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Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors

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Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors. / Fuchs, Jörg; Seitz, Guido; Ellerkamp, Verena; Dietz, Klaus; Bosk, Axel; Müller, Ingo; Warmann, Steven W; Schäfer, Jürgen F.

In: J SURG ONCOL, Vol. 17, No. 4, 12.2008, p. 323-30.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fuchs, J, Seitz, G, Ellerkamp, V, Dietz, K, Bosk, A, Müller, I, Warmann, SW & Schäfer, JF 2008, 'Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors', J SURG ONCOL, vol. 17, no. 4, pp. 323-30. https://doi.org/10.1016/j.suronc.2008.05.004

APA

Fuchs, J., Seitz, G., Ellerkamp, V., Dietz, K., Bosk, A., Müller, I., Warmann, S. W., & Schäfer, J. F. (2008). Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors. J SURG ONCOL, 17(4), 323-30. https://doi.org/10.1016/j.suronc.2008.05.004

Vancouver

Fuchs J, Seitz G, Ellerkamp V, Dietz K, Bosk A, Müller I et al. Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors. J SURG ONCOL. 2008 Dec;17(4):323-30. https://doi.org/10.1016/j.suronc.2008.05.004

Bibtex

@article{fb91620059634268ba7e0205dd9a023e,
title = "Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors",
abstract = "BACKGROUND: Radical surgical resection of metastases is an important prognostic factor for survival of patients suffering from solid pediatric tumors. The aim of this study is to evaluate the efficacy of median sternotomy as treatment option for the resection of multiple bilateral lung metastases in children with different tumor entities. Furthermore, the sensitivity of preoperative imaging (CT) was assessed by intraoperative findings.PATIENTS AND METHODS: Between 2002 and 2007, 13 children (4 with sarcoma, 4 with nephroblastoma, 5 with hepatoblastoma) underwent median sternotomy for resection of bilateral lung metastases after R0-resection of the primary tumor. In 6/13 cases, the sternotomy was combined with the primary tumor resection.RESULTS: Median patient age at the first operation was 5 years (range: 11 months to 17 years). The median total number of resected metastases per operation was 9 and ranged from 0 to 65. In 13/16 operations, the intraoperative number of metastases did not agree with the preoperative radiological work-up. Median hospital stay was 14 days (range from 9 to 36 days). Ten out of 13 children are alive after a median follow-up of 13 months (range from 6 to 66 months).CONCLUSION: Median sternotomy is an adequate treatment modality for the resection of bilateral pulmonary metastases as a one-stage procedure. The combination of primary tumor resection with sternotomy should be considered as a treatment option. Complete resection of metastases of solid pediatric tumors should be aimed for in order to increase the survival of these patients.",
keywords = "Adolescent, Bone Neoplasms, Child, Child, Preschool, Female, Fibrosarcoma, Follow-Up Studies, Germany, Hepatoblastoma, Humans, Infant, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Male, Osteosarcoma, Pneumonectomy, Retrospective Studies, Sternum, Survival Rate, Treatment Outcome, Wilms Tumor",
author = "J{\"o}rg Fuchs and Guido Seitz and Verena Ellerkamp and Klaus Dietz and Axel Bosk and Ingo M{\"u}ller and Warmann, {Steven W} and Sch{\"a}fer, {J{\"u}rgen F}",
year = "2008",
month = dec,
doi = "10.1016/j.suronc.2008.05.004",
language = "English",
volume = "17",
pages = "323--30",
journal = "J SURG ONCOL",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors

AU - Fuchs, Jörg

AU - Seitz, Guido

AU - Ellerkamp, Verena

AU - Dietz, Klaus

AU - Bosk, Axel

AU - Müller, Ingo

AU - Warmann, Steven W

AU - Schäfer, Jürgen F

PY - 2008/12

Y1 - 2008/12

N2 - BACKGROUND: Radical surgical resection of metastases is an important prognostic factor for survival of patients suffering from solid pediatric tumors. The aim of this study is to evaluate the efficacy of median sternotomy as treatment option for the resection of multiple bilateral lung metastases in children with different tumor entities. Furthermore, the sensitivity of preoperative imaging (CT) was assessed by intraoperative findings.PATIENTS AND METHODS: Between 2002 and 2007, 13 children (4 with sarcoma, 4 with nephroblastoma, 5 with hepatoblastoma) underwent median sternotomy for resection of bilateral lung metastases after R0-resection of the primary tumor. In 6/13 cases, the sternotomy was combined with the primary tumor resection.RESULTS: Median patient age at the first operation was 5 years (range: 11 months to 17 years). The median total number of resected metastases per operation was 9 and ranged from 0 to 65. In 13/16 operations, the intraoperative number of metastases did not agree with the preoperative radiological work-up. Median hospital stay was 14 days (range from 9 to 36 days). Ten out of 13 children are alive after a median follow-up of 13 months (range from 6 to 66 months).CONCLUSION: Median sternotomy is an adequate treatment modality for the resection of bilateral pulmonary metastases as a one-stage procedure. The combination of primary tumor resection with sternotomy should be considered as a treatment option. Complete resection of metastases of solid pediatric tumors should be aimed for in order to increase the survival of these patients.

AB - BACKGROUND: Radical surgical resection of metastases is an important prognostic factor for survival of patients suffering from solid pediatric tumors. The aim of this study is to evaluate the efficacy of median sternotomy as treatment option for the resection of multiple bilateral lung metastases in children with different tumor entities. Furthermore, the sensitivity of preoperative imaging (CT) was assessed by intraoperative findings.PATIENTS AND METHODS: Between 2002 and 2007, 13 children (4 with sarcoma, 4 with nephroblastoma, 5 with hepatoblastoma) underwent median sternotomy for resection of bilateral lung metastases after R0-resection of the primary tumor. In 6/13 cases, the sternotomy was combined with the primary tumor resection.RESULTS: Median patient age at the first operation was 5 years (range: 11 months to 17 years). The median total number of resected metastases per operation was 9 and ranged from 0 to 65. In 13/16 operations, the intraoperative number of metastases did not agree with the preoperative radiological work-up. Median hospital stay was 14 days (range from 9 to 36 days). Ten out of 13 children are alive after a median follow-up of 13 months (range from 6 to 66 months).CONCLUSION: Median sternotomy is an adequate treatment modality for the resection of bilateral pulmonary metastases as a one-stage procedure. The combination of primary tumor resection with sternotomy should be considered as a treatment option. Complete resection of metastases of solid pediatric tumors should be aimed for in order to increase the survival of these patients.

KW - Adolescent

KW - Bone Neoplasms

KW - Child

KW - Child, Preschool

KW - Female

KW - Fibrosarcoma

KW - Follow-Up Studies

KW - Germany

KW - Hepatoblastoma

KW - Humans

KW - Infant

KW - Kidney Neoplasms

KW - Liver Neoplasms

KW - Lung Neoplasms

KW - Male

KW - Osteosarcoma

KW - Pneumonectomy

KW - Retrospective Studies

KW - Sternum

KW - Survival Rate

KW - Treatment Outcome

KW - Wilms Tumor

U2 - 10.1016/j.suronc.2008.05.004

DO - 10.1016/j.suronc.2008.05.004

M3 - SCORING: Journal article

C2 - 18586485

VL - 17

SP - 323

EP - 330

JO - J SURG ONCOL

JF - J SURG ONCOL

SN - 0022-4790

IS - 4

ER -