Anesthesia and increased hypercarbic drive impair the coordination between breathing and swallowing
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Anesthesia and increased hypercarbic drive impair the coordination between breathing and swallowing. / D'Angelo, Olivia M; Diaz-Gil, Daniel; Nunn, Danuza; Simons, Jeroen C P; Gianatasio, Chloe; Mueller, Noomi; Meyer, Matthew J; Pierce, Eric; Rosow, Carl; Eikermann, Matthias.
In: ANESTHESIOLOGY, Vol. 121, No. 6, 12.2014, p. 1175-1183.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Anesthesia and increased hypercarbic drive impair the coordination between breathing and swallowing
AU - D'Angelo, Olivia M
AU - Diaz-Gil, Daniel
AU - Nunn, Danuza
AU - Simons, Jeroen C P
AU - Gianatasio, Chloe
AU - Mueller, Noomi
AU - Meyer, Matthew J
AU - Pierce, Eric
AU - Rosow, Carl
AU - Eikermann, Matthias
PY - 2014/12
Y1 - 2014/12
N2 - BACKGROUND: Coordination between breathing and swallowing helps prevent aspiration of foreign material into the respiratory tract. The authors examined the effects of anesthesia and hypercapnia on swallowing-breathing coordination.METHODS: In a randomized controlled crossover study, general anesthesia with propofol or sevoflurane was titrated using an up-down method to identify the threshold for suppression of the motor response to electrical stimulation of the forearm. Additional measurements included bispectral index, genioglossus electromyogram, ventilation (pneumotachometer), and hypopharyngeal pressure. During wakefulness and at each level of anesthesia, carbon dioxide was added to increase the end-tidal pressure by 4 and 8 mmHg. A swallow was defined as increased genioglossus activity with deglutition apnea and an increase in hypopharyngeal pressure. Spontaneous swallows were categorized as physiological (during expiration or followed by expiration) or pathological (during inspiration or followed by an inspiration).RESULTS: A total of 224 swallows were analyzed. Anesthesia increased the proportion of pathological swallows (25.9% vs. 4.9%) and decreased the number of swallows per hour (1.7±3.3 vs. 28.0±22.3) compared to wakefulness. During anesthesia, hypercapnia decreased hypopharyngeal pressure during inspiration (-14.1±3.7 vs. -8.7±2 mmHg) and increased minute ventilation, the proportion of pathological swallows (19.1% vs. 12.3%), and the number of swallows per hour (5.5±17.0. vs. 1.3±5.5).CONCLUSIONS: Anesthesia impaired the coordination between swallowing and respiration. Mild hypercapnia increased the frequency of swallowing during anesthesia and the likelihood of pathological swallowing. During anesthesia, the risk for aspiration may be further increased when ventilatory drive is stimulated.
AB - BACKGROUND: Coordination between breathing and swallowing helps prevent aspiration of foreign material into the respiratory tract. The authors examined the effects of anesthesia and hypercapnia on swallowing-breathing coordination.METHODS: In a randomized controlled crossover study, general anesthesia with propofol or sevoflurane was titrated using an up-down method to identify the threshold for suppression of the motor response to electrical stimulation of the forearm. Additional measurements included bispectral index, genioglossus electromyogram, ventilation (pneumotachometer), and hypopharyngeal pressure. During wakefulness and at each level of anesthesia, carbon dioxide was added to increase the end-tidal pressure by 4 and 8 mmHg. A swallow was defined as increased genioglossus activity with deglutition apnea and an increase in hypopharyngeal pressure. Spontaneous swallows were categorized as physiological (during expiration or followed by expiration) or pathological (during inspiration or followed by an inspiration).RESULTS: A total of 224 swallows were analyzed. Anesthesia increased the proportion of pathological swallows (25.9% vs. 4.9%) and decreased the number of swallows per hour (1.7±3.3 vs. 28.0±22.3) compared to wakefulness. During anesthesia, hypercapnia decreased hypopharyngeal pressure during inspiration (-14.1±3.7 vs. -8.7±2 mmHg) and increased minute ventilation, the proportion of pathological swallows (19.1% vs. 12.3%), and the number of swallows per hour (5.5±17.0. vs. 1.3±5.5).CONCLUSIONS: Anesthesia impaired the coordination between swallowing and respiration. Mild hypercapnia increased the frequency of swallowing during anesthesia and the likelihood of pathological swallowing. During anesthesia, the risk for aspiration may be further increased when ventilatory drive is stimulated.
KW - Adolescent
KW - Adult
KW - Anesthesia
KW - Anesthetics, Inhalation/pharmacology
KW - Anesthetics, Intravenous/pharmacology
KW - Cross-Over Studies
KW - Deglutition/drug effects
KW - Deglutition Disorders/chemically induced
KW - Drive
KW - Electromyography
KW - Female
KW - Humans
KW - Hypercapnia/physiopathology
KW - Hypopharynx/drug effects
KW - Male
KW - Methyl Ethers/pharmacology
KW - Middle Aged
KW - Propofol/pharmacology
KW - Respiration/drug effects
KW - Sevoflurane
KW - Young Adult
U2 - 10.1097/ALN.0000000000000462
DO - 10.1097/ALN.0000000000000462
M3 - SCORING: Journal article
C2 - 25275368
VL - 121
SP - 1175
EP - 1183
JO - ANESTHESIOLOGY
JF - ANESTHESIOLOGY
SN - 0003-3022
IS - 6
ER -
