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Anterior Pituitary Hormones in Blood and Cerebrospinal Fluid of Patients in Neurocritical Care

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Anterior Pituitary Hormones in Blood and Cerebrospinal Fluid of Patients in Neurocritical Care. / Beyer, Henriette; Lange, Nicole; Podtschaske, Armin H; Martin, Jan; Albers, Lucia; von Werder, Alexander; Ruland, Jürgen; Schneider, Gerhard; Meyer, Bernhard; Kagerbauer, Simone M; Gempt, Jens.

In: TouchREVIEWS in endocrinology, Vol. 18, No. 1, 06.2022, p. 71-79.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Beyer, H, Lange, N, Podtschaske, AH, Martin, J, Albers, L, von Werder, A, Ruland, J, Schneider, G, Meyer, B, Kagerbauer, SM & Gempt, J 2022, 'Anterior Pituitary Hormones in Blood and Cerebrospinal Fluid of Patients in Neurocritical Care', TouchREVIEWS in endocrinology, vol. 18, no. 1, pp. 71-79. https://doi.org/10.17925/EE.2022.18.1.71

APA

Beyer, H., Lange, N., Podtschaske, A. H., Martin, J., Albers, L., von Werder, A., Ruland, J., Schneider, G., Meyer, B., Kagerbauer, S. M., & Gempt, J. (2022). Anterior Pituitary Hormones in Blood and Cerebrospinal Fluid of Patients in Neurocritical Care. TouchREVIEWS in endocrinology, 18(1), 71-79. https://doi.org/10.17925/EE.2022.18.1.71

Vancouver

Beyer H, Lange N, Podtschaske AH, Martin J, Albers L, von Werder A et al. Anterior Pituitary Hormones in Blood and Cerebrospinal Fluid of Patients in Neurocritical Care. TouchREVIEWS in endocrinology. 2022 Jun;18(1):71-79. https://doi.org/10.17925/EE.2022.18.1.71

Bibtex

@article{282210cb9dc943aea10386e8dcda7ed8,
title = "Anterior Pituitary Hormones in Blood and Cerebrospinal Fluid of Patients in Neurocritical Care",
abstract = "BACKGROUND: Anterior pituitary hormones in blood follow a circadian rhythm, which may be influenced by various factors such as intracranial pathologies. In cerebrospinal fluid (CSF), pituitary hormones have been collected only selectively and circadian rhythm has not yet been investigated. This pilot study analysed diurnal variations of anterior pituitary hormones in patients in neurocritical care to determine whether circadian rhythmicity exists in these patients. Possible influences of intracranial pathologies were also investigated. Blood and CSF concentrations were assessed simultaneously to explore the value of blood concentrations as a surrogate parameter for CSF levels.METHODS: Blood and CSF samples of 20 non-sedated patients were collected at 06:00, noon, 18:00 and midnight, and analysed for adrenocorticotropic hormone (ACTH), cortisol, thyroid-stimulating hormone (TSH) and insulin-like growth factor-1 (IGF-1) concentrations at each of the four time points. ACTH and IGF-1 were measured by sandwich chemiluminescence immunoassay. Cortisol and TSH were measured by electrochemiluminescence immunoassay.RESULTS: Results showed inconsistent circadian rhythms. Less than 50% of the patients showed a circadian rhythmicity of ACTH, cortisol, TSH or IGF-1. Significance of diurnal variations was only present for blood concentrations of TSH. Correlations between blood and CSF concentrations were strong for cortisol and TSH.CONCLUSIONS: CSF concentrations were only in the measurable range in some of the patients. No clear circadian rhythmicity could be identified, except for TSH in blood. Absence of significant diurnal variations could be explained by the underlying pathologies or disturbing influences of the intensive care unit. Blood concentrations of cortisol and TSH may be suitable surrogate parameters for CSF.",
author = "Henriette Beyer and Nicole Lange and Podtschaske, {Armin H} and Jan Martin and Lucia Albers and {von Werder}, Alexander and J{\"u}rgen Ruland and Gerhard Schneider and Bernhard Meyer and Kagerbauer, {Simone M} and Jens Gempt",
note = "{\textcopyright} Touch Medical Media 2022.",
year = "2022",
month = jun,
doi = "10.17925/EE.2022.18.1.71",
language = "English",
volume = "18",
pages = "71--79",
number = "1",

}

RIS

TY - JOUR

T1 - Anterior Pituitary Hormones in Blood and Cerebrospinal Fluid of Patients in Neurocritical Care

AU - Beyer, Henriette

AU - Lange, Nicole

AU - Podtschaske, Armin H

AU - Martin, Jan

AU - Albers, Lucia

AU - von Werder, Alexander

AU - Ruland, Jürgen

AU - Schneider, Gerhard

AU - Meyer, Bernhard

AU - Kagerbauer, Simone M

AU - Gempt, Jens

N1 - © Touch Medical Media 2022.

PY - 2022/6

Y1 - 2022/6

N2 - BACKGROUND: Anterior pituitary hormones in blood follow a circadian rhythm, which may be influenced by various factors such as intracranial pathologies. In cerebrospinal fluid (CSF), pituitary hormones have been collected only selectively and circadian rhythm has not yet been investigated. This pilot study analysed diurnal variations of anterior pituitary hormones in patients in neurocritical care to determine whether circadian rhythmicity exists in these patients. Possible influences of intracranial pathologies were also investigated. Blood and CSF concentrations were assessed simultaneously to explore the value of blood concentrations as a surrogate parameter for CSF levels.METHODS: Blood and CSF samples of 20 non-sedated patients were collected at 06:00, noon, 18:00 and midnight, and analysed for adrenocorticotropic hormone (ACTH), cortisol, thyroid-stimulating hormone (TSH) and insulin-like growth factor-1 (IGF-1) concentrations at each of the four time points. ACTH and IGF-1 were measured by sandwich chemiluminescence immunoassay. Cortisol and TSH were measured by electrochemiluminescence immunoassay.RESULTS: Results showed inconsistent circadian rhythms. Less than 50% of the patients showed a circadian rhythmicity of ACTH, cortisol, TSH or IGF-1. Significance of diurnal variations was only present for blood concentrations of TSH. Correlations between blood and CSF concentrations were strong for cortisol and TSH.CONCLUSIONS: CSF concentrations were only in the measurable range in some of the patients. No clear circadian rhythmicity could be identified, except for TSH in blood. Absence of significant diurnal variations could be explained by the underlying pathologies or disturbing influences of the intensive care unit. Blood concentrations of cortisol and TSH may be suitable surrogate parameters for CSF.

AB - BACKGROUND: Anterior pituitary hormones in blood follow a circadian rhythm, which may be influenced by various factors such as intracranial pathologies. In cerebrospinal fluid (CSF), pituitary hormones have been collected only selectively and circadian rhythm has not yet been investigated. This pilot study analysed diurnal variations of anterior pituitary hormones in patients in neurocritical care to determine whether circadian rhythmicity exists in these patients. Possible influences of intracranial pathologies were also investigated. Blood and CSF concentrations were assessed simultaneously to explore the value of blood concentrations as a surrogate parameter for CSF levels.METHODS: Blood and CSF samples of 20 non-sedated patients were collected at 06:00, noon, 18:00 and midnight, and analysed for adrenocorticotropic hormone (ACTH), cortisol, thyroid-stimulating hormone (TSH) and insulin-like growth factor-1 (IGF-1) concentrations at each of the four time points. ACTH and IGF-1 were measured by sandwich chemiluminescence immunoassay. Cortisol and TSH were measured by electrochemiluminescence immunoassay.RESULTS: Results showed inconsistent circadian rhythms. Less than 50% of the patients showed a circadian rhythmicity of ACTH, cortisol, TSH or IGF-1. Significance of diurnal variations was only present for blood concentrations of TSH. Correlations between blood and CSF concentrations were strong for cortisol and TSH.CONCLUSIONS: CSF concentrations were only in the measurable range in some of the patients. No clear circadian rhythmicity could be identified, except for TSH in blood. Absence of significant diurnal variations could be explained by the underlying pathologies or disturbing influences of the intensive care unit. Blood concentrations of cortisol and TSH may be suitable surrogate parameters for CSF.

U2 - 10.17925/EE.2022.18.1.71

DO - 10.17925/EE.2022.18.1.71

M3 - SCORING: Journal article

C2 - 35949361

VL - 18

SP - 71

EP - 79

IS - 1

ER -