An evaluation of R2 as an inadequate measure for nonlinear models in pharmacological and biochemical research: a Monte Carlo approach.

  • Andrej-Nikolai Spiess
  • Natalie Neumeyer

Abstract

It is long known within the mathematical literature that the coefficient of determination R(2) is an inadequate measure for the goodness of fit in nonlinear models. Nevertheless, it is still frequently used within pharmacological and biochemical literature for the analysis and interpretation of nonlinear fitting to data.

Bibliographical data

Original languageEnglish
ISSN2050-6511
Publication statusPublished - 2010
pubmed 20529254