[Anthracycline transport in sensitive and resistant leukemia cells]

Rudolf Erttmann; Norbert Erb; P Forcadell de Dios; C Neurath; G Looft; G Landbeck

[Anthracycline transport in sensitive and resistant leukemia cells]

Standard

[Anthracycline transport in sensitive and resistant leukemia cells]. / Erttmann, Rudolf; Erb, Norbert; Forcadell de Dios, P; Neurath, C; Looft, G; Landbeck, G.

In: KLIN PADIATR, Vol. 201, No. 1, 1, 1989, p. 40-45.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Erttmann, R, Erb, N, Forcadell de Dios, P, Neurath, C, Looft, G & Landbeck, G 1989, '[Anthracycline transport in sensitive and resistant leukemia cells]', KLIN PADIATR, vol. 201, no. 1, 1, pp. 40-45. <http://www.ncbi.nlm.nih.gov/pubmed/2704176?dopt=Citation>

APA

Erttmann, R., Erb, N., Forcadell de Dios, P., Neurath, C., Looft, G., & Landbeck, G. (1989). [Anthracycline transport in sensitive and resistant leukemia cells]. KLIN PADIATR, 201(1), 40-45. [1]. http://www.ncbi.nlm.nih.gov/pubmed/2704176?dopt=Citation

Vancouver

Erttmann R, Erb N, Forcadell de Dios P, Neurath C, Looft G, Landbeck G. [Anthracycline transport in sensitive and resistant leukemia cells]. KLIN PADIATR. 1989;201(1):40-45. 1.

Bibtex

@article{9f0c9b4299f7499d95c46ac2bfe08058,

title = "[Anthracycline transport in sensitive and resistant leukemia cells]",

abstract = "The in-vitro uptake of four anthracyclines into leukemic cells was investigated. The accumulation was found to be dependent on the extracellular anthracycline concentration in a linear fashion. The steady state intracellular drug level was reached very quickly and was found to be correlated to the extracellular pH-value in the range between 6.4 and 7.4. Intracellular anthracycline accumulation was restricted in a leukemic subline (F 4-6 R), which was found to be 86 times more resistant to doxorubicin compared with its wild tpye (F 4-6). The importance of the initial uptake phase of anthracyclines into leukemic cells raises the question whether long-term {"}cardioprotective{"} anthracycline application schedules will retain the same antileukemic effect as conventional bolus injection.",

author = "Rudolf Erttmann and Norbert Erb and {Forcadell de Dios}, P and C Neurath and G Looft and G Landbeck",

year = "1989",

language = "Deutsch",

volume = "201",

pages = "40--45",

journal = "KLIN PADIATR",

issn = "0300-8630",

publisher = "Georg Thieme Verlag KG",

number = "1",

}

RIS

TY - JOUR

T1 - [Anthracycline transport in sensitive and resistant leukemia cells]

AU - Erttmann, Rudolf

AU - Erb, Norbert

AU - Forcadell de Dios, P

AU - Neurath, C

AU - Looft, G

AU - Landbeck, G

PY - 1989

Y1 - 1989

N2 - The in-vitro uptake of four anthracyclines into leukemic cells was investigated. The accumulation was found to be dependent on the extracellular anthracycline concentration in a linear fashion. The steady state intracellular drug level was reached very quickly and was found to be correlated to the extracellular pH-value in the range between 6.4 and 7.4. Intracellular anthracycline accumulation was restricted in a leukemic subline (F 4-6 R), which was found to be 86 times more resistant to doxorubicin compared with its wild tpye (F 4-6). The importance of the initial uptake phase of anthracyclines into leukemic cells raises the question whether long-term "cardioprotective" anthracycline application schedules will retain the same antileukemic effect as conventional bolus injection.

AB - The in-vitro uptake of four anthracyclines into leukemic cells was investigated. The accumulation was found to be dependent on the extracellular anthracycline concentration in a linear fashion. The steady state intracellular drug level was reached very quickly and was found to be correlated to the extracellular pH-value in the range between 6.4 and 7.4. Intracellular anthracycline accumulation was restricted in a leukemic subline (F 4-6 R), which was found to be 86 times more resistant to doxorubicin compared with its wild tpye (F 4-6). The importance of the initial uptake phase of anthracyclines into leukemic cells raises the question whether long-term "cardioprotective" anthracycline application schedules will retain the same antileukemic effect as conventional bolus injection.

M3 - SCORING: Zeitschriftenaufsatz

VL - 201

SP - 40

EP - 45

JO - KLIN PADIATR

JF - KLIN PADIATR

SN - 0300-8630

IS - 1

M1 - 1

ER -