Amygdala-dependent fear conditioning in humans is modulated by the BDNFval66met polymorphism
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Amygdala-dependent fear conditioning in humans is modulated by the BDNFval66met polymorphism. / Lonsdorf, Tina B; Weike, Almut I; Golkar, Armita; Schalling, Martin; Hamm, Alfons O; Ohman, Arne.
In: BEHAV NEUROSCI, Vol. 124, No. 1, 01.02.2010, p. 9-15.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Amygdala-dependent fear conditioning in humans is modulated by the BDNFval66met polymorphism
AU - Lonsdorf, Tina B
AU - Weike, Almut I
AU - Golkar, Armita
AU - Schalling, Martin
AU - Hamm, Alfons O
AU - Ohman, Arne
N1 - (c) 2009 APA, all rights reserved.
PY - 2010/2/1
Y1 - 2010/2/1
N2 - The brain-derived neurotrophic factor (BDNF) is critically involved in neuroplasticity, as well as the acquisition, consolidation, and retention of hippocampal- and amygdala-dependent learning. A common functional A-->G single nucleotide polymorphism (BDNFval66met) in the prodomain of the human BDNF gene is associated with abnormal intracellular trafficking and reduced activity-dependent BDNF release. We studied the effect of BDNFval66met in an aversive differential fear conditioning, and a delayed extinction paradigm in 57 healthy participants. Pictures of male faces were used as stimuli and fear learning was quantified by fear potentiated startle (FPS) and skin conductance responses (SCR). Aware BDNF met-carriers show a deficit in amygdala-dependent fear conditioning as indicated by an absence of FPS responses in the last acquisition block. This deficit was maintained in the first block of extinction. No genotype differences were found in conditioned SCR discrimination. These data provide evidence for the involvement of BDNF signaling in human amygdala-dependent learning. We suggest that the BDNF met-allele may have a protective effect for the development of affective pathologies that may be mediated via reduced synaptic plasticity induced by negative experience.
AB - The brain-derived neurotrophic factor (BDNF) is critically involved in neuroplasticity, as well as the acquisition, consolidation, and retention of hippocampal- and amygdala-dependent learning. A common functional A-->G single nucleotide polymorphism (BDNFval66met) in the prodomain of the human BDNF gene is associated with abnormal intracellular trafficking and reduced activity-dependent BDNF release. We studied the effect of BDNFval66met in an aversive differential fear conditioning, and a delayed extinction paradigm in 57 healthy participants. Pictures of male faces were used as stimuli and fear learning was quantified by fear potentiated startle (FPS) and skin conductance responses (SCR). Aware BDNF met-carriers show a deficit in amygdala-dependent fear conditioning as indicated by an absence of FPS responses in the last acquisition block. This deficit was maintained in the first block of extinction. No genotype differences were found in conditioned SCR discrimination. These data provide evidence for the involvement of BDNF signaling in human amygdala-dependent learning. We suggest that the BDNF met-allele may have a protective effect for the development of affective pathologies that may be mediated via reduced synaptic plasticity induced by negative experience.
KW - Acoustic Stimulation
KW - Amygdala
KW - Analysis of Variance
KW - Avoidance Learning
KW - Brain-Derived Neurotrophic Factor
KW - Conditioning, Classical
KW - Electromyography
KW - Extinction, Psychological
KW - Fear
KW - Female
KW - Galvanic Skin Response
KW - Genotype
KW - Humans
KW - Male
KW - Methionine
KW - Photic Stimulation
KW - Polymorphism, Genetic
KW - Startle Reaction
KW - Students
KW - Universities
KW - Valine
U2 - 10.1037/a0018261
DO - 10.1037/a0018261
M3 - SCORING: Journal article
C2 - 20141276
VL - 124
SP - 9
EP - 15
JO - BEHAV NEUROSCI
JF - BEHAV NEUROSCI
SN - 0735-7044
IS - 1
ER -