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Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications

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Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications. / Grosse, Gerrit M; Schwedhelm, Edzard; Worthmann, Hans; Choe, Chi-Un.

In: INT J MOL SCI, Vol. 21, No. 5, 05.03.2020.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Grosse, GM, Schwedhelm, E, Worthmann, H & Choe, C-U 2020, 'Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications', INT J MOL SCI, vol. 21, no. 5. https://doi.org/10.3390/ijms21051798

APA

Grosse, G. M., Schwedhelm, E., Worthmann, H., & Choe, C-U. (2020). Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications. INT J MOL SCI, 21(5). https://doi.org/10.3390/ijms21051798

Vancouver

Grosse GM, Schwedhelm E, Worthmann H, Choe C-U. Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications. INT J MOL SCI. 2020 Mar 5;21(5). https://doi.org/10.3390/ijms21051798

Bibtex

@article{cdfa9432b32048b9965788b8a958bfa9,
title = "Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications",
abstract = "The amino acid L-arginine serves as substrate for the nitric oxide synthase which is crucial in vascular function and disease. Derivatives of arginine, such as asymmetric (ADMA) and symmetric dimethylarginine (SDMA), are regarded as markers of endothelial dysfunction and have been implicated in vascular disorders. While there is a variety of studies consolidating ADMA as biomarker of cerebrovascular risk, morbidity and mortality, SDMA is currently emerging as an interesting metabolite with distinct characteristics in ischemic stroke. In contrast to dimethylarginines, homoarginine is inversely associated with adverse events and mortality in cerebrovascular diseases and might constitute a modifiable protective risk factor. This review aims to provide an overview of the current evidence for the pathophysiological role of arginine derivatives in cerebrovascular ischemic diseases. We discuss the complex mechanisms of arginine metabolism in health and disease and its potential clinical implications in diverse aspects of ischemic stroke.",
author = "Grosse, {Gerrit M} and Edzard Schwedhelm and Hans Worthmann and Chi-Un Choe",
year = "2020",
month = mar,
day = "5",
doi = "10.3390/ijms21051798",
language = "English",
volume = "21",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "5",

}

RIS

TY - JOUR

T1 - Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications

AU - Grosse, Gerrit M

AU - Schwedhelm, Edzard

AU - Worthmann, Hans

AU - Choe, Chi-Un

PY - 2020/3/5

Y1 - 2020/3/5

N2 - The amino acid L-arginine serves as substrate for the nitric oxide synthase which is crucial in vascular function and disease. Derivatives of arginine, such as asymmetric (ADMA) and symmetric dimethylarginine (SDMA), are regarded as markers of endothelial dysfunction and have been implicated in vascular disorders. While there is a variety of studies consolidating ADMA as biomarker of cerebrovascular risk, morbidity and mortality, SDMA is currently emerging as an interesting metabolite with distinct characteristics in ischemic stroke. In contrast to dimethylarginines, homoarginine is inversely associated with adverse events and mortality in cerebrovascular diseases and might constitute a modifiable protective risk factor. This review aims to provide an overview of the current evidence for the pathophysiological role of arginine derivatives in cerebrovascular ischemic diseases. We discuss the complex mechanisms of arginine metabolism in health and disease and its potential clinical implications in diverse aspects of ischemic stroke.

AB - The amino acid L-arginine serves as substrate for the nitric oxide synthase which is crucial in vascular function and disease. Derivatives of arginine, such as asymmetric (ADMA) and symmetric dimethylarginine (SDMA), are regarded as markers of endothelial dysfunction and have been implicated in vascular disorders. While there is a variety of studies consolidating ADMA as biomarker of cerebrovascular risk, morbidity and mortality, SDMA is currently emerging as an interesting metabolite with distinct characteristics in ischemic stroke. In contrast to dimethylarginines, homoarginine is inversely associated with adverse events and mortality in cerebrovascular diseases and might constitute a modifiable protective risk factor. This review aims to provide an overview of the current evidence for the pathophysiological role of arginine derivatives in cerebrovascular ischemic diseases. We discuss the complex mechanisms of arginine metabolism in health and disease and its potential clinical implications in diverse aspects of ischemic stroke.

U2 - 10.3390/ijms21051798

DO - 10.3390/ijms21051798

M3 - SCORING: Review article

C2 - 32150996

VL - 21

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 5

ER -