Alternative Splicing of FOXP3-Virtue and Vice
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Alternative Splicing of FOXP3-Virtue and Vice. / Mailer, Reiner K W.
In: FRONT IMMUNOL, Vol. 9, 2018, p. 530.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Alternative Splicing of FOXP3-Virtue and Vice
AU - Mailer, Reiner K W
PY - 2018
Y1 - 2018
N2 - FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed.
AB - FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed.
KW - Journal Article
KW - Review
U2 - 10.3389/fimmu.2018.00530
DO - 10.3389/fimmu.2018.00530
M3 - SCORING: Review article
C2 - 29593749
VL - 9
SP - 530
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
ER -