Apolipoprotein E-ε4 deficiency and cognitive function in hepatitis C virus-infected patients
Standard
Apolipoprotein E-ε4 deficiency and cognitive function in hepatitis C virus-infected patients. / Wozniak, M A; Lugo Iparraguirre, L M; Dirks, M; Deb-Chatterji, Milani; Pflugrad, H; Goldbecker, A; Tryc, A B; Worthmann, H; Gess, M; Crossey, M M E; Forton, D M; Taylor-Robinson, S D; Itzhaki, R F; Weissenborn, K.
In: J VIRAL HEPATITIS, Vol. 23, No. 1, 01.2016, p. 39-46.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Apolipoprotein E-ε4 deficiency and cognitive function in hepatitis C virus-infected patients
AU - Wozniak, M A
AU - Lugo Iparraguirre, L M
AU - Dirks, M
AU - Deb-Chatterji, Milani
AU - Pflugrad, H
AU - Goldbecker, A
AU - Tryc, A B
AU - Worthmann, H
AU - Gess, M
AU - Crossey, M M E
AU - Forton, D M
AU - Taylor-Robinson, S D
AU - Itzhaki, R F
AU - Weissenborn, K
N1 - © 2015 John Wiley & Sons Ltd.
PY - 2016/1
Y1 - 2016/1
N2 - Hepatitis C virus (HCV) causes not only liver damage in certain patients but can also lead to neuropsychiatric symptoms. Previous studies have shown that the type 4 allele of the gene for apolipoprotein E (APOE) is strongly protective against HCV-induced damage in liver. In this study, we have investigated the possibility that APOE genotype is involved in the action of HCV in brain. One hundred HCV-infected patients with mild liver disease underwent a neurological examination and a comprehensive psychometric testing of attention and memory function. In addition, patients completed questionnaires for the assessment of fatigue, health-related quality of life and mood disturbances. Apolipoprotein E gene genotyping was carried out on saliva using buccal swabs. The APOE-ε4 allele frequency was significantly lower in patients with an impairment of working memory, compared to those with a normal working memory test result (P = 0.003). A lower APOE-ε4 allele frequency was also observed in patients with definitely altered attention ability (P = 0.008), but here, the P-value missed the level of significance after application of the Bonferroni correction. Our data suggest that the APOE-ε4 allele is protective against attention deficit and especially against poor working memory in HCV-infected subjects with mild liver disease. Considering the role of apolipoprotein E in the life cycle of the virus, the findings shed interesting new light upon possible pathomechanisms behind the development of neuropsychiatric symptoms in hepatitis C infection.
AB - Hepatitis C virus (HCV) causes not only liver damage in certain patients but can also lead to neuropsychiatric symptoms. Previous studies have shown that the type 4 allele of the gene for apolipoprotein E (APOE) is strongly protective against HCV-induced damage in liver. In this study, we have investigated the possibility that APOE genotype is involved in the action of HCV in brain. One hundred HCV-infected patients with mild liver disease underwent a neurological examination and a comprehensive psychometric testing of attention and memory function. In addition, patients completed questionnaires for the assessment of fatigue, health-related quality of life and mood disturbances. Apolipoprotein E gene genotyping was carried out on saliva using buccal swabs. The APOE-ε4 allele frequency was significantly lower in patients with an impairment of working memory, compared to those with a normal working memory test result (P = 0.003). A lower APOE-ε4 allele frequency was also observed in patients with definitely altered attention ability (P = 0.008), but here, the P-value missed the level of significance after application of the Bonferroni correction. Our data suggest that the APOE-ε4 allele is protective against attention deficit and especially against poor working memory in HCV-infected subjects with mild liver disease. Considering the role of apolipoprotein E in the life cycle of the virus, the findings shed interesting new light upon possible pathomechanisms behind the development of neuropsychiatric symptoms in hepatitis C infection.
KW - Adult
KW - Aged
KW - Alleles
KW - Apolipoprotein E4
KW - Cognition
KW - Cognitive Dysfunction
KW - Female
KW - Gene Frequency
KW - Hepacivirus
KW - Hepatic Encephalopathy
KW - Hepatitis C, Chronic
KW - Humans
KW - Liver
KW - Male
KW - Memory, Short-Term
KW - Middle Aged
KW - Mood Disorders
KW - Neurodegenerative Diseases
KW - Neuropsychological Tests
KW - Quality of Life
KW - Surveys and Questionnaires
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1111/jvh.12443
DO - 10.1111/jvh.12443
M3 - SCORING: Journal article
C2 - 26306786
VL - 23
SP - 39
EP - 46
JO - J VIRAL HEPATITIS
JF - J VIRAL HEPATITIS
SN - 1352-0504
IS - 1
ER -
