Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review)
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Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review). / Müller, I; Niethammer, D; Bruchelt, G.
In: INT J MOL MED, Vol. 1, No. 2, 02.1998, p. 491-4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review)
AU - Müller, I
AU - Niethammer, D
AU - Bruchelt, G
PY - 1998/2
Y1 - 1998/2
N2 - Anthracycline-derivatives are frequently used chemotherapeutics in treatment of numerous human malignancies. Anthracyclines are known for their complex cytotoxic mechanism involving i) inhibition of enzymes such as topoisomerase II, RNA polymerase, cytochrome c oxidase and others; ii) intercalation into DNA; iii) chelation of iron and generation of reactive oxygen species (ROS); iv) induction of apoptosis. Here, mechanistic aspects for successful cytostasis and for side effects, e.g. cardiomyopathy, are discussed. We emphasize recent developments in anthracycline-mediated apoptosis and focus on a well known representative, doxorubicin (adriamycin, adriblastin). We reflect on the role of oxidative stress and interactions with intracellular signaling pathways.
AB - Anthracycline-derivatives are frequently used chemotherapeutics in treatment of numerous human malignancies. Anthracyclines are known for their complex cytotoxic mechanism involving i) inhibition of enzymes such as topoisomerase II, RNA polymerase, cytochrome c oxidase and others; ii) intercalation into DNA; iii) chelation of iron and generation of reactive oxygen species (ROS); iv) induction of apoptosis. Here, mechanistic aspects for successful cytostasis and for side effects, e.g. cardiomyopathy, are discussed. We emphasize recent developments in anthracycline-mediated apoptosis and focus on a well known representative, doxorubicin (adriamycin, adriblastin). We reflect on the role of oxidative stress and interactions with intracellular signaling pathways.
KW - Animals
KW - Anthracyclines
KW - Apoptosis
KW - Calcium-Calmodulin-Dependent Protein Kinases
KW - Doxorubicin
KW - Drug Resistance
KW - Free Radicals
KW - Humans
KW - JNK Mitogen-Activated Protein Kinases
KW - Mitogen-Activated Protein Kinases
M3 - SCORING: Journal article
C2 - 9852255
VL - 1
SP - 491
EP - 494
JO - INT J MOL MED
JF - INT J MOL MED
SN - 1107-3756
IS - 2
ER -
