Alternative Splicing of FOXP3-Virtue and Vice

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Alternative Splicing of FOXP3-Virtue and Vice. / Mailer, Reiner K W.

In: FRONT IMMUNOL, Vol. 9, 2018, p. 530.

Research output: SCORING: Contribution to journalSCORING: Review articleResearch

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@article{3da2b56619b94f4aa86b4cd975800962,
title = "Alternative Splicing of FOXP3-Virtue and Vice",
abstract = "FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed.",
keywords = "Journal Article, Review",
author = "Mailer, {Reiner K W}",
year = "2018",
doi = "10.3389/fimmu.2018.00530",
language = "English",
volume = "9",
pages = "530",
journal = "FRONT IMMUNOL",
issn = "1664-3224",
publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Alternative Splicing of FOXP3-Virtue and Vice

AU - Mailer, Reiner K W

PY - 2018

Y1 - 2018

N2 - FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed.

AB - FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed.

KW - Journal Article

KW - Review

U2 - 10.3389/fimmu.2018.00530

DO - 10.3389/fimmu.2018.00530

M3 - SCORING: Review article

C2 - 29593749

VL - 9

SP - 530

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

ER -