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Analyses of sphingosine-1-phosphate in the context of transfusion: how much is in stored blood products and in patient blood?

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Analyses of sphingosine-1-phosphate in the context of transfusion: how much is in stored blood products and in patient blood? / Poppe, Annika; Moritz, Eileen; Geffken, Maria; Schreiber, Joerg; Greiwe, Gillis; Amschler, Katharina; Wruck, Marie-Louise; Schwedhelm, Edzard; Daum, Günter; Kluge, Stefan; Peine, Sven; Winkler, Martin Sebastian.

In: TRANSFUSION, Vol. 59, No. 10, 10.2019, p. 3071-3076.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Poppe, A, Moritz, E, Geffken, M, Schreiber, J, Greiwe, G, Amschler, K, Wruck, M-L, Schwedhelm, E, Daum, G, Kluge, S, Peine, S & Winkler, MS 2019, 'Analyses of sphingosine-1-phosphate in the context of transfusion: how much is in stored blood products and in patient blood?', TRANSFUSION, vol. 59, no. 10, pp. 3071-3076. https://doi.org/10.1111/trf.15494

APA

Poppe, A., Moritz, E., Geffken, M., Schreiber, J., Greiwe, G., Amschler, K., Wruck, M-L., Schwedhelm, E., Daum, G., Kluge, S., Peine, S., & Winkler, M. S. (2019). Analyses of sphingosine-1-phosphate in the context of transfusion: how much is in stored blood products and in patient blood? TRANSFUSION, 59(10), 3071-3076. https://doi.org/10.1111/trf.15494

Vancouver

Poppe A, Moritz E, Geffken M, Schreiber J, Greiwe G, Amschler K et al. Analyses of sphingosine-1-phosphate in the context of transfusion: how much is in stored blood products and in patient blood? TRANSFUSION. 2019 Oct;59(10):3071-3076. https://doi.org/10.1111/trf.15494

Bibtex

@article{7b6df4f4a16947feac55e576ba41ba98,
title = "Analyses of sphingosine-1-phosphate in the context of transfusion: how much is in stored blood products and in patient blood?",
abstract = "BACKGROUND: Sphingosine-1-phosphate (S1P) is a bloodborne lipid that regulates vascular tone and endothelial permeability. S1P concentrations are reduced in critically ill patients. As hematopoietic cells produce S1P, this study intends to investigate S1P concentrations in blood products during storage and in patient plasma after blood transfusion.STUDY DESIGN AND METHODS: S1P concentrations were measured in 83 red blood cell (RBC) units and 73 platelet concentrates (PCs) before and after storage. In addition, 26 critically ill patients who received one or two RBC units were recruited to measure S1P plasma levels before and three times within 24 hours after transfusion.RESULTS: The highest S1P concentrations were found in fresh PCs. S1P concentrations in PCs are reduced by 60% when stored at room temperature for 4 days, whereas in RBCs S1P concentrations remained stable when stored at 4°C within 35 days. S1P concentrations in PCs and RBCc were 2.5 to 6 times higher compared to patient plasma. Plasma S1P levels in critically ill patients, however, transiently decreased after transfusion of RBCs and recover to pretransfusion values within the following 24 hours.CONCLUSION: S1P concentrations in blood products are significantly higher compared to human plasma S1P levels, even though plasma S1P levels decreased after RBC transfusion in critically ill patients and reached pretransfusion values within 24 hours.",
author = "Annika Poppe and Eileen Moritz and Maria Geffken and Joerg Schreiber and Gillis Greiwe and Katharina Amschler and Marie-Louise Wruck and Edzard Schwedhelm and G{\"u}nter Daum and Stefan Kluge and Sven Peine and Winkler, {Martin Sebastian}",
note = "{\textcopyright} 2019 The Authors. Transfusion published by Wiley Periodicals, Inc. on behalf of AABB.",
year = "2019",
month = oct,
doi = "10.1111/trf.15494",
language = "English",
volume = "59",
pages = "3071--3076",
journal = "TRANSFUSION",
issn = "0041-1132",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - Analyses of sphingosine-1-phosphate in the context of transfusion: how much is in stored blood products and in patient blood?

AU - Poppe, Annika

AU - Moritz, Eileen

AU - Geffken, Maria

AU - Schreiber, Joerg

AU - Greiwe, Gillis

AU - Amschler, Katharina

AU - Wruck, Marie-Louise

AU - Schwedhelm, Edzard

AU - Daum, Günter

AU - Kluge, Stefan

AU - Peine, Sven

AU - Winkler, Martin Sebastian

N1 - © 2019 The Authors. Transfusion published by Wiley Periodicals, Inc. on behalf of AABB.

PY - 2019/10

Y1 - 2019/10

N2 - BACKGROUND: Sphingosine-1-phosphate (S1P) is a bloodborne lipid that regulates vascular tone and endothelial permeability. S1P concentrations are reduced in critically ill patients. As hematopoietic cells produce S1P, this study intends to investigate S1P concentrations in blood products during storage and in patient plasma after blood transfusion.STUDY DESIGN AND METHODS: S1P concentrations were measured in 83 red blood cell (RBC) units and 73 platelet concentrates (PCs) before and after storage. In addition, 26 critically ill patients who received one or two RBC units were recruited to measure S1P plasma levels before and three times within 24 hours after transfusion.RESULTS: The highest S1P concentrations were found in fresh PCs. S1P concentrations in PCs are reduced by 60% when stored at room temperature for 4 days, whereas in RBCs S1P concentrations remained stable when stored at 4°C within 35 days. S1P concentrations in PCs and RBCc were 2.5 to 6 times higher compared to patient plasma. Plasma S1P levels in critically ill patients, however, transiently decreased after transfusion of RBCs and recover to pretransfusion values within the following 24 hours.CONCLUSION: S1P concentrations in blood products are significantly higher compared to human plasma S1P levels, even though plasma S1P levels decreased after RBC transfusion in critically ill patients and reached pretransfusion values within 24 hours.

AB - BACKGROUND: Sphingosine-1-phosphate (S1P) is a bloodborne lipid that regulates vascular tone and endothelial permeability. S1P concentrations are reduced in critically ill patients. As hematopoietic cells produce S1P, this study intends to investigate S1P concentrations in blood products during storage and in patient plasma after blood transfusion.STUDY DESIGN AND METHODS: S1P concentrations were measured in 83 red blood cell (RBC) units and 73 platelet concentrates (PCs) before and after storage. In addition, 26 critically ill patients who received one or two RBC units were recruited to measure S1P plasma levels before and three times within 24 hours after transfusion.RESULTS: The highest S1P concentrations were found in fresh PCs. S1P concentrations in PCs are reduced by 60% when stored at room temperature for 4 days, whereas in RBCs S1P concentrations remained stable when stored at 4°C within 35 days. S1P concentrations in PCs and RBCc were 2.5 to 6 times higher compared to patient plasma. Plasma S1P levels in critically ill patients, however, transiently decreased after transfusion of RBCs and recover to pretransfusion values within the following 24 hours.CONCLUSION: S1P concentrations in blood products are significantly higher compared to human plasma S1P levels, even though plasma S1P levels decreased after RBC transfusion in critically ill patients and reached pretransfusion values within 24 hours.

U2 - 10.1111/trf.15494

DO - 10.1111/trf.15494

M3 - SCORING: Journal article

C2 - 31483505

VL - 59

SP - 3071

EP - 3076

JO - TRANSFUSION

JF - TRANSFUSION

SN - 0041-1132

IS - 10

ER -