Antigen-specific γδ T cells contribute to cytomegalovirus control after stem cell transplantation

Immo Prinz; Christian Koenecke

doi:10.1016/j.coi.2023.102303

Antigen-specific γδ T cells contribute to cytomegalovirus control after stem cell transplantation

Standard

Antigen-specific γδ T cells contribute to cytomegalovirus control after stem cell transplantation. / Prinz, Immo; Koenecke, Christian.

In: CURR OPIN IMMUNOL, Vol. 82, 06.2023, p. 102303.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Prinz, I & Koenecke, C 2023, 'Antigen-specific γδ T cells contribute to cytomegalovirus control after stem cell transplantation', CURR OPIN IMMUNOL, vol. 82, pp. 102303. https://doi.org/10.1016/j.coi.2023.102303

APA

Prinz, I., & Koenecke, C. (2023). Antigen-specific γδ T cells contribute to cytomegalovirus control after stem cell transplantation. CURR OPIN IMMUNOL, 82, 102303. https://doi.org/10.1016/j.coi.2023.102303

Vancouver

Prinz I, Koenecke C. Antigen-specific γδ T cells contribute to cytomegalovirus control after stem cell transplantation. CURR OPIN IMMUNOL. 2023 Jun;82:102303. https://doi.org/10.1016/j.coi.2023.102303

Bibtex

@article{cbc8cb1b082043cabee83c62e952e4c9,

title = "Antigen-specific γδ T cells contribute to cytomegalovirus control after stem cell transplantation",

abstract = "γδ T cells support the immunological control of viral infections, in particular during cytomegalovirus (CMV) reactivation in immunocompromised patients after allogeneic hematopoietic stem cell transplantation. It is unclear how γδ T cells sense CMV-infection and whether this involves specific T cell receptor (TCR)-ligand interaction. Here we summarize recent findings that revealed an adaptive-like anti-CMV immune response of γδ T cells, characterized by acquisition of effector functions and long-lasting clonal expansion. We propose that rather CMV-induced self-antigen than viral antigens trigger γδ TCRs during CMV reactivation. Given that the TCRs of CMV-activated γδ T cells are often cross-reactive to tumor cells, these findings pinpoint γδ T cells and their γδ TCRs as attractive multipurpose tools for antiviral and antitumor therapy.",

keywords = "Humans, Cytomegalovirus, T-Lymphocyte Subsets, Cytomegalovirus Infections/therapy, Hematopoietic Stem Cell Transplantation, Receptors, Antigen, T-Cell, Antigens, Viral, Receptors, Antigen, T-Cell, gamma-delta",

author = "Immo Prinz and Christian Koenecke",

year = "2023",

month = jun,

doi = "10.1016/j.coi.2023.102303",

language = "English",

volume = "82",

pages = "102303",

}

RIS

TY - JOUR

T1 - Antigen-specific γδ T cells contribute to cytomegalovirus control after stem cell transplantation

AU - Prinz, Immo

AU - Koenecke, Christian

PY - 2023/6

Y1 - 2023/6

N2 - γδ T cells support the immunological control of viral infections, in particular during cytomegalovirus (CMV) reactivation in immunocompromised patients after allogeneic hematopoietic stem cell transplantation. It is unclear how γδ T cells sense CMV-infection and whether this involves specific T cell receptor (TCR)-ligand interaction. Here we summarize recent findings that revealed an adaptive-like anti-CMV immune response of γδ T cells, characterized by acquisition of effector functions and long-lasting clonal expansion. We propose that rather CMV-induced self-antigen than viral antigens trigger γδ TCRs during CMV reactivation. Given that the TCRs of CMV-activated γδ T cells are often cross-reactive to tumor cells, these findings pinpoint γδ T cells and their γδ TCRs as attractive multipurpose tools for antiviral and antitumor therapy.

AB - γδ T cells support the immunological control of viral infections, in particular during cytomegalovirus (CMV) reactivation in immunocompromised patients after allogeneic hematopoietic stem cell transplantation. It is unclear how γδ T cells sense CMV-infection and whether this involves specific T cell receptor (TCR)-ligand interaction. Here we summarize recent findings that revealed an adaptive-like anti-CMV immune response of γδ T cells, characterized by acquisition of effector functions and long-lasting clonal expansion. We propose that rather CMV-induced self-antigen than viral antigens trigger γδ TCRs during CMV reactivation. Given that the TCRs of CMV-activated γδ T cells are often cross-reactive to tumor cells, these findings pinpoint γδ T cells and their γδ TCRs as attractive multipurpose tools for antiviral and antitumor therapy.

KW - Humans

KW - Cytomegalovirus

KW - T-Lymphocyte Subsets

KW - Cytomegalovirus Infections/therapy

KW - Hematopoietic Stem Cell Transplantation

KW - Receptors, Antigen, T-Cell

KW - Antigens, Viral

KW - Receptors, Antigen, T-Cell, gamma-delta

U2 - 10.1016/j.coi.2023.102303

DO - 10.1016/j.coi.2023.102303

M3 - SCORING: Review article

C2 - 36947903

VL - 82

SP - 102303

ER -