Application of the RIMARC algorithm to a large data set of action potentials and clinical parameters for risk prediction of atrial fibrillation
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Application of the RIMARC algorithm to a large data set of action potentials and clinical parameters for risk prediction of atrial fibrillation. / Ravens, Ursula; Katircioglu-Öztürk, Deniz; Wettwer, Erich; Christ, Torsten; Dobrev, Dobromir; Voigt, Niels; Poulet, Claire; Loose, Simone; Simon, Jana; Stein, Agnes; Matschke, Klaus; Knaut, Michael; Oto, Emre; Oto, Ali; Güvenir, H Altay.
In: MED BIOL ENG COMPUT, Vol. 53, No. 3, 03.2015, p. 263-73.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Application of the RIMARC algorithm to a large data set of action potentials and clinical parameters for risk prediction of atrial fibrillation
AU - Ravens, Ursula
AU - Katircioglu-Öztürk, Deniz
AU - Wettwer, Erich
AU - Christ, Torsten
AU - Dobrev, Dobromir
AU - Voigt, Niels
AU - Poulet, Claire
AU - Loose, Simone
AU - Simon, Jana
AU - Stein, Agnes
AU - Matschke, Klaus
AU - Knaut, Michael
AU - Oto, Emre
AU - Oto, Ali
AU - Güvenir, H Altay
PY - 2015/3
Y1 - 2015/3
N2 - Ex vivo recorded action potentials (APs) in human right atrial tissue from patients in sinus rhythm (SR) or atrial fibrillation (AF) display a characteristic spike-and-dome or triangular shape, respectively, but variability is huge within each rhythm group. The aim of our study was to apply the machine-learning algorithm ranking instances by maximizing the area under the ROC curve (RIMARC) to a large data set of 480 APs combined with retrospectively collected general clinical parameters and to test whether the rules learned by the RIMARC algorithm can be used for accurately classifying the preoperative rhythm status. APs were included from 221 SR and 158 AF patients. During a learning phase, the RIMARC algorithm established a ranking order of 62 features by predictive value for SR or AF. The model was then challenged with an additional test set of features from 28 patients in whom rhythm status was blinded. The accuracy of the risk prediction for AF by the model was very good (0.93) when all features were used. Without the seven AP features, accuracy still reached 0.71. In conclusion, we have shown that training the machine-learning algorithm RIMARC with an experimental and clinical data set allows predicting a classification in a test data set with high accuracy. In a clinical setting, this approach may prove useful for finding hypothesis-generating associations between different parameters.
AB - Ex vivo recorded action potentials (APs) in human right atrial tissue from patients in sinus rhythm (SR) or atrial fibrillation (AF) display a characteristic spike-and-dome or triangular shape, respectively, but variability is huge within each rhythm group. The aim of our study was to apply the machine-learning algorithm ranking instances by maximizing the area under the ROC curve (RIMARC) to a large data set of 480 APs combined with retrospectively collected general clinical parameters and to test whether the rules learned by the RIMARC algorithm can be used for accurately classifying the preoperative rhythm status. APs were included from 221 SR and 158 AF patients. During a learning phase, the RIMARC algorithm established a ranking order of 62 features by predictive value for SR or AF. The model was then challenged with an additional test set of features from 28 patients in whom rhythm status was blinded. The accuracy of the risk prediction for AF by the model was very good (0.93) when all features were used. Without the seven AP features, accuracy still reached 0.71. In conclusion, we have shown that training the machine-learning algorithm RIMARC with an experimental and clinical data set allows predicting a classification in a test data set with high accuracy. In a clinical setting, this approach may prove useful for finding hypothesis-generating associations between different parameters.
U2 - 10.1007/s11517-014-1232-0
DO - 10.1007/s11517-014-1232-0
M3 - SCORING: Journal article
C2 - 25466224
VL - 53
SP - 263
EP - 273
JO - MED BIOL ENG COMPUT
JF - MED BIOL ENG COMPUT
SN - 0140-0118
IS - 3
ER -