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Anthracyclines induce DNA damage response-mediated protection against severe sepsis

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Anthracyclines induce DNA damage response-mediated protection against severe sepsis. / Figueiredo, Nuno; Chora, Angelo; Raquel, Helena; Pejanovic, Nadja; Pereira, Pedro; Hartleben, Björn; Neves-Costa, Ana; Moita, Catarina; Pedroso, Dora; Pinto, Andreia; Marques, Sofia; Faridi, Hafeez; Costa, Paulo; Gozzelino, Raffaella; Zhao, Jimmy L; Soares, Miguel P; Gama-Carvalho, Margarida; Martinez, Jennifer; Zhang, Qingshuo; Döring, Gerd; Grompe, Markus; Simas, J Pedro; Huber, Tobias B; Baltimore, David; Gupta, Vineet; Green, Douglas R; Ferreira, João A; Moita, Luis F.

In: IMMUNITY, Vol. 39, No. 5, 14.11.2013, p. 874-84.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Figueiredo, N, Chora, A, Raquel, H, Pejanovic, N, Pereira, P, Hartleben, B, Neves-Costa, A, Moita, C, Pedroso, D, Pinto, A, Marques, S, Faridi, H, Costa, P, Gozzelino, R, Zhao, JL, Soares, MP, Gama-Carvalho, M, Martinez, J, Zhang, Q, Döring, G, Grompe, M, Simas, JP, Huber, TB, Baltimore, D, Gupta, V, Green, DR, Ferreira, JA & Moita, LF 2013, 'Anthracyclines induce DNA damage response-mediated protection against severe sepsis', IMMUNITY, vol. 39, no. 5, pp. 874-84. https://doi.org/10.1016/j.immuni.2013.08.039

APA

Figueiredo, N., Chora, A., Raquel, H., Pejanovic, N., Pereira, P., Hartleben, B., Neves-Costa, A., Moita, C., Pedroso, D., Pinto, A., Marques, S., Faridi, H., Costa, P., Gozzelino, R., Zhao, J. L., Soares, M. P., Gama-Carvalho, M., Martinez, J., Zhang, Q., ... Moita, L. F. (2013). Anthracyclines induce DNA damage response-mediated protection against severe sepsis. IMMUNITY, 39(5), 874-84. https://doi.org/10.1016/j.immuni.2013.08.039

Vancouver

Figueiredo N, Chora A, Raquel H, Pejanovic N, Pereira P, Hartleben B et al. Anthracyclines induce DNA damage response-mediated protection against severe sepsis. IMMUNITY. 2013 Nov 14;39(5):874-84. https://doi.org/10.1016/j.immuni.2013.08.039

Bibtex

@article{09d1cc243cca4fe397c036f627140c13,
title = "Anthracyclines induce DNA damage response-mediated protection against severe sepsis",
abstract = "Severe sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options in addition to organ support measures. Here we show that the clinically approved group of anthracyclines acts therapeutically at a low dose regimen to confer robust protection against severe sepsis in mice. This salutary effect is strictly dependent on the activation of DNA damage response and autophagy pathways in the lung, as demonstrated by deletion of the ataxia telangiectasia mutated (Atm) or the autophagy-related protein 7 (Atg7) specifically in this organ. The protective effect of anthracyclines occurs irrespectively of pathogen burden, conferring disease tolerance to severe sepsis. These findings demonstrate that DNA damage responses, including the ATM and Fanconi Anemia pathways, are important modulators of immune responses and might be exploited to confer protection to inflammation-driven conditions, including severe sepsis.",
keywords = "Adenoviridae Infections, Animals, Anthracyclines, Anti-Bacterial Agents, Ataxia Telangiectasia Mutated Proteins, Autophagy-Related Protein 7, Cecum, DNA Damage, DNA Repair, Epirubicin, Fanconi Anemia Complementation Group D2 Protein, Inflammation, Inflammation Mediators, Injections, Intraperitoneal, Lung, Mice, Mice, Inbred C57BL, Microtubule-Associated Proteins, Organ Specificity, Peritonitis, Respiratory Tract Infections, Sepsis, Shock, Septic, Thienamycins, Whole-Body Irradiation, Journal Article, Research Support, Non-U.S. Gov't",
author = "Nuno Figueiredo and Angelo Chora and Helena Raquel and Nadja Pejanovic and Pedro Pereira and Bj{\"o}rn Hartleben and Ana Neves-Costa and Catarina Moita and Dora Pedroso and Andreia Pinto and Sofia Marques and Hafeez Faridi and Paulo Costa and Raffaella Gozzelino and Zhao, {Jimmy L} and Soares, {Miguel P} and Margarida Gama-Carvalho and Jennifer Martinez and Qingshuo Zhang and Gerd D{\"o}ring and Markus Grompe and Simas, {J Pedro} and Huber, {Tobias B} and David Baltimore and Vineet Gupta and Green, {Douglas R} and Ferreira, {Jo{\~a}o A} and Moita, {Luis F}",
note = "Copyright {\textcopyright} 2013 Elsevier Inc. All rights reserved.",
year = "2013",
month = nov,
day = "14",
doi = "10.1016/j.immuni.2013.08.039",
language = "English",
volume = "39",
pages = "874--84",
journal = "IMMUNITY",
issn = "1074-7613",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Anthracyclines induce DNA damage response-mediated protection against severe sepsis

AU - Figueiredo, Nuno

AU - Chora, Angelo

AU - Raquel, Helena

AU - Pejanovic, Nadja

AU - Pereira, Pedro

AU - Hartleben, Björn

AU - Neves-Costa, Ana

AU - Moita, Catarina

AU - Pedroso, Dora

AU - Pinto, Andreia

AU - Marques, Sofia

AU - Faridi, Hafeez

AU - Costa, Paulo

AU - Gozzelino, Raffaella

AU - Zhao, Jimmy L

AU - Soares, Miguel P

AU - Gama-Carvalho, Margarida

AU - Martinez, Jennifer

AU - Zhang, Qingshuo

AU - Döring, Gerd

AU - Grompe, Markus

AU - Simas, J Pedro

AU - Huber, Tobias B

AU - Baltimore, David

AU - Gupta, Vineet

AU - Green, Douglas R

AU - Ferreira, João A

AU - Moita, Luis F

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2013/11/14

Y1 - 2013/11/14

N2 - Severe sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options in addition to organ support measures. Here we show that the clinically approved group of anthracyclines acts therapeutically at a low dose regimen to confer robust protection against severe sepsis in mice. This salutary effect is strictly dependent on the activation of DNA damage response and autophagy pathways in the lung, as demonstrated by deletion of the ataxia telangiectasia mutated (Atm) or the autophagy-related protein 7 (Atg7) specifically in this organ. The protective effect of anthracyclines occurs irrespectively of pathogen burden, conferring disease tolerance to severe sepsis. These findings demonstrate that DNA damage responses, including the ATM and Fanconi Anemia pathways, are important modulators of immune responses and might be exploited to confer protection to inflammation-driven conditions, including severe sepsis.

AB - Severe sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options in addition to organ support measures. Here we show that the clinically approved group of anthracyclines acts therapeutically at a low dose regimen to confer robust protection against severe sepsis in mice. This salutary effect is strictly dependent on the activation of DNA damage response and autophagy pathways in the lung, as demonstrated by deletion of the ataxia telangiectasia mutated (Atm) or the autophagy-related protein 7 (Atg7) specifically in this organ. The protective effect of anthracyclines occurs irrespectively of pathogen burden, conferring disease tolerance to severe sepsis. These findings demonstrate that DNA damage responses, including the ATM and Fanconi Anemia pathways, are important modulators of immune responses and might be exploited to confer protection to inflammation-driven conditions, including severe sepsis.

KW - Adenoviridae Infections

KW - Animals

KW - Anthracyclines

KW - Anti-Bacterial Agents

KW - Ataxia Telangiectasia Mutated Proteins

KW - Autophagy-Related Protein 7

KW - Cecum

KW - DNA Damage

KW - DNA Repair

KW - Epirubicin

KW - Fanconi Anemia Complementation Group D2 Protein

KW - Inflammation

KW - Inflammation Mediators

KW - Injections, Intraperitoneal

KW - Lung

KW - Mice

KW - Mice, Inbred C57BL

KW - Microtubule-Associated Proteins

KW - Organ Specificity

KW - Peritonitis

KW - Respiratory Tract Infections

KW - Sepsis

KW - Shock, Septic

KW - Thienamycins

KW - Whole-Body Irradiation

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.immuni.2013.08.039

DO - 10.1016/j.immuni.2013.08.039

M3 - SCORING: Journal article

C2 - 24184056

VL - 39

SP - 874

EP - 884

JO - IMMUNITY

JF - IMMUNITY

SN - 1074-7613

IS - 5

ER -