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Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome.

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Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome. / Choschzick, Matthias; Lassen, Paula; Lebeau, Annette; Marx, Andreas; Terracciano, Luigi; Heilenkötter, Uwe; Jänicke, Fritz; Bokemeyer, Carsten; Izbicki, Jakob R.; Sauter, Guido; Simon, Ronald.

In: MODERN PATHOL, Vol. 23, No. 4, 4, 2010, p. 603-610.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Choschzick, M, Lassen, P, Lebeau, A, Marx, A, Terracciano, L, Heilenkötter, U, Jänicke, F, Bokemeyer, C, Izbicki, JR, Sauter, G & Simon, R 2010, 'Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome.', MODERN PATHOL, vol. 23, no. 4, 4, pp. 603-610. <http://www.ncbi.nlm.nih.gov/pubmed/20139910?dopt=Citation>

APA

Choschzick, M., Lassen, P., Lebeau, A., Marx, A., Terracciano, L., Heilenkötter, U., Jänicke, F., Bokemeyer, C., Izbicki, J. R., Sauter, G., & Simon, R. (2010). Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome. MODERN PATHOL, 23(4), 603-610. [4]. http://www.ncbi.nlm.nih.gov/pubmed/20139910?dopt=Citation

Vancouver

Choschzick M, Lassen P, Lebeau A, Marx A, Terracciano L, Heilenkötter U et al. Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome. MODERN PATHOL. 2010;23(4):603-610. 4.

Bibtex

@article{6ac6415430b04427b471c451e3a57f6a,
title = "Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome.",
abstract = "Copy number gains involving the long arm of chromosome 8, including high-level amplifications at 8q21 and 8q24, have been frequently reported in breast cancer. Although the role of the MYC gene as the driver of the 8q24 amplicon is well established, the significance of the 8q21 amplicon is less clear. The breast cancer cell line SK-BR-3 contains three separate 8q21 amplicons, the distal two of which correspond to putative target genes TPD52 and WWP1. To understand the effect of proximal 8q21 amplification on breast cancer phenotype and patient prognosis, we analyzed 8q21 copy number changes using fluorescence in situ hybridization (FISH) in a tissue microarray containing more than 2000 breast cancers. Amplification at 8q21 was found in 3% of tumors, and was associated with medullary type (P",
keywords = "Adult, Humans, Aged, Female, Middle Aged, Aged, 80 and over, Treatment Outcome, Prognosis, Gene Dosage, Kaplan-Meier Estimate, Gene Amplification, In Situ Hybridization, Fluorescence, Chromosomes, Human, Pair 8 genetics, Tissue Array Analysis, Drug Resistance, Neoplasm genetics, Breast Neoplasms genetics, Genes, myc, Adult, Humans, Aged, Female, Middle Aged, Aged, 80 and over, Treatment Outcome, Prognosis, Gene Dosage, Kaplan-Meier Estimate, Gene Amplification, In Situ Hybridization, Fluorescence, Chromosomes, Human, Pair 8 genetics, Tissue Array Analysis, Drug Resistance, Neoplasm genetics, Breast Neoplasms genetics, Genes, myc",
author = "Matthias Choschzick and Paula Lassen and Annette Lebeau and Andreas Marx and Luigi Terracciano and Uwe Heilenk{\"o}tter and Fritz J{\"a}nicke and Carsten Bokemeyer and Izbicki, {Jakob R.} and Guido Sauter and Ronald Simon",
year = "2010",
language = "Deutsch",
volume = "23",
pages = "603--610",
journal = "MODERN PATHOL",
issn = "0893-3952",
publisher = "NATURE PUBLISHING GROUP",
number = "4",

}

RIS

TY - JOUR

T1 - Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome.

AU - Choschzick, Matthias

AU - Lassen, Paula

AU - Lebeau, Annette

AU - Marx, Andreas

AU - Terracciano, Luigi

AU - Heilenkötter, Uwe

AU - Jänicke, Fritz

AU - Bokemeyer, Carsten

AU - Izbicki, Jakob R.

AU - Sauter, Guido

AU - Simon, Ronald

PY - 2010

Y1 - 2010

N2 - Copy number gains involving the long arm of chromosome 8, including high-level amplifications at 8q21 and 8q24, have been frequently reported in breast cancer. Although the role of the MYC gene as the driver of the 8q24 amplicon is well established, the significance of the 8q21 amplicon is less clear. The breast cancer cell line SK-BR-3 contains three separate 8q21 amplicons, the distal two of which correspond to putative target genes TPD52 and WWP1. To understand the effect of proximal 8q21 amplification on breast cancer phenotype and patient prognosis, we analyzed 8q21 copy number changes using fluorescence in situ hybridization (FISH) in a tissue microarray containing more than 2000 breast cancers. Amplification at 8q21 was found in 3% of tumors, and was associated with medullary type (P

AB - Copy number gains involving the long arm of chromosome 8, including high-level amplifications at 8q21 and 8q24, have been frequently reported in breast cancer. Although the role of the MYC gene as the driver of the 8q24 amplicon is well established, the significance of the 8q21 amplicon is less clear. The breast cancer cell line SK-BR-3 contains three separate 8q21 amplicons, the distal two of which correspond to putative target genes TPD52 and WWP1. To understand the effect of proximal 8q21 amplification on breast cancer phenotype and patient prognosis, we analyzed 8q21 copy number changes using fluorescence in situ hybridization (FISH) in a tissue microarray containing more than 2000 breast cancers. Amplification at 8q21 was found in 3% of tumors, and was associated with medullary type (P

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Treatment Outcome

KW - Prognosis

KW - Gene Dosage

KW - Kaplan-Meier Estimate

KW - Gene Amplification

KW - In Situ Hybridization, Fluorescence

KW - Chromosomes, Human, Pair 8 genetics

KW - Tissue Array Analysis

KW - Drug Resistance, Neoplasm genetics

KW - Breast Neoplasms genetics

KW - Genes, myc

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Treatment Outcome

KW - Prognosis

KW - Gene Dosage

KW - Kaplan-Meier Estimate

KW - Gene Amplification

KW - In Situ Hybridization, Fluorescence

KW - Chromosomes, Human, Pair 8 genetics

KW - Tissue Array Analysis

KW - Drug Resistance, Neoplasm genetics

KW - Breast Neoplasms genetics

KW - Genes, myc

M3 - SCORING: Zeitschriftenaufsatz

VL - 23

SP - 603

EP - 610

JO - MODERN PATHOL

JF - MODERN PATHOL

SN - 0893-3952

IS - 4

M1 - 4

ER -