Are there time-dependent differences in diffusion and perfusion within the first 6 hours after stroke onset?
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Are there time-dependent differences in diffusion and perfusion within the first 6 hours after stroke onset? / Fiehler, Jens; Kucinski, Thomas; Knudsen, Karina; Rosenkranz, Michael; Thomalla, Götz; Weiller, Cornelius; Röther, Joachim; Zeumer, Hermann.
In: STROKE, Vol. 35, No. 9, 9, 2004, p. 2099-2104.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Are there time-dependent differences in diffusion and perfusion within the first 6 hours after stroke onset?
AU - Fiehler, Jens
AU - Kucinski, Thomas
AU - Knudsen, Karina
AU - Rosenkranz, Michael
AU - Thomalla, Götz
AU - Weiller, Cornelius
AU - Röther, Joachim
AU - Zeumer, Hermann
PY - 2004
Y1 - 2004
N2 - BACKGROUND AND PURPOSE: Stroke heterogeneity in computed tomography-based studies has been attributed as main cause for missing efficacy of intravenous tissue plasminogen activator (tPA) therapy within 3 to 6 hours. We investigated early time-dependent differences in acute stroke pathophysiology by multiparametric magnetic resonance imaging (MRI). METHODS: Stroke MRI of 112 acute ischemic stroke patients within 8 seconds. A subsample analysis was performed for occlusions of the middle carotid artery (MCA) trunk (n=36) and MCA branches (n=30), and for all patients treated by intravenous tPA (n=70). RESULTS: ADC and TTP lesion volumes were not different within 2 seconds, and infarct volume (days 5 to 8) between the 2 groups. There was a greater proportion of ADC
AB - BACKGROUND AND PURPOSE: Stroke heterogeneity in computed tomography-based studies has been attributed as main cause for missing efficacy of intravenous tissue plasminogen activator (tPA) therapy within 3 to 6 hours. We investigated early time-dependent differences in acute stroke pathophysiology by multiparametric magnetic resonance imaging (MRI). METHODS: Stroke MRI of 112 acute ischemic stroke patients within 8 seconds. A subsample analysis was performed for occlusions of the middle carotid artery (MCA) trunk (n=36) and MCA branches (n=30), and for all patients treated by intravenous tPA (n=70). RESULTS: ADC and TTP lesion volumes were not different within 2 seconds, and infarct volume (days 5 to 8) between the 2 groups. There was a greater proportion of ADC
M3 - SCORING: Zeitschriftenaufsatz
VL - 35
SP - 2099
EP - 2104
JO - STROKE
JF - STROKE
SN - 0039-2499
IS - 9
M1 - 9
ER -