Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.

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Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma. / Bethge, Anja; Schumacher, Udo; Wree, Andreas; Wedemann, Gero.

In: PLOS ONE, Vol. 7, No. 4, 4, 2012, p. 35689.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

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@article{84c701a937f249eda5f89c379769bd45,
title = "Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.",
abstract = "Metastasis formation remains an enigmatic process and one of the main questions recently asked is whether metastases are able to generate further metastases. Different models have been proposed to answer this question; however, their clinical significance remains unclear. Therefore a computer model was developed that permits comparison of the different models quantitatively with clinical data and that additionally predicts the outcome of treatment interventions.",
keywords = "Humans, Cell Count, *Computer Simulation, Carcinoma, Hepatocellular/mortality/*pathology, Liver Neoplasms/mortality/*pathology, *Neoplasm Metastasis, Neoplastic Stem Cells/cytology, Humans, Cell Count, *Computer Simulation, Carcinoma, Hepatocellular/mortality/*pathology, Liver Neoplasms/mortality/*pathology, *Neoplasm Metastasis, Neoplastic Stem Cells/cytology",
author = "Anja Bethge and Udo Schumacher and Andreas Wree and Gero Wedemann",
year = "2012",
doi = "10.1371/journal.pone.0035689",
language = "English",
volume = "7",
pages = "35689",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.

AU - Bethge, Anja

AU - Schumacher, Udo

AU - Wree, Andreas

AU - Wedemann, Gero

PY - 2012

Y1 - 2012

N2 - Metastasis formation remains an enigmatic process and one of the main questions recently asked is whether metastases are able to generate further metastases. Different models have been proposed to answer this question; however, their clinical significance remains unclear. Therefore a computer model was developed that permits comparison of the different models quantitatively with clinical data and that additionally predicts the outcome of treatment interventions.

AB - Metastasis formation remains an enigmatic process and one of the main questions recently asked is whether metastases are able to generate further metastases. Different models have been proposed to answer this question; however, their clinical significance remains unclear. Therefore a computer model was developed that permits comparison of the different models quantitatively with clinical data and that additionally predicts the outcome of treatment interventions.

KW - Humans

KW - Cell Count

KW - Computer Simulation

KW - Carcinoma, Hepatocellular/mortality/pathology

KW - Liver Neoplasms/mortality/pathology

KW - Neoplasm Metastasis

KW - Neoplastic Stem Cells/cytology

KW - Humans

KW - Cell Count

KW - Computer Simulation

KW - Carcinoma, Hepatocellular/mortality/pathology

KW - Liver Neoplasms/mortality/pathology

KW - Neoplasm Metastasis

KW - Neoplastic Stem Cells/cytology

U2 - 10.1371/journal.pone.0035689

DO - 10.1371/journal.pone.0035689

M3 - SCORING: Journal article

VL - 7

SP - 35689

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 4

M1 - 4

ER -