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Analysis of More than 16,000 Human Tumor and Normal Tissues Identifies Uroplakin 3B as a Useful Diagnostic Marker for Mesothelioma and Normal Mesothelial Cells

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Analysis of More than 16,000 Human Tumor and Normal Tissues Identifies Uroplakin 3B as a Useful Diagnostic Marker for Mesothelioma and Normal Mesothelial Cells. / Lennartz, Maximilian; Atug, Dennis; Dwertmann Rico, Sebastian; Reiswich, Viktor; Viehweger, Florian; Büscheck, Franziska; Kluth, Martina; Hube-Magg, Claudia; Hinsch, Andrea; Bernreuther, Christian; Sauter, Guido; Burandt, Eike; Marx, Andreas H; Krech, Till; Simon, Ronald; Minner, Sarah; Clauditz, Till S; Jacobsen, Frank; Lebok, Patrick; Gorbokon, Natalia; Möller, Katharina; Steurer, Stefan; Fraune, Christoph.

In: DIAGNOSTICS, Vol. 12, No. 10, 2516, 17.10.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lennartz, M, Atug, D, Dwertmann Rico, S, Reiswich, V, Viehweger, F, Büscheck, F, Kluth, M, Hube-Magg, C, Hinsch, A, Bernreuther, C, Sauter, G, Burandt, E, Marx, AH, Krech, T, Simon, R, Minner, S, Clauditz, TS, Jacobsen, F, Lebok, P, Gorbokon, N, Möller, K, Steurer, S & Fraune, C 2022, 'Analysis of More than 16,000 Human Tumor and Normal Tissues Identifies Uroplakin 3B as a Useful Diagnostic Marker for Mesothelioma and Normal Mesothelial Cells', DIAGNOSTICS, vol. 12, no. 10, 2516. https://doi.org/10.3390/diagnostics12102516

APA

Lennartz, M., Atug, D., Dwertmann Rico, S., Reiswich, V., Viehweger, F., Büscheck, F., Kluth, M., Hube-Magg, C., Hinsch, A., Bernreuther, C., Sauter, G., Burandt, E., Marx, A. H., Krech, T., Simon, R., Minner, S., Clauditz, T. S., Jacobsen, F., Lebok, P., ... Fraune, C. (2022). Analysis of More than 16,000 Human Tumor and Normal Tissues Identifies Uroplakin 3B as a Useful Diagnostic Marker for Mesothelioma and Normal Mesothelial Cells. DIAGNOSTICS, 12(10), [2516]. https://doi.org/10.3390/diagnostics12102516

Vancouver

Lennartz M, Atug D, Dwertmann Rico S, Reiswich V, Viehweger F, Büscheck F et al. Analysis of More than 16,000 Human Tumor and Normal Tissues Identifies Uroplakin 3B as a Useful Diagnostic Marker for Mesothelioma and Normal Mesothelial Cells. DIAGNOSTICS. 2022 Oct 17;12(10). 2516. https://doi.org/10.3390/diagnostics12102516

Bibtex

@article{f642822006304415b5d0ccf42a49663c,
title = "Analysis of More than 16,000 Human Tumor and Normal Tissues Identifies Uroplakin 3B as a Useful Diagnostic Marker for Mesothelioma and Normal Mesothelial Cells",
abstract = "Uroplakin 3B (Upk3b) is involved in stabilizing and strengthening the urothelial cell layer of the bladder. Based on RNA expression studies, Upk3b is expressed in a limited number of normal and tumor tissues. The potential use of Upk3b as a diagnostic or prognostic marker in tumor diagnosis has not yet been extensively investigated. A tissue microarray containing 17,693 samples from 151 different tumor types/subtypes and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. In normal tissues, Upk3b expression was largely limited to mesothelial cells, urothelial umbrella cells, and amnion cells. In tumor tissues, Upk3b was detectable in only 17 of 151 (11.3%) of tumor types. Upk3b expression was most frequent in mesotheliomas (82.1% of epithelioid and 30.8% of biphasic) and in urothelial tumors of the urinary bladder, where the positivity rate decreased from 61.9% in pTaG2 (low grade) to 58.0% in pTaG3 (high grade) and 14.6% in pT2-4 cancers. Among pT2-4 urothelial carcinomas, Upk3b staining was unrelated to tumor stage, lymph node status, and patient prognosis. Less commonly, Upk3b expression was also seen in Brenner tumors of the ovary (10.8%), as well as in four other subtypes of ovarian cancer (0.9-10.6%). Four additional tumor entities showed a weak to moderate Upk3b positivity in less than 5% of cases. In summary, Upk3b immunohistochemistry is a useful diagnostic tool for the distinction of mesotheliomas from other thoracic tumors and the visualization of normal mesothelial and umbrella cells.",
author = "Maximilian Lennartz and Dennis Atug and {Dwertmann Rico}, Sebastian and Viktor Reiswich and Florian Viehweger and Franziska B{\"u}scheck and Martina Kluth and Claudia Hube-Magg and Andrea Hinsch and Christian Bernreuther and Guido Sauter and Eike Burandt and Marx, {Andreas H} and Till Krech and Ronald Simon and Sarah Minner and Clauditz, {Till S} and Frank Jacobsen and Patrick Lebok and Natalia Gorbokon and Katharina M{\"o}ller and Stefan Steurer and Christoph Fraune",
year = "2022",
month = oct,
day = "17",
doi = "10.3390/diagnostics12102516",
language = "English",
volume = "12",
journal = "DIAGNOSTICS",
issn = "2075-4418",
publisher = "MDPI AG",
number = "10",

}

RIS

TY - JOUR

T1 - Analysis of More than 16,000 Human Tumor and Normal Tissues Identifies Uroplakin 3B as a Useful Diagnostic Marker for Mesothelioma and Normal Mesothelial Cells

AU - Lennartz, Maximilian

AU - Atug, Dennis

AU - Dwertmann Rico, Sebastian

AU - Reiswich, Viktor

AU - Viehweger, Florian

AU - Büscheck, Franziska

AU - Kluth, Martina

AU - Hube-Magg, Claudia

AU - Hinsch, Andrea

AU - Bernreuther, Christian

AU - Sauter, Guido

AU - Burandt, Eike

AU - Marx, Andreas H

AU - Krech, Till

AU - Simon, Ronald

AU - Minner, Sarah

AU - Clauditz, Till S

AU - Jacobsen, Frank

AU - Lebok, Patrick

AU - Gorbokon, Natalia

AU - Möller, Katharina

AU - Steurer, Stefan

AU - Fraune, Christoph

PY - 2022/10/17

Y1 - 2022/10/17

N2 - Uroplakin 3B (Upk3b) is involved in stabilizing and strengthening the urothelial cell layer of the bladder. Based on RNA expression studies, Upk3b is expressed in a limited number of normal and tumor tissues. The potential use of Upk3b as a diagnostic or prognostic marker in tumor diagnosis has not yet been extensively investigated. A tissue microarray containing 17,693 samples from 151 different tumor types/subtypes and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. In normal tissues, Upk3b expression was largely limited to mesothelial cells, urothelial umbrella cells, and amnion cells. In tumor tissues, Upk3b was detectable in only 17 of 151 (11.3%) of tumor types. Upk3b expression was most frequent in mesotheliomas (82.1% of epithelioid and 30.8% of biphasic) and in urothelial tumors of the urinary bladder, where the positivity rate decreased from 61.9% in pTaG2 (low grade) to 58.0% in pTaG3 (high grade) and 14.6% in pT2-4 cancers. Among pT2-4 urothelial carcinomas, Upk3b staining was unrelated to tumor stage, lymph node status, and patient prognosis. Less commonly, Upk3b expression was also seen in Brenner tumors of the ovary (10.8%), as well as in four other subtypes of ovarian cancer (0.9-10.6%). Four additional tumor entities showed a weak to moderate Upk3b positivity in less than 5% of cases. In summary, Upk3b immunohistochemistry is a useful diagnostic tool for the distinction of mesotheliomas from other thoracic tumors and the visualization of normal mesothelial and umbrella cells.

AB - Uroplakin 3B (Upk3b) is involved in stabilizing and strengthening the urothelial cell layer of the bladder. Based on RNA expression studies, Upk3b is expressed in a limited number of normal and tumor tissues. The potential use of Upk3b as a diagnostic or prognostic marker in tumor diagnosis has not yet been extensively investigated. A tissue microarray containing 17,693 samples from 151 different tumor types/subtypes and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. In normal tissues, Upk3b expression was largely limited to mesothelial cells, urothelial umbrella cells, and amnion cells. In tumor tissues, Upk3b was detectable in only 17 of 151 (11.3%) of tumor types. Upk3b expression was most frequent in mesotheliomas (82.1% of epithelioid and 30.8% of biphasic) and in urothelial tumors of the urinary bladder, where the positivity rate decreased from 61.9% in pTaG2 (low grade) to 58.0% in pTaG3 (high grade) and 14.6% in pT2-4 cancers. Among pT2-4 urothelial carcinomas, Upk3b staining was unrelated to tumor stage, lymph node status, and patient prognosis. Less commonly, Upk3b expression was also seen in Brenner tumors of the ovary (10.8%), as well as in four other subtypes of ovarian cancer (0.9-10.6%). Four additional tumor entities showed a weak to moderate Upk3b positivity in less than 5% of cases. In summary, Upk3b immunohistochemistry is a useful diagnostic tool for the distinction of mesotheliomas from other thoracic tumors and the visualization of normal mesothelial and umbrella cells.

U2 - 10.3390/diagnostics12102516

DO - 10.3390/diagnostics12102516

M3 - SCORING: Journal article

C2 - 36292206

VL - 12

JO - DIAGNOSTICS

JF - DIAGNOSTICS

SN - 2075-4418

IS - 10

M1 - 2516

ER -