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Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment

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Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment. / Louwersheimer, Eva; Wolfsgruber, Steffen; Espinosa, Ana; Lacour, André; Heilmann-Heimbach, Stefanie; Alegret, Montserrat; Hernández, Isabel; Rosende-Roca, Maitée; Tárraga, Lluís; Boada, Mercè; Kornhuber, Johannes; Peters, Oliver; Frölich, Lutz; Hüll, Michael; Rüther, Eckart; Wiltfang, Jens; Scherer, Martin; Riedel-Heller, Steffi; Jessen, Frank; Nöthen, Markus M; Maier, Wolfgang; Koene, Ted; Scheltens, Philip; Holstege, Henne; Wagner, Michael; Ruiz, Agustín; van der Flier, Wiesje M; Becker, Tim; Ramirez, Alfredo.

In: ALZHEIMERS DEMENT, Vol. 12, No. 8, 08.2016, p. 872-81.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Louwersheimer, E, Wolfsgruber, S, Espinosa, A, Lacour, A, Heilmann-Heimbach, S, Alegret, M, Hernández, I, Rosende-Roca, M, Tárraga, L, Boada, M, Kornhuber, J, Peters, O, Frölich, L, Hüll, M, Rüther, E, Wiltfang, J, Scherer, M, Riedel-Heller, S, Jessen, F, Nöthen, MM, Maier, W, Koene, T, Scheltens, P, Holstege, H, Wagner, M, Ruiz, A, van der Flier, WM, Becker, T & Ramirez, A 2016, 'Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment', ALZHEIMERS DEMENT, vol. 12, no. 8, pp. 872-81. https://doi.org/10.1016/j.jalz.2016.01.006

APA

Louwersheimer, E., Wolfsgruber, S., Espinosa, A., Lacour, A., Heilmann-Heimbach, S., Alegret, M., Hernández, I., Rosende-Roca, M., Tárraga, L., Boada, M., Kornhuber, J., Peters, O., Frölich, L., Hüll, M., Rüther, E., Wiltfang, J., Scherer, M., Riedel-Heller, S., Jessen, F., ... Ramirez, A. (2016). Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment. ALZHEIMERS DEMENT, 12(8), 872-81. https://doi.org/10.1016/j.jalz.2016.01.006

Vancouver

Louwersheimer E, Wolfsgruber S, Espinosa A, Lacour A, Heilmann-Heimbach S, Alegret M et al. Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment. ALZHEIMERS DEMENT. 2016 Aug;12(8):872-81. https://doi.org/10.1016/j.jalz.2016.01.006

Bibtex

@article{e1a3e534d8ef40008cae98930b350b01,
title = "Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment",
abstract = "INTRODUCTION: We evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI).METHODS: We selected 1730 MCI patients from four independent data sets. Weighted polygenic risk scores (PGS) were constructed of 18 non-apolipoprotein E (APOE) AD risk variants. In addition, we determined APOE genotype. AD endophenotypes were cognitive decline over time and cerebrospinal fluid (CSF) biomarkers (aβ, tau, ptau).RESULTS: PGS was modestly associated with cognitive decline over time, as measured by mini-mental state examination (MMSE) (β ± SE:-0.24 ± 0.10; P = .012), and with CSF levels of tau and ptau (tau: 1.38 ± 0.36, P = 1.21 × 10(-4); ptau: 1.40 ± 0.36, P = 1.02 × 10(-4)).DISCUSSION: In MCI, we observed a joint effect of AD susceptibility loci on nonamyloid endophenotypes, suggesting a link of these genetic loci with neuronal degeneration in general rather than with Alzheimer-related amyloid deposition.",
keywords = "Journal Article",
author = "Eva Louwersheimer and Steffen Wolfsgruber and Ana Espinosa and Andr{\'e} Lacour and Stefanie Heilmann-Heimbach and Montserrat Alegret and Isabel Hern{\'a}ndez and Mait{\'e}e Rosende-Roca and Llu{\'i}s T{\'a}rraga and Merc{\`e} Boada and Johannes Kornhuber and Oliver Peters and Lutz Fr{\"o}lich and Michael H{\"u}ll and Eckart R{\"u}ther and Jens Wiltfang and Martin Scherer and Steffi Riedel-Heller and Frank Jessen and N{\"o}then, {Markus M} and Wolfgang Maier and Ted Koene and Philip Scheltens and Henne Holstege and Michael Wagner and Agust{\'i}n Ruiz and {van der Flier}, {Wiesje M} and Tim Becker and Alfredo Ramirez",
note = "Copyright {\textcopyright} 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.",
year = "2016",
month = aug,
doi = "10.1016/j.jalz.2016.01.006",
language = "English",
volume = "12",
pages = "872--81",
journal = "ALZHEIMERS DEMENT",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment

AU - Louwersheimer, Eva

AU - Wolfsgruber, Steffen

AU - Espinosa, Ana

AU - Lacour, André

AU - Heilmann-Heimbach, Stefanie

AU - Alegret, Montserrat

AU - Hernández, Isabel

AU - Rosende-Roca, Maitée

AU - Tárraga, Lluís

AU - Boada, Mercè

AU - Kornhuber, Johannes

AU - Peters, Oliver

AU - Frölich, Lutz

AU - Hüll, Michael

AU - Rüther, Eckart

AU - Wiltfang, Jens

AU - Scherer, Martin

AU - Riedel-Heller, Steffi

AU - Jessen, Frank

AU - Nöthen, Markus M

AU - Maier, Wolfgang

AU - Koene, Ted

AU - Scheltens, Philip

AU - Holstege, Henne

AU - Wagner, Michael

AU - Ruiz, Agustín

AU - van der Flier, Wiesje M

AU - Becker, Tim

AU - Ramirez, Alfredo

N1 - Copyright © 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

PY - 2016/8

Y1 - 2016/8

N2 - INTRODUCTION: We evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI).METHODS: We selected 1730 MCI patients from four independent data sets. Weighted polygenic risk scores (PGS) were constructed of 18 non-apolipoprotein E (APOE) AD risk variants. In addition, we determined APOE genotype. AD endophenotypes were cognitive decline over time and cerebrospinal fluid (CSF) biomarkers (aβ, tau, ptau).RESULTS: PGS was modestly associated with cognitive decline over time, as measured by mini-mental state examination (MMSE) (β ± SE:-0.24 ± 0.10; P = .012), and with CSF levels of tau and ptau (tau: 1.38 ± 0.36, P = 1.21 × 10(-4); ptau: 1.40 ± 0.36, P = 1.02 × 10(-4)).DISCUSSION: In MCI, we observed a joint effect of AD susceptibility loci on nonamyloid endophenotypes, suggesting a link of these genetic loci with neuronal degeneration in general rather than with Alzheimer-related amyloid deposition.

AB - INTRODUCTION: We evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI).METHODS: We selected 1730 MCI patients from four independent data sets. Weighted polygenic risk scores (PGS) were constructed of 18 non-apolipoprotein E (APOE) AD risk variants. In addition, we determined APOE genotype. AD endophenotypes were cognitive decline over time and cerebrospinal fluid (CSF) biomarkers (aβ, tau, ptau).RESULTS: PGS was modestly associated with cognitive decline over time, as measured by mini-mental state examination (MMSE) (β ± SE:-0.24 ± 0.10; P = .012), and with CSF levels of tau and ptau (tau: 1.38 ± 0.36, P = 1.21 × 10(-4); ptau: 1.40 ± 0.36, P = 1.02 × 10(-4)).DISCUSSION: In MCI, we observed a joint effect of AD susceptibility loci on nonamyloid endophenotypes, suggesting a link of these genetic loci with neuronal degeneration in general rather than with Alzheimer-related amyloid deposition.

KW - Journal Article

U2 - 10.1016/j.jalz.2016.01.006

DO - 10.1016/j.jalz.2016.01.006

M3 - SCORING: Journal article

C2 - 26921674

VL - 12

SP - 872

EP - 881

JO - ALZHEIMERS DEMENT

JF - ALZHEIMERS DEMENT

SN - 1552-5260

IS - 8

ER -