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Angiogenesis inhibition by angiostatin, endostatin and TNP-470 prevents cyclophosphamide induced cystitis.

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Angiogenesis inhibition by angiostatin, endostatin and TNP-470 prevents cyclophosphamide induced cystitis. / Beecken, Wolf-Dietrich; Engl, Tobias; Blaheta, Roman; Bentas, Wassilios; Achilles, Eike-Gert; Jonas, Dietger; Shing, Yuen; Camphausen, Kevin.

In: ANGIOGENESIS, Vol. 7, No. 1, 1, 2004, p. 69-73.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Beecken, W-D, Engl, T, Blaheta, R, Bentas, W, Achilles, E-G, Jonas, D, Shing, Y & Camphausen, K 2004, 'Angiogenesis inhibition by angiostatin, endostatin and TNP-470 prevents cyclophosphamide induced cystitis.', ANGIOGENESIS, vol. 7, no. 1, 1, pp. 69-73. <http://www.ncbi.nlm.nih.gov/pubmed/15302998?dopt=Citation>

APA

Beecken, W-D., Engl, T., Blaheta, R., Bentas, W., Achilles, E-G., Jonas, D., Shing, Y., & Camphausen, K. (2004). Angiogenesis inhibition by angiostatin, endostatin and TNP-470 prevents cyclophosphamide induced cystitis. ANGIOGENESIS, 7(1), 69-73. [1]. http://www.ncbi.nlm.nih.gov/pubmed/15302998?dopt=Citation

Vancouver

Beecken W-D, Engl T, Blaheta R, Bentas W, Achilles E-G, Jonas D et al. Angiogenesis inhibition by angiostatin, endostatin and TNP-470 prevents cyclophosphamide induced cystitis. ANGIOGENESIS. 2004;7(1):69-73. 1.

Bibtex

@article{94aeda59f9c04c3fadce3961501533ef,
title = "Angiogenesis inhibition by angiostatin, endostatin and TNP-470 prevents cyclophosphamide induced cystitis.",
abstract = "Angiogenesis, the induction of vessel growth is involved in numerous physiological and pathological processes. While the anti-tumor effect of angiogenesis inhibitors has been extensively investigated in malignant tumors, there is very little information on the effect of angiogenesis inhibitors on inflammation induced angiogenesis. In this report, we utilized a murine model of acute chemically induced cystitis to investigate the ability of three different angiogenesis inhibitors, angiostatin, endostatin and TNP-470, to inhibit the angiogenesis stimulated by this injury. We demonstrate herein, that prophylactic application of the angiogenesis inhibitors led to a significant reduction of each of the inflammatory parameters that were measured. We conclude that anti-angiogenic therapy with angiostatin, endostatin and TNP-470 inhibits inflammation associated angiogenesis induced in this model. We also propose that anti-angiogenic agents may serve as a valuable addition to a standard cyclophosphamid chemotherapy regimen to help reduce the chemotherapy-related side effects while potentially adding an anti-tumor effect.",
author = "Wolf-Dietrich Beecken and Tobias Engl and Roman Blaheta and Wassilios Bentas and Eike-Gert Achilles and Dietger Jonas and Yuen Shing and Kevin Camphausen",
year = "2004",
language = "Deutsch",
volume = "7",
pages = "69--73",
journal = "ANGIOGENESIS",
issn = "0969-6970",
publisher = "Springer Netherlands",
number = "1",

}

RIS

TY - JOUR

T1 - Angiogenesis inhibition by angiostatin, endostatin and TNP-470 prevents cyclophosphamide induced cystitis.

AU - Beecken, Wolf-Dietrich

AU - Engl, Tobias

AU - Blaheta, Roman

AU - Bentas, Wassilios

AU - Achilles, Eike-Gert

AU - Jonas, Dietger

AU - Shing, Yuen

AU - Camphausen, Kevin

PY - 2004

Y1 - 2004

N2 - Angiogenesis, the induction of vessel growth is involved in numerous physiological and pathological processes. While the anti-tumor effect of angiogenesis inhibitors has been extensively investigated in malignant tumors, there is very little information on the effect of angiogenesis inhibitors on inflammation induced angiogenesis. In this report, we utilized a murine model of acute chemically induced cystitis to investigate the ability of three different angiogenesis inhibitors, angiostatin, endostatin and TNP-470, to inhibit the angiogenesis stimulated by this injury. We demonstrate herein, that prophylactic application of the angiogenesis inhibitors led to a significant reduction of each of the inflammatory parameters that were measured. We conclude that anti-angiogenic therapy with angiostatin, endostatin and TNP-470 inhibits inflammation associated angiogenesis induced in this model. We also propose that anti-angiogenic agents may serve as a valuable addition to a standard cyclophosphamid chemotherapy regimen to help reduce the chemotherapy-related side effects while potentially adding an anti-tumor effect.

AB - Angiogenesis, the induction of vessel growth is involved in numerous physiological and pathological processes. While the anti-tumor effect of angiogenesis inhibitors has been extensively investigated in malignant tumors, there is very little information on the effect of angiogenesis inhibitors on inflammation induced angiogenesis. In this report, we utilized a murine model of acute chemically induced cystitis to investigate the ability of three different angiogenesis inhibitors, angiostatin, endostatin and TNP-470, to inhibit the angiogenesis stimulated by this injury. We demonstrate herein, that prophylactic application of the angiogenesis inhibitors led to a significant reduction of each of the inflammatory parameters that were measured. We conclude that anti-angiogenic therapy with angiostatin, endostatin and TNP-470 inhibits inflammation associated angiogenesis induced in this model. We also propose that anti-angiogenic agents may serve as a valuable addition to a standard cyclophosphamid chemotherapy regimen to help reduce the chemotherapy-related side effects while potentially adding an anti-tumor effect.

M3 - SCORING: Zeitschriftenaufsatz

VL - 7

SP - 69

EP - 73

JO - ANGIOGENESIS

JF - ANGIOGENESIS

SN - 0969-6970

IS - 1

M1 - 1

ER -