An aggressive systemic juvenile xanthogranuloma clonally related to a preceding T-cell acute lymphoblastic leukemia.
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An aggressive systemic juvenile xanthogranuloma clonally related to a preceding T-cell acute lymphoblastic leukemia. / Perez-Becker, Ruy; Szczepanowski, Monika; Leuschner, Ivo; Janka-Schaub, Gritta; Gokel, Michael; Imschweiler, Thomas; Völpel, Sigrid; Niehues, Tim; Klapper, Wolfram.
In: PEDIATR BLOOD CANCER, Vol. 56, No. 5, 5, 2011, p. 859-862.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - An aggressive systemic juvenile xanthogranuloma clonally related to a preceding T-cell acute lymphoblastic leukemia.
AU - Perez-Becker, Ruy
AU - Szczepanowski, Monika
AU - Leuschner, Ivo
AU - Janka-Schaub, Gritta
AU - Gokel, Michael
AU - Imschweiler, Thomas
AU - Völpel, Sigrid
AU - Niehues, Tim
AU - Klapper, Wolfram
PY - 2011
Y1 - 2011
N2 - Juvenile xanthogranuloma (JXG) is a disorder of disputed origin thought to be related to the dermal/interstitial macrophage. A 5-year-old female presented with an aggressive systemic JXG that developed 5 months after the diagnosis of T-cell acute lymphoblastic leukemia (T-ALL). Examination of the T-cell receptor gamma (TCR- ) rearrangement in T-ALL blasts, JXG infiltrated lymph node biopsies and micro-dissected JXG histiocytes revealed an identical bi-allelic TCR- rearrangement in all samples, thus providing evidence for a clonal relationship between T-ALL and JXG in this case.
AB - Juvenile xanthogranuloma (JXG) is a disorder of disputed origin thought to be related to the dermal/interstitial macrophage. A 5-year-old female presented with an aggressive systemic JXG that developed 5 months after the diagnosis of T-cell acute lymphoblastic leukemia (T-ALL). Examination of the T-cell receptor gamma (TCR- ) rearrangement in T-ALL blasts, JXG infiltrated lymph node biopsies and micro-dissected JXG histiocytes revealed an identical bi-allelic TCR- rearrangement in all samples, thus providing evidence for a clonal relationship between T-ALL and JXG in this case.
M3 - SCORING: Zeitschriftenaufsatz
VL - 56
SP - 859
EP - 862
JO - PEDIATR BLOOD CANCER
JF - PEDIATR BLOOD CANCER
SN - 1545-5009
IS - 5
M1 - 5
ER -