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An introduction to bone tissue engineering

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An introduction to bone tissue engineering. / Perić Kačarević, Željka; Rider, Patrick; Alkildani, Said; Retnasingh, Sujith; Pejakić, Marija; Schnettler, Reinhard; Gosau, Martin; Smeets, Ralf; Jung, Ole; Barbeck, Mike.

In: INT J ARTIF ORGANS, Vol. 43, No. 2, 02.2020, p. 69-86.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Perić Kačarević, Ž, Rider, P, Alkildani, S, Retnasingh, S, Pejakić, M, Schnettler, R, Gosau, M, Smeets, R, Jung, O & Barbeck, M 2020, 'An introduction to bone tissue engineering', INT J ARTIF ORGANS, vol. 43, no. 2, pp. 69-86. https://doi.org/10.1177/0391398819876286

APA

Perić Kačarević, Ž., Rider, P., Alkildani, S., Retnasingh, S., Pejakić, M., Schnettler, R., Gosau, M., Smeets, R., Jung, O., & Barbeck, M. (2020). An introduction to bone tissue engineering. INT J ARTIF ORGANS, 43(2), 69-86. https://doi.org/10.1177/0391398819876286

Vancouver

Perić Kačarević Ž, Rider P, Alkildani S, Retnasingh S, Pejakić M, Schnettler R et al. An introduction to bone tissue engineering. INT J ARTIF ORGANS. 2020 Feb;43(2):69-86. https://doi.org/10.1177/0391398819876286

Bibtex

@article{d4f51270ad5043429d1c7d85304becea,
title = "An introduction to bone tissue engineering",
abstract = "Bone tissue has the capability to regenerate itself; however, defects of a critical size prevent the bone from regenerating and require additional support. To aid regeneration, bone scaffolds created out of autologous or allograft bone can be used, yet these produce problems such as fast degradation rates, reduced bioactivity, donor site morbidity or the risk of pathogen transmission. The development of bone tissue engineering has been used to create functional alternatives to regenerate bone. This can be achieved by producing bone tissue scaffolds that induce osteoconduction and integration, provide mechanical stability, and either integrate into the bone structure or degrade and are excreted by the body. A range of different biomaterials have been used to this end, each with their own advantages and disadvantages. This review will introduce the requirements of bone tissue engineering, beginning with the regeneration process of bone before exploring the requirements of bone tissue scaffolds. Aspects covered include the manufacturing process as well as the different materials used and the incorporation of bioactive molecules, growth factors and cells.",
keywords = "Biocompatible Materials/classification, Bone Regeneration/physiology, Humans, Osseointegration/physiology, Tissue Engineering/methods, Tissue Scaffolds",
author = "{Peri{\'c} Ka{\v c}arevi{\'c}}, {\v Z}eljka and Patrick Rider and Said Alkildani and Sujith Retnasingh and Marija Pejaki{\'c} and Reinhard Schnettler and Martin Gosau and Ralf Smeets and Ole Jung and Mike Barbeck",
year = "2020",
month = feb,
doi = "10.1177/0391398819876286",
language = "English",
volume = "43",
pages = "69--86",
journal = "INT J ARTIF ORGANS",
issn = "0391-3988",
publisher = "Wichtig Publishing",
number = "2",

}

RIS

TY - JOUR

T1 - An introduction to bone tissue engineering

AU - Perić Kačarević, Željka

AU - Rider, Patrick

AU - Alkildani, Said

AU - Retnasingh, Sujith

AU - Pejakić, Marija

AU - Schnettler, Reinhard

AU - Gosau, Martin

AU - Smeets, Ralf

AU - Jung, Ole

AU - Barbeck, Mike

PY - 2020/2

Y1 - 2020/2

N2 - Bone tissue has the capability to regenerate itself; however, defects of a critical size prevent the bone from regenerating and require additional support. To aid regeneration, bone scaffolds created out of autologous or allograft bone can be used, yet these produce problems such as fast degradation rates, reduced bioactivity, donor site morbidity or the risk of pathogen transmission. The development of bone tissue engineering has been used to create functional alternatives to regenerate bone. This can be achieved by producing bone tissue scaffolds that induce osteoconduction and integration, provide mechanical stability, and either integrate into the bone structure or degrade and are excreted by the body. A range of different biomaterials have been used to this end, each with their own advantages and disadvantages. This review will introduce the requirements of bone tissue engineering, beginning with the regeneration process of bone before exploring the requirements of bone tissue scaffolds. Aspects covered include the manufacturing process as well as the different materials used and the incorporation of bioactive molecules, growth factors and cells.

AB - Bone tissue has the capability to regenerate itself; however, defects of a critical size prevent the bone from regenerating and require additional support. To aid regeneration, bone scaffolds created out of autologous or allograft bone can be used, yet these produce problems such as fast degradation rates, reduced bioactivity, donor site morbidity or the risk of pathogen transmission. The development of bone tissue engineering has been used to create functional alternatives to regenerate bone. This can be achieved by producing bone tissue scaffolds that induce osteoconduction and integration, provide mechanical stability, and either integrate into the bone structure or degrade and are excreted by the body. A range of different biomaterials have been used to this end, each with their own advantages and disadvantages. This review will introduce the requirements of bone tissue engineering, beginning with the regeneration process of bone before exploring the requirements of bone tissue scaffolds. Aspects covered include the manufacturing process as well as the different materials used and the incorporation of bioactive molecules, growth factors and cells.

KW - Biocompatible Materials/classification

KW - Bone Regeneration/physiology

KW - Humans

KW - Osseointegration/physiology

KW - Tissue Engineering/methods

KW - Tissue Scaffolds

U2 - 10.1177/0391398819876286

DO - 10.1177/0391398819876286

M3 - SCORING: Review article

C2 - 31544576

VL - 43

SP - 69

EP - 86

JO - INT J ARTIF ORGANS

JF - INT J ARTIF ORGANS

SN - 0391-3988

IS - 2

ER -