Ambulatory (24 h) blood pressure and arterial stiffness measurement in Marfan syndrome patients: a case control feasibility and pilot study
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Ambulatory (24 h) blood pressure and arterial stiffness measurement in Marfan syndrome patients: a case control feasibility and pilot study. / Hillebrand, Matthias; Nouri, Ghazaleh; Hametner, Bernhard; Parragh, Stephanie; Köster, Jelena; Mortensen, Kai; Schwarz, Achim; von Kodolitsch, Yskert; Wassertheurer, Siegfried.
In: BMC CARDIOVASC DISOR, Vol. 16, 06.05.2016, p. 81.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Ambulatory (24 h) blood pressure and arterial stiffness measurement in Marfan syndrome patients: a case control feasibility and pilot study
AU - Hillebrand, Matthias
AU - Nouri, Ghazaleh
AU - Hametner, Bernhard
AU - Parragh, Stephanie
AU - Köster, Jelena
AU - Mortensen, Kai
AU - Schwarz, Achim
AU - von Kodolitsch, Yskert
AU - Wassertheurer, Siegfried
PY - 2016/5/6
Y1 - 2016/5/6
N2 - BACKGROUND: The aim of this work is the investigation of measures of ambulatory brachial and aortic blood pressure and indices of arterial stiffness and aortic wave reflection in Marfan patients.METHODS: A case-control study was conducted including patients with diagnosed Marfan syndrome following Ghent2 nosology and healthy controls matched for sex, age and daytime brachial systolic blood pressure. For each subject a 24 h ambulatory blood pressure and 24 h pulse wave analysis measurement was performed.RESULTS: All parameters showed a circadian pattern whereby pressure dipping was more pronounced in Marfan patients. During daytime only Marfan patients with aortic root surgery showed increased pulse wave velocity. In contrast, various nighttime measurements, wave reflection determinants and circadian patterns showed a significant difference.CONCLUSIONS: The findings of our study provide evidence that ambulatory measurement of arterial stiffness parameters is feasible and that these determinants are significantly different in Marfan syndrome patients compared to controls in particular at nighttime. Further investigation is therefore indicated.
AB - BACKGROUND: The aim of this work is the investigation of measures of ambulatory brachial and aortic blood pressure and indices of arterial stiffness and aortic wave reflection in Marfan patients.METHODS: A case-control study was conducted including patients with diagnosed Marfan syndrome following Ghent2 nosology and healthy controls matched for sex, age and daytime brachial systolic blood pressure. For each subject a 24 h ambulatory blood pressure and 24 h pulse wave analysis measurement was performed.RESULTS: All parameters showed a circadian pattern whereby pressure dipping was more pronounced in Marfan patients. During daytime only Marfan patients with aortic root surgery showed increased pulse wave velocity. In contrast, various nighttime measurements, wave reflection determinants and circadian patterns showed a significant difference.CONCLUSIONS: The findings of our study provide evidence that ambulatory measurement of arterial stiffness parameters is feasible and that these determinants are significantly different in Marfan syndrome patients compared to controls in particular at nighttime. Further investigation is therefore indicated.
KW - Adult
KW - Blood Pressure
KW - Blood Pressure Monitoring, Ambulatory
KW - Case-Control Studies
KW - Circadian Rhythm
KW - Feasibility Studies
KW - Female
KW - Humans
KW - Male
KW - Marfan Syndrome/diagnosis
KW - Middle Aged
KW - Pilot Projects
KW - Predictive Value of Tests
KW - Pulse Wave Analysis
KW - Time Factors
KW - Vascular Stiffness
U2 - 10.1186/s12872-016-0263-x
DO - 10.1186/s12872-016-0263-x
M3 - SCORING: Journal article
C2 - 27151044
VL - 16
SP - 81
JO - BMC CARDIOVASC DISOR
JF - BMC CARDIOVASC DISOR
SN - 1471-2261
ER -
