Arterial pressure suffices to increase liver stiffness

Felix Piecha; Teresa Peccerella; Tom Bruckner; Helmut-Karl Seitz; Vanessa Rausch; Sebastian Mueller

doi:10.1152/ajpgi.00399.2015

Arterial pressure suffices to increase liver stiffness

Standard

Arterial pressure suffices to increase liver stiffness. / Piecha, Felix; Peccerella, Teresa; Bruckner, Tom; Seitz, Helmut-Karl; Rausch, Vanessa; Mueller, Sebastian.

In: AM J PHYSIOL-GASTR L, Vol. 311, No. 5, 01.11.2016, p. G945-G953.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Piecha, F, Peccerella, T, Bruckner, T, Seitz, H-K, Rausch, V & Mueller, S 2016, 'Arterial pressure suffices to increase liver stiffness', AM J PHYSIOL-GASTR L, vol. 311, no. 5, pp. G945-G953. https://doi.org/10.1152/ajpgi.00399.2015

APA

Piecha, F., Peccerella, T., Bruckner, T., Seitz, H-K., Rausch, V., & Mueller, S. (2016). Arterial pressure suffices to increase liver stiffness. AM J PHYSIOL-GASTR L, 311(5), G945-G953. https://doi.org/10.1152/ajpgi.00399.2015

Vancouver

Piecha F, Peccerella T, Bruckner T, Seitz H-K, Rausch V, Mueller S. Arterial pressure suffices to increase liver stiffness. AM J PHYSIOL-GASTR L. 2016 Nov 1;311(5):G945-G953. https://doi.org/10.1152/ajpgi.00399.2015

Bibtex

@article{afb09faa9e3b49828279323d21243e37,

title = "Arterial pressure suffices to increase liver stiffness",

abstract = "Noninvasive measurement of liver stiffness (LS) has been established to screen for liver fibrosis. Since LS is also elevated in response to pressure-related conditions such as liver congestion, this study was undertaken to learn more about the role of arterial pressure on LS. LS was measured by transient elastography (μFibroscan platform, Echosens, Paris, France) during single intravenous injections of catecholamines in anesthetized rats with and without thioacetamide (TAA)-induced fibrosis. The effect of vasodilating glycerol trinitrate (GTN) on LS was also studied. Pressures in the abdominal aorta and caval and portal veins were measured in real time with the PowerLab device (AD Instruments, Dunedin, New Zealand). Baseline LS values in all rats (3.8 ± 0.5 kPa, n = 25) did not significantly differ from those in humans. Epinephrine and norepinephrine drastically increased mean arterial pressure (MAP) from 82 to 173 and 156 mmHg. Concomitantly, LS almost doubled from 4 to 8 kPa, while central venous pressure remained unchanged. Likewise, portal pressure only showed a slight and delayed increase. In the TAA-induced fibrosis model, LS increased from 9.5 ± 1.0 to 25.6 ± 14.7 kPa upon epinephrine injection and could efficiently be decreased by GTN. We finally show a direct association in humans in a physiological setting of elevated cardiac output and MAP. During continuous spinning at 200 W, MAP increased from 84 ± 8 to 99 ± 11 mmHg while LS significantly increased from 4.4 ± 1.8 to 6.7 ± 2.1 kPa. In conclusion, our data show that arterial pressure suffices to increase LS. Moreover, lowering MAP efficiently decreases LS in fibrotic livers that are predominantly supplied by arterial blood.",

keywords = "Animals, Aorta, Abdominal, Arterial Pressure, Catecholamines, Elasticity Imaging Techniques, Epinephrine, Liver, Liver Cirrhosis, Male, Norepinephrine, Rats, Rats, Wistar, Journal Article",

author = "Felix Piecha and Teresa Peccerella and Tom Bruckner and Helmut-Karl Seitz and Vanessa Rausch and Sebastian Mueller",

note = "Copyright {\textcopyright} 2016 the American Physiological Society.",

year = "2016",

month = nov,

day = "1",

doi = "10.1152/ajpgi.00399.2015",

language = "English",

volume = "311",

pages = "G945--G953",

journal = "AM J PHYSIOL-GASTR L",

issn = "0193-1857",

publisher = "American Physiological Society",

number = "5",

}

RIS

TY - JOUR

T1 - Arterial pressure suffices to increase liver stiffness

AU - Piecha, Felix

AU - Peccerella, Teresa

AU - Bruckner, Tom

AU - Seitz, Helmut-Karl

AU - Rausch, Vanessa

AU - Mueller, Sebastian

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Noninvasive measurement of liver stiffness (LS) has been established to screen for liver fibrosis. Since LS is also elevated in response to pressure-related conditions such as liver congestion, this study was undertaken to learn more about the role of arterial pressure on LS. LS was measured by transient elastography (μFibroscan platform, Echosens, Paris, France) during single intravenous injections of catecholamines in anesthetized rats with and without thioacetamide (TAA)-induced fibrosis. The effect of vasodilating glycerol trinitrate (GTN) on LS was also studied. Pressures in the abdominal aorta and caval and portal veins were measured in real time with the PowerLab device (AD Instruments, Dunedin, New Zealand). Baseline LS values in all rats (3.8 ± 0.5 kPa, n = 25) did not significantly differ from those in humans. Epinephrine and norepinephrine drastically increased mean arterial pressure (MAP) from 82 to 173 and 156 mmHg. Concomitantly, LS almost doubled from 4 to 8 kPa, while central venous pressure remained unchanged. Likewise, portal pressure only showed a slight and delayed increase. In the TAA-induced fibrosis model, LS increased from 9.5 ± 1.0 to 25.6 ± 14.7 kPa upon epinephrine injection and could efficiently be decreased by GTN. We finally show a direct association in humans in a physiological setting of elevated cardiac output and MAP. During continuous spinning at 200 W, MAP increased from 84 ± 8 to 99 ± 11 mmHg while LS significantly increased from 4.4 ± 1.8 to 6.7 ± 2.1 kPa. In conclusion, our data show that arterial pressure suffices to increase LS. Moreover, lowering MAP efficiently decreases LS in fibrotic livers that are predominantly supplied by arterial blood.

AB - Noninvasive measurement of liver stiffness (LS) has been established to screen for liver fibrosis. Since LS is also elevated in response to pressure-related conditions such as liver congestion, this study was undertaken to learn more about the role of arterial pressure on LS. LS was measured by transient elastography (μFibroscan platform, Echosens, Paris, France) during single intravenous injections of catecholamines in anesthetized rats with and without thioacetamide (TAA)-induced fibrosis. The effect of vasodilating glycerol trinitrate (GTN) on LS was also studied. Pressures in the abdominal aorta and caval and portal veins were measured in real time with the PowerLab device (AD Instruments, Dunedin, New Zealand). Baseline LS values in all rats (3.8 ± 0.5 kPa, n = 25) did not significantly differ from those in humans. Epinephrine and norepinephrine drastically increased mean arterial pressure (MAP) from 82 to 173 and 156 mmHg. Concomitantly, LS almost doubled from 4 to 8 kPa, while central venous pressure remained unchanged. Likewise, portal pressure only showed a slight and delayed increase. In the TAA-induced fibrosis model, LS increased from 9.5 ± 1.0 to 25.6 ± 14.7 kPa upon epinephrine injection and could efficiently be decreased by GTN. We finally show a direct association in humans in a physiological setting of elevated cardiac output and MAP. During continuous spinning at 200 W, MAP increased from 84 ± 8 to 99 ± 11 mmHg while LS significantly increased from 4.4 ± 1.8 to 6.7 ± 2.1 kPa. In conclusion, our data show that arterial pressure suffices to increase LS. Moreover, lowering MAP efficiently decreases LS in fibrotic livers that are predominantly supplied by arterial blood.

KW - Animals

KW - Aorta, Abdominal

KW - Arterial Pressure

KW - Catecholamines

KW - Elasticity Imaging Techniques

KW - Epinephrine

KW - Liver

KW - Liver Cirrhosis

KW - Male

KW - Norepinephrine

KW - Rats

KW - Rats, Wistar

KW - Journal Article

U2 - 10.1152/ajpgi.00399.2015

DO - 10.1152/ajpgi.00399.2015

M3 - SCORING: Journal article

C2 - 27288426

VL - 311

SP - G945-G953

JO - AM J PHYSIOL-GASTR L

JF - AM J PHYSIOL-GASTR L

SN - 0193-1857

IS - 5

ER -