Animal models for the study of HBV replication and its variants.

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Animal models for the study of HBV replication and its variants. / Dandri-Petersen, Maura; Volz, Tassilo; Lütgehetmann, Marc; Petersen, J.

In: J CLIN VIROL, Vol. 34, No. 1, 1, 2005, p. 54-62.

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@article{855ee6815dcc46bcae011f2bd6754a6d,
title = "Animal models for the study of HBV replication and its variants.",
abstract = "Enormous progresses in hepatitis B virus research have been made through the identification of avian and mammalian HBV related viruses, which offer ample opportunities for studies in naturally occurring hosts. However, none of these natural hosts belongs to the commonly used laboratory animals, and the development of various mouse strains carrying HBV transgenes offered unique opportunities to investigate some mechanisms of viral pathogenesis. Furthermore, the need to perform infection studies in a system harbouring HBV-permissive hepatocytes has lately led researchers to create new challenging human mouse chimera models of HBV infection. In this review, we will overview the type of animal models currently available in hepadnavirus research.",
author = "Maura Dandri-Petersen and Tassilo Volz and Marc L{\"u}tgehetmann and J Petersen",
year = "2005",
language = "Deutsch",
volume = "34",
pages = "54--62",
journal = "J CLIN VIROL",
issn = "1386-6532",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Animal models for the study of HBV replication and its variants.

AU - Dandri-Petersen, Maura

AU - Volz, Tassilo

AU - Lütgehetmann, Marc

AU - Petersen, J

PY - 2005

Y1 - 2005

N2 - Enormous progresses in hepatitis B virus research have been made through the identification of avian and mammalian HBV related viruses, which offer ample opportunities for studies in naturally occurring hosts. However, none of these natural hosts belongs to the commonly used laboratory animals, and the development of various mouse strains carrying HBV transgenes offered unique opportunities to investigate some mechanisms of viral pathogenesis. Furthermore, the need to perform infection studies in a system harbouring HBV-permissive hepatocytes has lately led researchers to create new challenging human mouse chimera models of HBV infection. In this review, we will overview the type of animal models currently available in hepadnavirus research.

AB - Enormous progresses in hepatitis B virus research have been made through the identification of avian and mammalian HBV related viruses, which offer ample opportunities for studies in naturally occurring hosts. However, none of these natural hosts belongs to the commonly used laboratory animals, and the development of various mouse strains carrying HBV transgenes offered unique opportunities to investigate some mechanisms of viral pathogenesis. Furthermore, the need to perform infection studies in a system harbouring HBV-permissive hepatocytes has lately led researchers to create new challenging human mouse chimera models of HBV infection. In this review, we will overview the type of animal models currently available in hepadnavirus research.

M3 - SCORING: Zeitschriftenaufsatz

VL - 34

SP - 54

EP - 62

JO - J CLIN VIROL

JF - J CLIN VIROL

SN - 1386-6532

IS - 1

M1 - 1

ER -