Research ExplorerPublicationsApplications of Metals for Bone Regeneration

Applications of Metals for Bone Regeneration

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Applications of Metals for Bone Regeneration. / Glenske, Kristina; Donkiewicz, Phil; Köwitsch, Alexander; Milosevic-Oljaca, Nada; Rider, Patrick; Rofall, Sven; Franke, Jörg; Jung, Ole; Smeets, Ralf; Schnettler, Reinhard; Wenisch, Sabine; Barbeck, Mike.

In: INT J MOL SCI, Vol. 19, No. 3, 12.03.2018.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Glenske, K, Donkiewicz, P, Köwitsch, A, Milosevic-Oljaca, N, Rider, P, Rofall, S, Franke, J, Jung, O, Smeets, R, Schnettler, R, Wenisch, S & Barbeck, M 2018, 'Applications of Metals for Bone Regeneration', INT J MOL SCI, vol. 19, no. 3. https://doi.org/10.3390/ijms19030826

APA

Glenske, K., Donkiewicz, P., Köwitsch, A., Milosevic-Oljaca, N., Rider, P., Rofall, S., Franke, J., Jung, O., Smeets, R., Schnettler, R., Wenisch, S., & Barbeck, M. (2018). Applications of Metals for Bone Regeneration. INT J MOL SCI, 19(3). https://doi.org/10.3390/ijms19030826

Vancouver

Glenske K, Donkiewicz P, Köwitsch A, Milosevic-Oljaca N, Rider P, Rofall S et al. Applications of Metals for Bone Regeneration. INT J MOL SCI. 2018 Mar 12;19(3). https://doi.org/10.3390/ijms19030826

Bibtex

@article{c7b2af4f522d46e6a4ca654e1b978cf7,
title = "Applications of Metals for Bone Regeneration",
abstract = "The regeneration of bone tissue is the main purpose of most therapies in dental medicine. For bone regeneration, calcium phosphate (CaP)-based substitute materials based on natural (allo- and xenografts) and synthetic origins (alloplastic materials) are applied for guiding the regeneration processes. The optimal bone substitute has to act as a substrate for bone ingrowth into a defect, as well as resorb in the time frame needed for complete regeneration up to the condition of restitution ad integrum. In this context, the modes of action of CaP-based substitute materials have been frequently investigated, where it has been shown that such materials strongly influence regenerative processes such as osteoblast growth or differentiation and also osteoclastic resorption due to different physicochemical properties of the materials. However, the material characteristics needed for the required ratio between new bone tissue formation and material degradation has not been found, until now. The addition of different substances such as collagen or growth factors and also of different cell types has already been tested but did not allow for sufficient or prompt application. Moreover, metals or metal ions are used differently as a basis or as supplement for different materials in the field of bone regeneration. Moreover, it has already been shown that different metal ions are integral components of bone tissue, playing functional roles in the physiological cellular environment as well as in the course of bone healing. The present review focuses on frequently used metals as integral parts of materials designed for bone regeneration, with the aim to provide an overview of currently existing knowledge about the effects of metals in the field of bone regeneration.",
keywords = "Journal Article, Review",
author = "Kristina Glenske and Phil Donkiewicz and Alexander K{\"o}witsch and Nada Milosevic-Oljaca and Patrick Rider and Sven Rofall and J{\"o}rg Franke and Ole Jung and Ralf Smeets and Reinhard Schnettler and Sabine Wenisch and Mike Barbeck",
year = "2018",
month = mar,
day = "12",
doi = "10.3390/ijms19030826",
language = "English",
volume = "19",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

RIS

TY - JOUR

T1 - Applications of Metals for Bone Regeneration

AU - Glenske, Kristina

AU - Donkiewicz, Phil

AU - Köwitsch, Alexander

AU - Milosevic-Oljaca, Nada

AU - Rider, Patrick

AU - Rofall, Sven

AU - Franke, Jörg

AU - Jung, Ole

AU - Smeets, Ralf

AU - Schnettler, Reinhard

AU - Wenisch, Sabine

AU - Barbeck, Mike

PY - 2018/3/12

Y1 - 2018/3/12

N2 - The regeneration of bone tissue is the main purpose of most therapies in dental medicine. For bone regeneration, calcium phosphate (CaP)-based substitute materials based on natural (allo- and xenografts) and synthetic origins (alloplastic materials) are applied for guiding the regeneration processes. The optimal bone substitute has to act as a substrate for bone ingrowth into a defect, as well as resorb in the time frame needed for complete regeneration up to the condition of restitution ad integrum. In this context, the modes of action of CaP-based substitute materials have been frequently investigated, where it has been shown that such materials strongly influence regenerative processes such as osteoblast growth or differentiation and also osteoclastic resorption due to different physicochemical properties of the materials. However, the material characteristics needed for the required ratio between new bone tissue formation and material degradation has not been found, until now. The addition of different substances such as collagen or growth factors and also of different cell types has already been tested but did not allow for sufficient or prompt application. Moreover, metals or metal ions are used differently as a basis or as supplement for different materials in the field of bone regeneration. Moreover, it has already been shown that different metal ions are integral components of bone tissue, playing functional roles in the physiological cellular environment as well as in the course of bone healing. The present review focuses on frequently used metals as integral parts of materials designed for bone regeneration, with the aim to provide an overview of currently existing knowledge about the effects of metals in the field of bone regeneration.

AB - The regeneration of bone tissue is the main purpose of most therapies in dental medicine. For bone regeneration, calcium phosphate (CaP)-based substitute materials based on natural (allo- and xenografts) and synthetic origins (alloplastic materials) are applied for guiding the regeneration processes. The optimal bone substitute has to act as a substrate for bone ingrowth into a defect, as well as resorb in the time frame needed for complete regeneration up to the condition of restitution ad integrum. In this context, the modes of action of CaP-based substitute materials have been frequently investigated, where it has been shown that such materials strongly influence regenerative processes such as osteoblast growth or differentiation and also osteoclastic resorption due to different physicochemical properties of the materials. However, the material characteristics needed for the required ratio between new bone tissue formation and material degradation has not been found, until now. The addition of different substances such as collagen or growth factors and also of different cell types has already been tested but did not allow for sufficient or prompt application. Moreover, metals or metal ions are used differently as a basis or as supplement for different materials in the field of bone regeneration. Moreover, it has already been shown that different metal ions are integral components of bone tissue, playing functional roles in the physiological cellular environment as well as in the course of bone healing. The present review focuses on frequently used metals as integral parts of materials designed for bone regeneration, with the aim to provide an overview of currently existing knowledge about the effects of metals in the field of bone regeneration.

KW - Journal Article

KW - Review

U2 - 10.3390/ijms19030826

DO - 10.3390/ijms19030826

M3 - SCORING: Review article

C2 - 29534546

VL - 19

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 3

ER -