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Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load.

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Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load. / Wiltfang, Jens; Esselmann, Hermann; Bibl, Mirko; Hüll, Michael; Hampel, Harald; Kessler, Holger; Frölich, Lutz; Schröder, Johannes; Peters, Oliver; Jessen, Frank; Luckhaus, Christian; Perneczky, Robert; Jahn, Holger; Fiszer, Magdalena; Maler, Juan Manuel; Zimmermann, Rüdiger; Bruckmoser, Ralf; Kornhuber, Johannes; Lewczuk, Piotr.

In: J NEUROCHEM, Vol. 101, No. 4, 4, 2007, p. 1053-1059.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wiltfang, J, Esselmann, H, Bibl, M, Hüll, M, Hampel, H, Kessler, H, Frölich, L, Schröder, J, Peters, O, Jessen, F, Luckhaus, C, Perneczky, R, Jahn, H, Fiszer, M, Maler, JM, Zimmermann, R, Bruckmoser, R, Kornhuber, J & Lewczuk, P 2007, 'Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load.', J NEUROCHEM, vol. 101, no. 4, 4, pp. 1053-1059. <http://www.ncbi.nlm.nih.gov/pubmed/17254013?dopt=Citation>

APA

Wiltfang, J., Esselmann, H., Bibl, M., Hüll, M., Hampel, H., Kessler, H., Frölich, L., Schröder, J., Peters, O., Jessen, F., Luckhaus, C., Perneczky, R., Jahn, H., Fiszer, M., Maler, J. M., Zimmermann, R., Bruckmoser, R., Kornhuber, J., & Lewczuk, P. (2007). Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load. J NEUROCHEM, 101(4), 1053-1059. [4]. http://www.ncbi.nlm.nih.gov/pubmed/17254013?dopt=Citation

Vancouver

Wiltfang J, Esselmann H, Bibl M, Hüll M, Hampel H, Kessler H et al. Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load. J NEUROCHEM. 2007;101(4):1053-1059. 4.

Bibtex

@article{d49b79c04d9240dfa13ca038457e913c,
title = "Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load.",
abstract = "Neurochemical dementia diagnostics (NDD) can significantly improve the clinically based categorization of patients with early dementia disorders, and the cerebrospinal fluid (CSF) concentrations of amyloid beta peptides ending at the amino acid position of 42 (A beta x-42 and A beta 1-42) are widely accepted biomarkers of Alzheimer's disease (AD). However, in subjects with constitutively high- or low-CSF concentrations of total A beta peptides (tA beta), the NDD interpretation might lead to erroneous conclusions as these biomarkers seem to correlate better with the total A beta load than with the pathological status of a given patient in such cases. In this multicenter study, we found significantly increased CSF concentrations of phosphorylated Tau (pTau181) and total Tau in the group of subjects with high CSF A beta x-40 concentrations and decreased A beta x-42/x-40 concentration ratio compared with the group of subjects with low CSF A beta x-40 and normal A beta ratio (p",
author = "Jens Wiltfang and Hermann Esselmann and Mirko Bibl and Michael H{\"u}ll and Harald Hampel and Holger Kessler and Lutz Fr{\"o}lich and Johannes Schr{\"o}der and Oliver Peters and Frank Jessen and Christian Luckhaus and Robert Perneczky and Holger Jahn and Magdalena Fiszer and Maler, {Juan Manuel} and R{\"u}diger Zimmermann and Ralf Bruckmoser and Johannes Kornhuber and Piotr Lewczuk",
year = "2007",
language = "Deutsch",
volume = "101",
pages = "1053--1059",
journal = "J NEUROCHEM",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load.

AU - Wiltfang, Jens

AU - Esselmann, Hermann

AU - Bibl, Mirko

AU - Hüll, Michael

AU - Hampel, Harald

AU - Kessler, Holger

AU - Frölich, Lutz

AU - Schröder, Johannes

AU - Peters, Oliver

AU - Jessen, Frank

AU - Luckhaus, Christian

AU - Perneczky, Robert

AU - Jahn, Holger

AU - Fiszer, Magdalena

AU - Maler, Juan Manuel

AU - Zimmermann, Rüdiger

AU - Bruckmoser, Ralf

AU - Kornhuber, Johannes

AU - Lewczuk, Piotr

PY - 2007

Y1 - 2007

N2 - Neurochemical dementia diagnostics (NDD) can significantly improve the clinically based categorization of patients with early dementia disorders, and the cerebrospinal fluid (CSF) concentrations of amyloid beta peptides ending at the amino acid position of 42 (A beta x-42 and A beta 1-42) are widely accepted biomarkers of Alzheimer's disease (AD). However, in subjects with constitutively high- or low-CSF concentrations of total A beta peptides (tA beta), the NDD interpretation might lead to erroneous conclusions as these biomarkers seem to correlate better with the total A beta load than with the pathological status of a given patient in such cases. In this multicenter study, we found significantly increased CSF concentrations of phosphorylated Tau (pTau181) and total Tau in the group of subjects with high CSF A beta x-40 concentrations and decreased A beta x-42/x-40 concentration ratio compared with the group of subjects with low CSF A beta x-40 and normal A beta ratio (p

AB - Neurochemical dementia diagnostics (NDD) can significantly improve the clinically based categorization of patients with early dementia disorders, and the cerebrospinal fluid (CSF) concentrations of amyloid beta peptides ending at the amino acid position of 42 (A beta x-42 and A beta 1-42) are widely accepted biomarkers of Alzheimer's disease (AD). However, in subjects with constitutively high- or low-CSF concentrations of total A beta peptides (tA beta), the NDD interpretation might lead to erroneous conclusions as these biomarkers seem to correlate better with the total A beta load than with the pathological status of a given patient in such cases. In this multicenter study, we found significantly increased CSF concentrations of phosphorylated Tau (pTau181) and total Tau in the group of subjects with high CSF A beta x-40 concentrations and decreased A beta x-42/x-40 concentration ratio compared with the group of subjects with low CSF A beta x-40 and normal A beta ratio (p

M3 - SCORING: Zeitschriftenaufsatz

VL - 101

SP - 1053

EP - 1059

JO - J NEUROCHEM

JF - J NEUROCHEM

SN - 0022-3042

IS - 4

M1 - 4

ER -