budczies, Jan; Lennerz, Jochen; Eschrich, Johannes; Kazdal, Daniel; Schirmacher, Peter; Wagner, Alex H; Tacke, Frank; Capper, David; Müller, Klaus-Robert; Klauschen, Frederick.
In: SEMIN CANCER BIOL, Vol. 84, 09.2022, p. 129-143.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Artificial intelligence and pathology: From principles to practice and future applications in histomorphology and molecular profiling
AU - Stenzinger, Albrecht
AU - Alber, Maximilian
AU - Allgäuer, Michael
AU - Jurmeister, Philipp
AU - Bockmayr, Michael
AU - Budczies, Jan
AU - Lennerz, Jochen
AU - Eschrich, Johannes
AU - Kazdal, Daniel
AU - Schirmacher, Peter
AU - Wagner, Alex H
AU - Tacke, Frank
AU - Capper, David
AU - Müller, Klaus-Robert
AU - Klauschen, Frederick
N1 - Copyright © 2021 Elsevier Ltd. All rights reserved.
PY - 2022/9
Y1 - 2022/9
N2 - The complexity of diagnostic (surgical) pathology has increased substantially over the last decades with respect to histomorphological and molecular profiling. Pathology has steadily expanded its role in tumor diagnostics and beyond from disease entity identification via prognosis estimation to precision therapy prediction. It is therefore not surprising that pathology is among the disciplines in medicine with high expectations in the application of artificial intelligence (AI) or machine learning approaches given their capabilities to analyze complex data in a quantitative and standardized manner to further enhance scope and precision of diagnostics. While an obvious application is the analysis of histological images, recent applications for the analysis of molecular profiling data from different sources and clinical data support the notion that AI will enhance both histopathology and molecular pathology in the future. At the same time, current literature should not be misunderstood in a way that pathologists will likely be replaced by AI applications in the foreseeable future. Although AI will transform pathology in the coming years, recent studies reporting AI algorithms to diagnose cancer or predict certain molecular properties deal with relatively simple diagnostic problems that fall short of the diagnostic complexity pathologists face in clinical routine. Here, we review the pertinent literature of AI methods and their applications to pathology, and put the current achievements and what can be expected in the future in the context of the requirements for research and routine diagnostics.
AB - The complexity of diagnostic (surgical) pathology has increased substantially over the last decades with respect to histomorphological and molecular profiling. Pathology has steadily expanded its role in tumor diagnostics and beyond from disease entity identification via prognosis estimation to precision therapy prediction. It is therefore not surprising that pathology is among the disciplines in medicine with high expectations in the application of artificial intelligence (AI) or machine learning approaches given their capabilities to analyze complex data in a quantitative and standardized manner to further enhance scope and precision of diagnostics. While an obvious application is the analysis of histological images, recent applications for the analysis of molecular profiling data from different sources and clinical data support the notion that AI will enhance both histopathology and molecular pathology in the future. At the same time, current literature should not be misunderstood in a way that pathologists will likely be replaced by AI applications in the foreseeable future. Although AI will transform pathology in the coming years, recent studies reporting AI algorithms to diagnose cancer or predict certain molecular properties deal with relatively simple diagnostic problems that fall short of the diagnostic complexity pathologists face in clinical routine. Here, we review the pertinent literature of AI methods and their applications to pathology, and put the current achievements and what can be expected in the future in the context of the requirements for research and routine diagnostics.
U2 - 10.1016/j.semcancer.2021.02.011
DO - 10.1016/j.semcancer.2021.02.011
M3 - SCORING: Review article
C2 - 33631297
VL - 84
SP - 129
EP - 143
JO - SEMIN CANCER BIOL
JF - SEMIN CANCER BIOL
SN - 1044-579X
ER -
