Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma.
Standard
Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma. / Kontush, A; Berndt, C; Weber, W; Akopyan, V; Arlt, Sönke; Schippling, Sven; Beisiegel, U.
In: FREE RADICAL BIO MED, Vol. 30, No. 1, 1, 2001, p. 119-128.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma.
AU - Kontush, A
AU - Berndt, C
AU - Weber, W
AU - Akopyan, V
AU - Arlt, Sönke
AU - Schippling, Sven
AU - Beisiegel, U
PY - 2001
Y1 - 2001
N2 - Amyloid-beta (Abeta) peptide, a major constituent of senile plaques and a hallmark of Alzheimer's disease (AD), is normally secreted by neurons and can be found in low concentrations in cerebrospinal fluid (CSF) and plasma, where it is associated with lipoproteins. However, the physiological role of Abeta secretion remains unknown. Here we show that at the concentrations measured in biological fluids (0.1-1.0 nM), Abeta(1-40) strongly inhibits autooxidation of CSF lipoproteins and plasma low density lipoprotein (LDL). At higher concentrations of the peptide its antioxidant action was abolished. Abeta(1-40) also inhibited copper-catalyzed LDL oxidation when added in molar excess of copper, but did not influence oxidation induced by an azo-initiator. Other Abeta peptides also possessed antioxidant activity in the order Abeta(1-40) > Abeta(1-42) > Abeta(25-35), whereas Abeta(35-25) was inactive. These data suggest that Abeta(1-40) may act as a physiological antioxidant in CSF and plasma lipoproteins, functioning by chelating transition metal ions.
AB - Amyloid-beta (Abeta) peptide, a major constituent of senile plaques and a hallmark of Alzheimer's disease (AD), is normally secreted by neurons and can be found in low concentrations in cerebrospinal fluid (CSF) and plasma, where it is associated with lipoproteins. However, the physiological role of Abeta secretion remains unknown. Here we show that at the concentrations measured in biological fluids (0.1-1.0 nM), Abeta(1-40) strongly inhibits autooxidation of CSF lipoproteins and plasma low density lipoprotein (LDL). At higher concentrations of the peptide its antioxidant action was abolished. Abeta(1-40) also inhibited copper-catalyzed LDL oxidation when added in molar excess of copper, but did not influence oxidation induced by an azo-initiator. Other Abeta peptides also possessed antioxidant activity in the order Abeta(1-40) > Abeta(1-42) > Abeta(25-35), whereas Abeta(35-25) was inactive. These data suggest that Abeta(1-40) may act as a physiological antioxidant in CSF and plasma lipoproteins, functioning by chelating transition metal ions.
M3 - SCORING: Zeitschriftenaufsatz
VL - 30
SP - 119
EP - 128
JO - FREE RADICAL BIO MED
JF - FREE RADICAL BIO MED
SN - 0891-5849
IS - 1
M1 - 1
ER -
