Are there time-dependent differences in diffusion and perfusion within the first 6 hours after stroke onset?

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Are there time-dependent differences in diffusion and perfusion within the first 6 hours after stroke onset? / Fiehler, Jens; Kucinski, Thomas; Knudsen, Karina; Rosenkranz, Michael; Thomalla, Götz; Weiller, Cornelius; Röther, Joachim; Zeumer, Hermann.

In: STROKE, Vol. 35, No. 9, 9, 2004, p. 2099-2104.

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@article{9d92579bc15141dda191055ea62ce60f,
title = "Are there time-dependent differences in diffusion and perfusion within the first 6 hours after stroke onset?",
abstract = "BACKGROUND AND PURPOSE: Stroke heterogeneity in computed tomography-based studies has been attributed as main cause for missing efficacy of intravenous tissue plasminogen activator (tPA) therapy within 3 to 6 hours. We investigated early time-dependent differences in acute stroke pathophysiology by multiparametric magnetic resonance imaging (MRI). METHODS: Stroke MRI of 112 acute ischemic stroke patients within 8 seconds. A subsample analysis was performed for occlusions of the middle carotid artery (MCA) trunk (n=36) and MCA branches (n=30), and for all patients treated by intravenous tPA (n=70). RESULTS: ADC and TTP lesion volumes were not different within 2 seconds, and infarct volume (days 5 to 8) between the 2 groups. There was a greater proportion of ADC",
author = "Jens Fiehler and Thomas Kucinski and Karina Knudsen and Michael Rosenkranz and G{\"o}tz Thomalla and Cornelius Weiller and Joachim R{\"o}ther and Hermann Zeumer",
year = "2004",
language = "Deutsch",
volume = "35",
pages = "2099--2104",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

RIS

TY - JOUR

T1 - Are there time-dependent differences in diffusion and perfusion within the first 6 hours after stroke onset?

AU - Fiehler, Jens

AU - Kucinski, Thomas

AU - Knudsen, Karina

AU - Rosenkranz, Michael

AU - Thomalla, Götz

AU - Weiller, Cornelius

AU - Röther, Joachim

AU - Zeumer, Hermann

PY - 2004

Y1 - 2004

N2 - BACKGROUND AND PURPOSE: Stroke heterogeneity in computed tomography-based studies has been attributed as main cause for missing efficacy of intravenous tissue plasminogen activator (tPA) therapy within 3 to 6 hours. We investigated early time-dependent differences in acute stroke pathophysiology by multiparametric magnetic resonance imaging (MRI). METHODS: Stroke MRI of 112 acute ischemic stroke patients within 8 seconds. A subsample analysis was performed for occlusions of the middle carotid artery (MCA) trunk (n=36) and MCA branches (n=30), and for all patients treated by intravenous tPA (n=70). RESULTS: ADC and TTP lesion volumes were not different within 2 seconds, and infarct volume (days 5 to 8) between the 2 groups. There was a greater proportion of ADC

AB - BACKGROUND AND PURPOSE: Stroke heterogeneity in computed tomography-based studies has been attributed as main cause for missing efficacy of intravenous tissue plasminogen activator (tPA) therapy within 3 to 6 hours. We investigated early time-dependent differences in acute stroke pathophysiology by multiparametric magnetic resonance imaging (MRI). METHODS: Stroke MRI of 112 acute ischemic stroke patients within 8 seconds. A subsample analysis was performed for occlusions of the middle carotid artery (MCA) trunk (n=36) and MCA branches (n=30), and for all patients treated by intravenous tPA (n=70). RESULTS: ADC and TTP lesion volumes were not different within 2 seconds, and infarct volume (days 5 to 8) between the 2 groups. There was a greater proportion of ADC

M3 - SCORING: Zeitschriftenaufsatz

VL - 35

SP - 2099

EP - 2104

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 9

M1 - 9

ER -