Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing.
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Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing. / Lewczuk, P; Kornhuber, J; Vanmechelen, E; Peters, O; Heuser, I; Maier, W; Jessen, F; Bürger, K; Hampel, H; Frölich, L; Henn, F; Falkai, P; Rüther, E; Jahn, Holger; Luckhaus, Ch; Perneczky, R; Schmidtke, K; Schröder, J; Kessler, H; Pantel, J; Gertz, H-J; Vanderstichele, H; de Meyer, G; Shapiro, F; Wolf, S; Bibl, M; Wiltfang, J.
In: EXP NEUROL, 2009.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing.
AU - Lewczuk, P
AU - Kornhuber, J
AU - Vanmechelen, E
AU - Peters, O
AU - Heuser, I
AU - Maier, W
AU - Jessen, F
AU - Bürger, K
AU - Hampel, H
AU - Frölich, L
AU - Henn, F
AU - Falkai, P
AU - Rüther, E
AU - Jahn, Holger
AU - Luckhaus, Ch
AU - Perneczky, R
AU - Schmidtke, K
AU - Schröder, J
AU - Kessler, H
AU - Pantel, J
AU - Gertz, H-J
AU - Vanderstichele, H
AU - de Meyer, G
AU - Shapiro, F
AU - Wolf, S
AU - Bibl, M
AU - Wiltfang, J
PY - 2009
Y1 - 2009
N2 - We measured concentrations of Abeta peptides 1-42 and 1-40, and their ratio in plasma of patients carefully categorized clinically and neurochemically as having AD or other dementias with a newly commercially available multiplexing assay, characterized by reasonable laboratory performance (intra-assay imprecision in the range of 1.3-3.8% for Abeta1-42, and 1.8-4.1% for Abeta1-40, inter-assay imprecision for Abeta1-42, Abeta1-40, and Abeta1-42/Abeta1-40 concentration ratio in the range of 2.3-11.5%, 2.2-10.4% and 4.2-9.7%, respectively). Patients with AD or mild cognitive impairment of AD type (MCI-AD) whose clinical diagnosis was supported with CSF biomarkers (n=193) had significantly lower Abeta1-42 plasma concentrations (p
AB - We measured concentrations of Abeta peptides 1-42 and 1-40, and their ratio in plasma of patients carefully categorized clinically and neurochemically as having AD or other dementias with a newly commercially available multiplexing assay, characterized by reasonable laboratory performance (intra-assay imprecision in the range of 1.3-3.8% for Abeta1-42, and 1.8-4.1% for Abeta1-40, inter-assay imprecision for Abeta1-42, Abeta1-40, and Abeta1-42/Abeta1-40 concentration ratio in the range of 2.3-11.5%, 2.2-10.4% and 4.2-9.7%, respectively). Patients with AD or mild cognitive impairment of AD type (MCI-AD) whose clinical diagnosis was supported with CSF biomarkers (n=193) had significantly lower Abeta1-42 plasma concentrations (p
M3 - SCORING: Zeitschriftenaufsatz
JO - EXP NEUROL
JF - EXP NEUROL
SN - 0014-4886
ER -