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Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice

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Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice. / Prange-Kiel, Janine; Dudzinski, Danuta; Pröls, Felicitas; Glatzel, Markus; Matschke, Jakob; Rune, Gabriele M.

In: NEURAL PLAST, 05.2016, p. 9802086.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Prange-Kiel, J, Dudzinski, D, Pröls, F, Glatzel, M, Matschke, J & Rune, GM 2016, 'Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice', NEURAL PLAST, pp. 9802086. https://doi.org/10.1155/2016/9802086

APA

Prange-Kiel, J., Dudzinski, D., Pröls, F., Glatzel, M., Matschke, J., & Rune, G. M. (2016). Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice. NEURAL PLAST, 9802086. https://doi.org/10.1155/2016/9802086

Vancouver

Prange-Kiel J, Dudzinski D, Pröls F, Glatzel M, Matschke J, Rune GM. Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice. NEURAL PLAST. 2016 May;9802086. https://doi.org/10.1155/2016/9802086

Bibtex

@article{b98acd4dfe4b405eb7244baa30f7f1da,
title = "Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice",
abstract = "Numerous studies show that 17β-estradiol (E2) protects against Alzheimer's disease (AD) induced neurodegeneration. The E2-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is known about the expression of hippocampal aromatase in AD. To better understand the role of hippocampal aromatase in AD, we studied its expression in postmortem material from patients with AD and in a mouse model for AD (5xFAD mice). In human hippocampi, aromatase-immunoreactivity was observed in the vast majority of principal neurons and signal quantification revealed higher expression of aromatase protein in AD patients compared to age- and sex-matched controls. The tissue-specific first exons of aromatase I.f, PII, I.3, and I.6 were detected in hippocampi of controls and AD patients by RT-PCR. In contrast, 3-month-old, female 5xFAD mice showed lower expression of aromatase mRNA and protein (measured by qRT-PCR and semiquantitative immunohistochemistry) than WT controls; no such differences were observed in male mice. Our findings stress the importance of hippocampal aromatase expression in neurodegenerative diseases.",
keywords = "Journal Article, Aromatase, Hippocampus, AD Patients",
author = "Janine Prange-Kiel and Danuta Dudzinski and Felicitas Pr{\"o}ls and Markus Glatzel and Jakob Matschke and Rune, {Gabriele M}",
year = "2016",
month = may,
doi = "10.1155/2016/9802086",
language = "English",
pages = "9802086",
journal = "NEURAL PLAST",
issn = "2090-5904",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice

AU - Prange-Kiel, Janine

AU - Dudzinski, Danuta

AU - Pröls, Felicitas

AU - Glatzel, Markus

AU - Matschke, Jakob

AU - Rune, Gabriele M

PY - 2016/5

Y1 - 2016/5

N2 - Numerous studies show that 17β-estradiol (E2) protects against Alzheimer's disease (AD) induced neurodegeneration. The E2-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is known about the expression of hippocampal aromatase in AD. To better understand the role of hippocampal aromatase in AD, we studied its expression in postmortem material from patients with AD and in a mouse model for AD (5xFAD mice). In human hippocampi, aromatase-immunoreactivity was observed in the vast majority of principal neurons and signal quantification revealed higher expression of aromatase protein in AD patients compared to age- and sex-matched controls. The tissue-specific first exons of aromatase I.f, PII, I.3, and I.6 were detected in hippocampi of controls and AD patients by RT-PCR. In contrast, 3-month-old, female 5xFAD mice showed lower expression of aromatase mRNA and protein (measured by qRT-PCR and semiquantitative immunohistochemistry) than WT controls; no such differences were observed in male mice. Our findings stress the importance of hippocampal aromatase expression in neurodegenerative diseases.

AB - Numerous studies show that 17β-estradiol (E2) protects against Alzheimer's disease (AD) induced neurodegeneration. The E2-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is known about the expression of hippocampal aromatase in AD. To better understand the role of hippocampal aromatase in AD, we studied its expression in postmortem material from patients with AD and in a mouse model for AD (5xFAD mice). In human hippocampi, aromatase-immunoreactivity was observed in the vast majority of principal neurons and signal quantification revealed higher expression of aromatase protein in AD patients compared to age- and sex-matched controls. The tissue-specific first exons of aromatase I.f, PII, I.3, and I.6 were detected in hippocampi of controls and AD patients by RT-PCR. In contrast, 3-month-old, female 5xFAD mice showed lower expression of aromatase mRNA and protein (measured by qRT-PCR and semiquantitative immunohistochemistry) than WT controls; no such differences were observed in male mice. Our findings stress the importance of hippocampal aromatase expression in neurodegenerative diseases.

KW - Journal Article

KW - Aromatase

KW - Hippocampus

KW - AD Patients

U2 - 10.1155/2016/9802086

DO - 10.1155/2016/9802086

M3 - SCORING: Journal article

C2 - 27298742

SP - 9802086

JO - NEURAL PLAST

JF - NEURAL PLAST

SN - 2090-5904

ER -