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An elevated plus-maze in mixed reality for studying human anxiety-related behavior

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An elevated plus-maze in mixed reality for studying human anxiety-related behavior. / Biedermann, Sarah V; Biedermann, Daniel; Wenzlaff, Frederike; Kurjak, Tim; Nouri, Sawis; Auer, Matthias; Wiedemann, Klaus; Briken, Peer; Haaker, Jan; Lonsdorf, Tina Barbara; Fuß, Johannes.

In: BMC BIOL, Vol. 15, No. 125, 21.12.2017, p. 1-13.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Biedermann, SV, Biedermann, D, Wenzlaff, F, Kurjak, T, Nouri, S, Auer, M, Wiedemann, K, Briken, P, Haaker, J, Lonsdorf, TB & Fuß, J 2017, 'An elevated plus-maze in mixed reality for studying human anxiety-related behavior', BMC BIOL, vol. 15, no. 125, pp. 1-13. https://doi.org/10.1186/s12915-017-0463-6

APA

Biedermann, S. V., Biedermann, D., Wenzlaff, F., Kurjak, T., Nouri, S., Auer, M., Wiedemann, K., Briken, P., Haaker, J., Lonsdorf, T. B., & Fuß, J. (2017). An elevated plus-maze in mixed reality for studying human anxiety-related behavior. BMC BIOL, 15(125), 1-13. https://doi.org/10.1186/s12915-017-0463-6

Vancouver

Biedermann SV, Biedermann D, Wenzlaff F, Kurjak T, Nouri S, Auer M et al. An elevated plus-maze in mixed reality for studying human anxiety-related behavior. BMC BIOL. 2017 Dec 21;15(125):1-13. https://doi.org/10.1186/s12915-017-0463-6

Bibtex

@article{f5b1d76e6e4d4d92836aaaa4fd21c95b,
title = "An elevated plus-maze in mixed reality for studying human anxiety-related behavior",
abstract = "BACKGROUND: A dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance behavior in rodents.METHODS: Here, we translated the EPM to humans using mixed reality through a combination of virtual and real-world elements. In two validation studies, we observed participants' anxiety on a behavioral, physiological, and subjective level.RESULTS: Participants reported higher anxiety on open arms, avoided open arms, and showed an activation of endogenous stress systems. Participants' with high anxiety exhibited higher avoidance. Moreover, open arm avoidance was moderately predicted by participants' acrophobia and sensation seeking, with opposing influences. In a randomized, double blind, placebo controlled experiment, GABAergic stimulation decreased avoidance of open arms while alpha-2-adrenergic antagonism increased avoidance.CONCLUSION: These findings demonstrate cross-species validity of open arm avoidance as a translational measure of anxiety. We thus introduce the first ecologically valid assay to track actual human approach-avoidance behavior under laboratory conditions.",
keywords = "Adult, Anxiety/diagnosis, Avoidance Learning/drug effects, Female, GABA Agents/pharmacology, Humans, Male, Maze Learning, Middle Aged, Virtual Reality",
author = "Biedermann, {Sarah V} and Daniel Biedermann and Frederike Wenzlaff and Tim Kurjak and Sawis Nouri and Matthias Auer and Klaus Wiedemann and Peer Briken and Jan Haaker and Lonsdorf, {Tina Barbara} and Johannes Fu{\ss}",
year = "2017",
month = dec,
day = "21",
doi = "10.1186/s12915-017-0463-6",
language = "English",
volume = "15",
pages = "1--13",
journal = "BMC BIOL",
issn = "1741-7007",
publisher = "BioMed Central Ltd.",
number = "125",

}

RIS

TY - JOUR

T1 - An elevated plus-maze in mixed reality for studying human anxiety-related behavior

AU - Biedermann, Sarah V

AU - Biedermann, Daniel

AU - Wenzlaff, Frederike

AU - Kurjak, Tim

AU - Nouri, Sawis

AU - Auer, Matthias

AU - Wiedemann, Klaus

AU - Briken, Peer

AU - Haaker, Jan

AU - Lonsdorf, Tina Barbara

AU - Fuß, Johannes

PY - 2017/12/21

Y1 - 2017/12/21

N2 - BACKGROUND: A dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance behavior in rodents.METHODS: Here, we translated the EPM to humans using mixed reality through a combination of virtual and real-world elements. In two validation studies, we observed participants' anxiety on a behavioral, physiological, and subjective level.RESULTS: Participants reported higher anxiety on open arms, avoided open arms, and showed an activation of endogenous stress systems. Participants' with high anxiety exhibited higher avoidance. Moreover, open arm avoidance was moderately predicted by participants' acrophobia and sensation seeking, with opposing influences. In a randomized, double blind, placebo controlled experiment, GABAergic stimulation decreased avoidance of open arms while alpha-2-adrenergic antagonism increased avoidance.CONCLUSION: These findings demonstrate cross-species validity of open arm avoidance as a translational measure of anxiety. We thus introduce the first ecologically valid assay to track actual human approach-avoidance behavior under laboratory conditions.

AB - BACKGROUND: A dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance behavior in rodents.METHODS: Here, we translated the EPM to humans using mixed reality through a combination of virtual and real-world elements. In two validation studies, we observed participants' anxiety on a behavioral, physiological, and subjective level.RESULTS: Participants reported higher anxiety on open arms, avoided open arms, and showed an activation of endogenous stress systems. Participants' with high anxiety exhibited higher avoidance. Moreover, open arm avoidance was moderately predicted by participants' acrophobia and sensation seeking, with opposing influences. In a randomized, double blind, placebo controlled experiment, GABAergic stimulation decreased avoidance of open arms while alpha-2-adrenergic antagonism increased avoidance.CONCLUSION: These findings demonstrate cross-species validity of open arm avoidance as a translational measure of anxiety. We thus introduce the first ecologically valid assay to track actual human approach-avoidance behavior under laboratory conditions.

KW - Adult

KW - Anxiety/diagnosis

KW - Avoidance Learning/drug effects

KW - Female

KW - GABA Agents/pharmacology

KW - Humans

KW - Male

KW - Maze Learning

KW - Middle Aged

KW - Virtual Reality

U2 - 10.1186/s12915-017-0463-6

DO - 10.1186/s12915-017-0463-6

M3 - SCORING: Journal article

C2 - 29268740

VL - 15

SP - 1

EP - 13

JO - BMC BIOL

JF - BMC BIOL

SN - 1741-7007

IS - 125

ER -