Anatomic radical retropubic prostatectomy-long-term recurrence-free survival rates for localized prostate cancer.
Standard
Anatomic radical retropubic prostatectomy-long-term recurrence-free survival rates for localized prostate cancer. / Chun, Felix K-H; Graefen, Markus; Zacharias, Mario; Haese, Alexander; Steuber, Thomas; Schlomm, Thorsten; Walz, Jochen; Karakiewicz, Pierre I; Huland, Hartwig.
In: WORLD J UROL, Vol. 24, No. 3, 3, 2006, p. 273-280.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Anatomic radical retropubic prostatectomy-long-term recurrence-free survival rates for localized prostate cancer.
AU - Chun, Felix K-H
AU - Graefen, Markus
AU - Zacharias, Mario
AU - Haese, Alexander
AU - Steuber, Thomas
AU - Schlomm, Thorsten
AU - Walz, Jochen
AU - Karakiewicz, Pierre I
AU - Huland, Hartwig
PY - 2006
Y1 - 2006
N2 - Radical prostatectomy remains the mainstay for the treatment of localized prostate cancer. Long-term follow-up data showed excellent cancer control rates in several prostatectomy series. We report biochemical recurrence (BCR) outcomes after radical retropubic prostatectomy (RRP) in a European single center series of patients treated over a 13-year period. Between 1992 and 06/2005, 4,277 consecutive men underwent a RRP at the University Hospital Hamburg Eppendorf, Germany. Kaplan-Meier probabilities of BCR-free survival were determined for those patients with complete preoperative data, postoperative data, and follow-up information. Uni-and multivariate Cox regression models addressed PSA recurrence, defined as a PSA level > or = 0.1 ng/ml. Overall, BCR-free survival ranged between 84, 70 and 61% for 2, 5, and 8 years, respectively. In univariate and multivariate analyses, except for age and type of nerve-sparing technique, all traditional clinical and pathological variables represented statistically independent predictors of PSA recurrence-free survival (all P <or = 0.001). In organ-confined disease, the 10-year recurrence free survival rate was 80 and 30% in non-organ-confined cancers. Our findings confirm excellent long-term biochemical cancer-control outcomes after RRP. High grade prostate cancer at final pathology and seminal vesicle invasion proved to be the strongest risk factors of BCR after surgery.
AB - Radical prostatectomy remains the mainstay for the treatment of localized prostate cancer. Long-term follow-up data showed excellent cancer control rates in several prostatectomy series. We report biochemical recurrence (BCR) outcomes after radical retropubic prostatectomy (RRP) in a European single center series of patients treated over a 13-year period. Between 1992 and 06/2005, 4,277 consecutive men underwent a RRP at the University Hospital Hamburg Eppendorf, Germany. Kaplan-Meier probabilities of BCR-free survival were determined for those patients with complete preoperative data, postoperative data, and follow-up information. Uni-and multivariate Cox regression models addressed PSA recurrence, defined as a PSA level > or = 0.1 ng/ml. Overall, BCR-free survival ranged between 84, 70 and 61% for 2, 5, and 8 years, respectively. In univariate and multivariate analyses, except for age and type of nerve-sparing technique, all traditional clinical and pathological variables represented statistically independent predictors of PSA recurrence-free survival (all P <or = 0.001). In organ-confined disease, the 10-year recurrence free survival rate was 80 and 30% in non-organ-confined cancers. Our findings confirm excellent long-term biochemical cancer-control outcomes after RRP. High grade prostate cancer at final pathology and seminal vesicle invasion proved to be the strongest risk factors of BCR after surgery.
M3 - SCORING: Zeitschriftenaufsatz
VL - 24
SP - 273
EP - 280
JO - WORLD J UROL
JF - WORLD J UROL
SN - 0724-4983
IS - 3
M1 - 3
ER -
