Anterior and posterior corneal changes after crosslinking for keratoconus
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Anterior and posterior corneal changes after crosslinking for keratoconus. / Steinberg, Johannes; Ahmadiyar, Mariam; Rost, Anika; Frings, Andreas; Filev, Filip; Katz, Toam; Linke, Stephan J.
In: OPTOMETRY VISION SCI, Vol. 91, No. 2, 2014, p. 178-86.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Anterior and posterior corneal changes after crosslinking for keratoconus
AU - Steinberg, Johannes
AU - Ahmadiyar, Mariam
AU - Rost, Anika
AU - Frings, Andreas
AU - Filev, Filip
AU - Katz, Toam
AU - Linke, Stephan J
PY - 2014
Y1 - 2014
N2 - PURPOSE: To evaluate anterior and posterior changes in corneal topography and tomography after corneal crosslinking (CXL) in eyes with progressive keratoconus.METHODS: Scheimpflug analyses (Pentacam, Oculus) of 20 eyes with keratoconus performed before and after corneal CXL were included into retrospective analysis. Mean follow-up was 2 years. Changes in topographic, tomographic, and pachymetric values were statistically analyzed applying analysis of variance. Further, the distance and direction between the anterior maximum keratometry (K(max)) and the apex as well as the distance and direction between the thinnest point in corneal thickness (TPCT) and the corneal apex before and after CXL were studied.RESULTS: Two years after CXL, a statistically significant reduction of the keratometry at the flat meridian (-0.8 D, p < 0.05), the steep meridian (-0.5 D, p < 0.05), the "index of surface variance" (-5.3, p < 0.05), and the "index of highest decentration" (-0.05, p < 0.05) could be demonstrated. While the elevation of the front surface at the apex decreased (-1.5 μm, p < 0.05), the back elevation at the apex (+2 μm, p < 0.05) increased. Although not reaching statistical significance, the maximum front and back elevation demonstrated the same trend; while maximum front elevation data remained stable (-0.3 μm, p = 0.961), maximum back elevation data increased (+6.7 μm, p = 0.122). The corneal thickness at the apex (-22.0 μm, p < 0.001) and the TPCT (-20.0 μm, p < 0.001) decreased, leading to an increase of the corneal thickness progression from the corneal apex to the periphery. The position of K(max) and TPCT remained stable.CONCLUSIONS: Corneal topography proved to be useful in the follow-up for CXL because of significant changes in the keratometry. Increasing posterior elevation values, despite a stabilized anterior corneal surface, might be a sign of ongoing ectatic changes in the posterior corneal surface.
AB - PURPOSE: To evaluate anterior and posterior changes in corneal topography and tomography after corneal crosslinking (CXL) in eyes with progressive keratoconus.METHODS: Scheimpflug analyses (Pentacam, Oculus) of 20 eyes with keratoconus performed before and after corneal CXL were included into retrospective analysis. Mean follow-up was 2 years. Changes in topographic, tomographic, and pachymetric values were statistically analyzed applying analysis of variance. Further, the distance and direction between the anterior maximum keratometry (K(max)) and the apex as well as the distance and direction between the thinnest point in corneal thickness (TPCT) and the corneal apex before and after CXL were studied.RESULTS: Two years after CXL, a statistically significant reduction of the keratometry at the flat meridian (-0.8 D, p < 0.05), the steep meridian (-0.5 D, p < 0.05), the "index of surface variance" (-5.3, p < 0.05), and the "index of highest decentration" (-0.05, p < 0.05) could be demonstrated. While the elevation of the front surface at the apex decreased (-1.5 μm, p < 0.05), the back elevation at the apex (+2 μm, p < 0.05) increased. Although not reaching statistical significance, the maximum front and back elevation demonstrated the same trend; while maximum front elevation data remained stable (-0.3 μm, p = 0.961), maximum back elevation data increased (+6.7 μm, p = 0.122). The corneal thickness at the apex (-22.0 μm, p < 0.001) and the TPCT (-20.0 μm, p < 0.001) decreased, leading to an increase of the corneal thickness progression from the corneal apex to the periphery. The position of K(max) and TPCT remained stable.CONCLUSIONS: Corneal topography proved to be useful in the follow-up for CXL because of significant changes in the keratometry. Increasing posterior elevation values, despite a stabilized anterior corneal surface, might be a sign of ongoing ectatic changes in the posterior corneal surface.
KW - Adolescent
KW - Adult
KW - Collagen
KW - Cornea
KW - Corneal Pachymetry
KW - Corneal Stroma
KW - Corneal Topography
KW - Cross-Linking Reagents
KW - Female
KW - Humans
KW - Keratoconus
KW - Male
KW - Middle Aged
KW - Photochemotherapy
KW - Photosensitizing Agents
KW - Retrospective Studies
KW - Riboflavin
KW - Tomography, Optical Coherence
KW - Ultraviolet Rays
KW - Young Adult
U2 - 10.1097/OPX.0000000000000141
DO - 10.1097/OPX.0000000000000141
M3 - SCORING: Journal article
C2 - 24445720
VL - 91
SP - 178
EP - 186
JO - OPTOMETRY VISION SCI
JF - OPTOMETRY VISION SCI
SN - 1040-5488
IS - 2
ER -