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Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

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Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. / Brinkkoetter, Paul T; Bork, Tillmann; Salou, Sarah; Liang, Wei; Mizi, Athanasia; Özel, Cem; Koehler, Sybille; Hagmann, H Henning; Ising, Christina; Kuczkowski, Alexander; Schnyder, Svenia; Abed, Ahmed; Schermer, Bernhard; Benzing, Thomas; Kretz, Oliver; Puelles, Victor G; Lagies, Simon; Schlimpert, Manuel; Kammerer, Bernd; Handschin, Christoph; Schell, Christoph; Huber, Tobias B.

In: CELL REP, Vol. 27, No. 5, 30.04.2019, p. 1551-1566.e5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Brinkkoetter, PT, Bork, T, Salou, S, Liang, W, Mizi, A, Özel, C, Koehler, S, Hagmann, HH, Ising, C, Kuczkowski, A, Schnyder, S, Abed, A, Schermer, B, Benzing, T, Kretz, O, Puelles, VG, Lagies, S, Schlimpert, M, Kammerer, B, Handschin, C, Schell, C & Huber, TB 2019, 'Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics', CELL REP, vol. 27, no. 5, pp. 1551-1566.e5. https://doi.org/10.1016/j.celrep.2019.04.012

APA

Brinkkoetter, P. T., Bork, T., Salou, S., Liang, W., Mizi, A., Özel, C., Koehler, S., Hagmann, H. H., Ising, C., Kuczkowski, A., Schnyder, S., Abed, A., Schermer, B., Benzing, T., Kretz, O., Puelles, V. G., Lagies, S., Schlimpert, M., Kammerer, B., ... Huber, T. B. (2019). Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. CELL REP, 27(5), 1551-1566.e5. https://doi.org/10.1016/j.celrep.2019.04.012

Vancouver

Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C et al. Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. CELL REP. 2019 Apr 30;27(5):1551-1566.e5. https://doi.org/10.1016/j.celrep.2019.04.012

Bibtex

@article{86841456bffe49a0bd6d1ef26d4ff778,
title = "Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics",
abstract = "The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of glomerular podocytes. Combining functional measurements of oxygen consumption rates, glomerular metabolite analysis, and determination of mitochondrial density of podocytes in vivo, we demonstrate that anaerobic glycolysis and fermentation of glucose to lactate represent the key energy source of podocytes. Under physiological conditions, we could detect neither a developmental nor late-onset pathological phenotype in podocytes with impaired mitochondrial biogenesis machinery, defective mitochondrial fusion-fission apparatus, or reduced mtDNA stability and transcription caused by podocyte-specific deletion of Pgc-1α, Drp1, or Tfam, respectively. Anaerobic glycolysis represents the predominant metabolic pathway of podocytes. These findings offer a strategy to therapeutically interfere with the enhanced podocyte metabolism in various progressive kidney diseases, such as diabetic nephropathy or focal segmental glomerulosclerosis (FSGS).",
author = "Brinkkoetter, {Paul T} and Tillmann Bork and Sarah Salou and Wei Liang and Athanasia Mizi and Cem {\"O}zel and Sybille Koehler and Hagmann, {H Henning} and Christina Ising and Alexander Kuczkowski and Svenia Schnyder and Ahmed Abed and Bernhard Schermer and Thomas Benzing and Oliver Kretz and Puelles, {Victor G} and Simon Lagies and Manuel Schlimpert and Bernd Kammerer and Christoph Handschin and Christoph Schell and Huber, {Tobias B}",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = apr,
day = "30",
doi = "10.1016/j.celrep.2019.04.012",
language = "English",
volume = "27",
pages = "1551--1566.e5",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

AU - Brinkkoetter, Paul T

AU - Bork, Tillmann

AU - Salou, Sarah

AU - Liang, Wei

AU - Mizi, Athanasia

AU - Özel, Cem

AU - Koehler, Sybille

AU - Hagmann, H Henning

AU - Ising, Christina

AU - Kuczkowski, Alexander

AU - Schnyder, Svenia

AU - Abed, Ahmed

AU - Schermer, Bernhard

AU - Benzing, Thomas

AU - Kretz, Oliver

AU - Puelles, Victor G

AU - Lagies, Simon

AU - Schlimpert, Manuel

AU - Kammerer, Bernd

AU - Handschin, Christoph

AU - Schell, Christoph

AU - Huber, Tobias B

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2019/4/30

Y1 - 2019/4/30

N2 - The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of glomerular podocytes. Combining functional measurements of oxygen consumption rates, glomerular metabolite analysis, and determination of mitochondrial density of podocytes in vivo, we demonstrate that anaerobic glycolysis and fermentation of glucose to lactate represent the key energy source of podocytes. Under physiological conditions, we could detect neither a developmental nor late-onset pathological phenotype in podocytes with impaired mitochondrial biogenesis machinery, defective mitochondrial fusion-fission apparatus, or reduced mtDNA stability and transcription caused by podocyte-specific deletion of Pgc-1α, Drp1, or Tfam, respectively. Anaerobic glycolysis represents the predominant metabolic pathway of podocytes. These findings offer a strategy to therapeutically interfere with the enhanced podocyte metabolism in various progressive kidney diseases, such as diabetic nephropathy or focal segmental glomerulosclerosis (FSGS).

AB - The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of glomerular podocytes. Combining functional measurements of oxygen consumption rates, glomerular metabolite analysis, and determination of mitochondrial density of podocytes in vivo, we demonstrate that anaerobic glycolysis and fermentation of glucose to lactate represent the key energy source of podocytes. Under physiological conditions, we could detect neither a developmental nor late-onset pathological phenotype in podocytes with impaired mitochondrial biogenesis machinery, defective mitochondrial fusion-fission apparatus, or reduced mtDNA stability and transcription caused by podocyte-specific deletion of Pgc-1α, Drp1, or Tfam, respectively. Anaerobic glycolysis represents the predominant metabolic pathway of podocytes. These findings offer a strategy to therapeutically interfere with the enhanced podocyte metabolism in various progressive kidney diseases, such as diabetic nephropathy or focal segmental glomerulosclerosis (FSGS).

U2 - 10.1016/j.celrep.2019.04.012

DO - 10.1016/j.celrep.2019.04.012

M3 - SCORING: Journal article

C2 - 31042480

VL - 27

SP - 1551-1566.e5

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 5

ER -