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Amygdala response to anticipation of dyspnea is modulated by 5-HTTLPR genotype

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Amygdala response to anticipation of dyspnea is modulated by 5-HTTLPR genotype. / Stöckel, Cornelia; Esser, Roland W; Gamer, Matthias; Kalisch, Raffael; Büchel, Christian; von Leupoldt, Andreas.

In: PSYCHOPHYSIOLOGY, Vol. 52, No. 7, 16.07.2015, p. 973-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stöckel, C, Esser, RW, Gamer, M, Kalisch, R, Büchel, C & von Leupoldt, A 2015, 'Amygdala response to anticipation of dyspnea is modulated by 5-HTTLPR genotype', PSYCHOPHYSIOLOGY, vol. 52, no. 7, pp. 973-6. https://doi.org/10.1111/psyp.12417

APA

Stöckel, C., Esser, R. W., Gamer, M., Kalisch, R., Büchel, C., & von Leupoldt, A. (2015). Amygdala response to anticipation of dyspnea is modulated by 5-HTTLPR genotype. PSYCHOPHYSIOLOGY, 52(7), 973-6. https://doi.org/10.1111/psyp.12417

Vancouver

Stöckel C, Esser RW, Gamer M, Kalisch R, Büchel C, von Leupoldt A. Amygdala response to anticipation of dyspnea is modulated by 5-HTTLPR genotype. PSYCHOPHYSIOLOGY. 2015 Jul 16;52(7):973-6. https://doi.org/10.1111/psyp.12417

Bibtex

@article{9b4c51d1e4874e89bac2753bb0782355,
title = "Amygdala response to anticipation of dyspnea is modulated by 5-HTTLPR genotype",
abstract = "Dyspnea anticipation and perception varies largely between individuals. To investigate whether genetic factors related to negative affect such as the 5-HTTLPR polymorphism impact this variability, we investigated healthy, 5-HTTLPR stratified volunteers using resistive load induced dyspnea together with fMRI. Alternating blocks of severe and mild dyspnea ({"}perception{"}) were differentially cued ({"}anticipation{"}) and followed by intensity and unpleasantness ratings. In addition, volunteers indicated their anticipatory fear during the anticipation periods. There were no genotype-based group differences concerning dyspnea intensity and unpleasantness or brain activation during perception of severe vs. mild dyspnea. However, in risk allele carriers, higher anticipatory fear was paralleled by stronger amygdala activation during anticipation of severe vs. mild dyspnea. These results suggest a role of the 5-HTTLPR genotype in fearful dyspnea anticipation.",
author = "Cornelia St{\"o}ckel and Esser, {Roland W} and Matthias Gamer and Raffael Kalisch and Christian B{\"u}chel and {von Leupoldt}, Andreas",
note = "{\textcopyright} 2015 Society for Psychophysiological Research.",
year = "2015",
month = jul,
day = "16",
doi = "10.1111/psyp.12417",
language = "English",
volume = "52",
pages = "973--6",
journal = "PSYCHOPHYSIOLOGY",
issn = "0048-5772",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Amygdala response to anticipation of dyspnea is modulated by 5-HTTLPR genotype

AU - Stöckel, Cornelia

AU - Esser, Roland W

AU - Gamer, Matthias

AU - Kalisch, Raffael

AU - Büchel, Christian

AU - von Leupoldt, Andreas

N1 - © 2015 Society for Psychophysiological Research.

PY - 2015/7/16

Y1 - 2015/7/16

N2 - Dyspnea anticipation and perception varies largely between individuals. To investigate whether genetic factors related to negative affect such as the 5-HTTLPR polymorphism impact this variability, we investigated healthy, 5-HTTLPR stratified volunteers using resistive load induced dyspnea together with fMRI. Alternating blocks of severe and mild dyspnea ("perception") were differentially cued ("anticipation") and followed by intensity and unpleasantness ratings. In addition, volunteers indicated their anticipatory fear during the anticipation periods. There were no genotype-based group differences concerning dyspnea intensity and unpleasantness or brain activation during perception of severe vs. mild dyspnea. However, in risk allele carriers, higher anticipatory fear was paralleled by stronger amygdala activation during anticipation of severe vs. mild dyspnea. These results suggest a role of the 5-HTTLPR genotype in fearful dyspnea anticipation.

AB - Dyspnea anticipation and perception varies largely between individuals. To investigate whether genetic factors related to negative affect such as the 5-HTTLPR polymorphism impact this variability, we investigated healthy, 5-HTTLPR stratified volunteers using resistive load induced dyspnea together with fMRI. Alternating blocks of severe and mild dyspnea ("perception") were differentially cued ("anticipation") and followed by intensity and unpleasantness ratings. In addition, volunteers indicated their anticipatory fear during the anticipation periods. There were no genotype-based group differences concerning dyspnea intensity and unpleasantness or brain activation during perception of severe vs. mild dyspnea. However, in risk allele carriers, higher anticipatory fear was paralleled by stronger amygdala activation during anticipation of severe vs. mild dyspnea. These results suggest a role of the 5-HTTLPR genotype in fearful dyspnea anticipation.

U2 - 10.1111/psyp.12417

DO - 10.1111/psyp.12417

M3 - SCORING: Journal article

C2 - 25684362

VL - 52

SP - 973

EP - 976

JO - PSYCHOPHYSIOLOGY

JF - PSYCHOPHYSIOLOGY

SN - 0048-5772

IS - 7

ER -